DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and abcb11b

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:XP_003199513.2 Gene:abcb11b / 571189 ZFINID:ZDB-GENE-050517-14 Length:1348 Species:Danio rerio


Alignment Length:1360 Identity:535/1360 - (39%)
Similarity:788/1360 - (57%) Gaps:110/1360 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SSEGKSQEEAPMAEGL----------EPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPA 64
            |.|..|.:...||.|.          |....:.|.:||||::..||..:.||.:.........|.
Zfish    23 SDEETSGDYMTMASGKDNKSKKSKKEESAIRVGFFQLFRFASCREIWMMVFGSLCAIAHGSAQPL 87

  Fly    65 VVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTL--TNASREEN------------------ 109
            :::::...|...:|..::....|:.....:   ..|:  .|.::|||                  
Zfish    88 MLLVFGMLTDTFIDYDIELNELSDPQKACV---NNTIQWRNLTQEENLALNMTRSCGLLDIEYEM 149

  Fly   110 -NEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLAS 173
             |.|.|...|..|:         ||.|...:.::...|.||:..:|...|..|:|.:|||.|..|
Zfish   150 TNFAYYYVGIGAGV---------FILGYLQISLWITAAARQIQIIRKMYFRKVMRMEIGWFDCTS 205

  Fly   174 KQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYV 238
            .......|.||:.||.|.|:::||.|:.....|:....:.|:.||||||.:.|..||:.:....:
Zfish   206 VGELNTRMSDDINKINDAIADQVGIFIQRFTTFVCGFLMGFARGWKLTLVIISVSPLIGIGAGLM 270

  Fly   239 AKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQW---KGAF 300
            |.|..|||..|.::||.||.:|:|:|||:|||.:|||||.||.||:..|:   .|.||   ||..
Zfish   271 ALFVAKLTGMELQAYAKAGAVADEVLSSVRTVAAFGGEKKEVDRYDRNLI---SAQQWGIRKGLI 332

  Fly   301 SGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLE 365
            .|.....:..:::|..|.|||||.:|::|     .:||:|..|:..|||:::.|.|:.:.:|.||
Zfish   333 MGFFTGYMWFIIFLCYALAFWYGSSLVVD-----TQEYSPGTLLQVFFGVLIAALNLGQASPCLE 392

  Fly   366 SFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRI 430
            :||..||.||.:|:.||...:||.||..|..|: .::||:||.::.|.|||||||.:...||:::
Zfish   393 AFAAGRGAATIIFETIDREPEIDCLSEAGYKLD-KVKGDLEFHNITFHYPSRPEVKILDQLNLQV 456

  Fly   431 RAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLG 495
            ::|:|.|.||.||.||||.:||:||||||..|.:.||..|||..|||||||.|.:|.||||||..
Zfish   457 KSGETTAFVGPSGAGKSTAIQLIQRFYDPKEGMLTLDGHDIRGLNIQWLRSLIGIVEQEPVLFAT 521

  Fly   496 TIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQ 560
            |||:||.||:||.:..:|..||.:|.|:.||.:||:.:.:::||.|.|:||||||||||||||::
Zfish   522 TIAENIRYGRPGVSNDDIITAAKEANAYNFIMDLPQKFETLVGEGGGQMSGGQKQRIAIARALVR 586

  Fly   561 NPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSH 625
            ||:|||||.||||||.:||..||:|||....|||||.::||||.|:.||.||....|:.:|.|.|
Zfish   587 NPRILLLDMATSALDNESEAVVQEALDKVRMGRTTISIAHRLSTIKNADVIVGFEHGRAVERGKH 651

  Fly   626 DDLMALEGAYYNMV---RAGD--INMPDEVEKEDS---IEDTKQKSL---ALFEKSFETSPLNFE 679
            |:|:..:|.|:.:|   ..||  :|...:.|.|::   ..|.:::||   ..:..|...|.....
Zfish   652 DELLERKGVYFTLVTLQSQGDKALNQKAQQEMEEAECCDSDAERRSLNRAGSYRASLRASIHQRS 716

  Fly   680 KGQ-KNSV--------------QFEEPII------KALIKDTNAQSAEAPPEKPNFFRTFSRILQ 723
            :.| .|:|              .:.|..:      |:.:.:..|:..|..|        .:|||:
Zfish   717 RSQLSNAVPESSVAIAGELGPRSYSETTVPQEFMGKSGVPEDTAEEVEPAP--------VARILK 773

  Fly   724 LAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGL 788
            ....||.|:..|:|.|...|.:.|.::::|.:..|..:..||.:..|.   ::..|| ...:.||
Zfish   774 YNAPEWPYMFFGSIGAAVNGGVNPVYSLLFSQILATFSMPDPVEQRRE---INGICL-FFVVVGL 834

  Fly   789 VCF----LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAI 849
            |.|    ||.|.|:.:|..||.|:|.:.|.||:.||:|||||..||.|||:.||:.:|..:|||.
Zfish   835 VSFFTQMLQGYAFSKSGELLTRRLRRLGFQAMLGQEIGWFDDRKNSPGALTTRLATDASQVQGAT 899

  Fly   850 GYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEAC 914
            |..:..::.:|:|...:|.::.|::|||.|:.|...|.:..|...:|||::....::|:.:|.|.
Zfish   900 GSQIGMIVNSLTNIGVAVIISFYFSWKLTLVILCFLPFLALSGGFQAKMLTGFAKQDKEAMETAG 964

  Fly   915 RIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCY 979
            :|:.|::.||||:|||.:|.:.:..:..:::.......:|....|......|...|.|.:.:..:
Zfish   965 QISGEALNNIRTIAGLGKERNFVEMFETQLEAPYQAALKKANVYGACYGFAQCVVFMANSASYRF 1029

  Fly   980 GGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGT 1044
            ||.||....|.|..:.:|...::.....|.::.::||.::.|.|:..|.||:|||.|||     :
Zfish  1030 GGYLVYHEGLHFSFVFRVISAIVTSGTALGRASSYTPDYAKAKISAARFFQLLDRIPKI-----S 1089

  Fly  1045 IKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQ 1108
            :.:...::.:.|:| :.:...:|.||:|||.::||||::.|..|||:|.||.|||||||.||||:
Zfish  1090 VYSKDGQKWDNFKGDIEFIDCKFTYPSRPDIQVLNGLNVSVKPGQTLAFVGSSGCGKSTSVQLLE 1154

  Fly  1109 RYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAA 1173
            |:|||:.|.:.||..: ...:.:..:|:|:|||||||.||:.||||||.||||:|.:||.::|:|
Zfish  1155 RFYDPNSGRVLIDGRE-SSQINVAYLRSKIGIVSQEPILFDCSIAENIRYGDNQRELSMNDVISA 1218

  Fly  1174 AKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQL 1238
            ||.|..|.|::|||..|||.:|::|:|||.|||||||||||::|:||||||||||||||.:||:.
Zfish  1219 AKKAQLHDFVMSLPEKYDTNVGSQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKT 1283

  Fly  1239 VQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKT 1298
            ||:|||.|..|||||||||||||:||:|:|.|:..|.|:|:|.|..|:...|.|.||..|
Zfish  1284 VQEALDKAREGRTCIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHDYLMGLKGAYYKLVTT 1343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 515/1269 (41%)
ABC_membrane 108..354 CDD:279056 93/267 (35%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 131/239 (55%)
ABC_membrane 736..1006 CDD:279056 85/273 (31%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 140/240 (58%)
abcb11bXP_003199513.2 ABC_membrane 76..382 CDD:279056 100/325 (31%)
PTZ00265 157..1339 CDD:240339 504/1217 (41%)
ABC_MTABC3_MDL1_MDL2 432..668 CDD:213216 131/235 (56%)
ABC_membrane 787..1053 CDD:279056 85/269 (32%)
ABC_MTABC3_MDL1_MDL2 1105..1344 CDD:213216 140/240 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 181 1.000 Domainoid score I3416
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.860

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