Protein Alignment Mdr65 and Abcb10

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_062425.1
• Gene: Abcb10 / 56199
• MGIID: 1860508
• Length: 715
• Species: Mus musculus
• Alignment Length: 607
• Identity: 210/607 - (34%)
• Similarity: 326/607 - (53%)
• Gaps: 59/607 - (9%)

  Fly   720 RILQLAKQEWCYLILGTISAVAVGFLYPAFAV----------IFGEFYAALAEKDPEDALRRTAV 774
            ::|.|.:.|     .|.:|| |||||..:..:          |....|...:|...:...|..||
Mouse   124 KLLGLVRPE-----RGRLSA-AVGFLAVSSVITMSAPFFLGRIIDVIYTNPSEGYGDSLTRLCAV 182

  Fly   775 LSWACLGLAFLTGLVC-FLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARL 838
            |:  |:   ||.|... .::.||...:|..:..|:|...|::::.|||.:||  ....|.|..||
Mouse   183 LT--CV---FLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRL 240

  Fly   839 SGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAV 903
            |.:...:..::...||..::|.:.....|.:..:.:..||...|:..|.|....::..:.:....
Mouse   241 SSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLS 305

  Fly   904 VREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQAS 968
            ...:..:.||.::|.|.|.||||:....:|...:.:||..:.::..|.:::         .:..:
Mouse   306 KATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKE---------ALARA 361

  Fly   969 AFFAYA--------VALCY-GGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALI- 1023
            .||..|        :::.| ||:|:....:   .:.::|..|:| :..:..|:....:|.:.|:
Mouse   362 GFFGAAGLSGNLIVLSVLYKGGLLMGSAHM---TVGELSSFLMY-AFWVGLSIGGLSSFYSELMK 422

  Fly  1024 ---AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEV 1084
               ||.||:::|:|:|::....|.:.:.     ..|:| :.:|.:.|.||.||:..:.....|.:
Mouse   423 GLGAGGRLWELLERQPRLPFNEGMVLDE-----KTFQGALEFRNVHFTYPARPEVSVFQDFSLSI 482

  Fly  1085 LKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFE 1149
            ..|...||||.||.||||.|.||.|.|||:.||:.:|..||: .|....:|:|:|.|||||.||.
Mouse   483 PSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIR-QLNPVWLRSKIGTVSQEPVLFS 546

  Fly  1150 RSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
            .|:||||||| ||..||:..::..||:.|||..||.|.|.|:||.:|.:|..|||||||||||||
Mouse   547 CSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIAR 611

  Fly  1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVE 1278
            ||::|||||||||||||||.::|.|||:|||....|||.::|||||||::||:.:.|:.:|::.|
Mouse   612 ALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICE 676

  Fly  1279 QGNHMQ-LISQGGIYAKLHKTQ 1299
            .|.|.: |:...|:|.||...|
Mouse   677 HGTHEELLLKPNGLYRKLMNKQ 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	210/607 (35%)
		ABC_membrane	108..354	CDD:279056
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216
		ABC_membrane	736..1006	CDD:279056	66/289 (23%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	126/241 (52%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	207/601 (34%)
		ABC_membrane	142..403	CDD:279056	61/280 (22%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	126/240 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910