DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB1

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001335874.1	Gene:	ABCB1 / 5243	HGNCID:	40	Length:	1350	Species:	Homo sapiens

Alignment Length:	1312	Identity:	550/1312 - (41%)
Similarity:	794/1312 - (60%)	Gaps:	79/1312 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFT 73
            :.||...:|:.|         .::...:||:|.:.:..::..|.:...|....||.:::::.|.|
Human    91 NKSEKDKKEKKP---------TVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMT 146

  Fly    74 SMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEA-----LYDDSISYGILLTIASVVMFI 133
            .:       |..:.|:..|.     ..:||  |.:.|:.     |.:|...|....:.....:.:
Human   147 DI-------FANAGNLEDLM-----SNITN--RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLV 197

  Fly   134 SGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGH 198
            :....|..:.:.|.||:.::|.:.|.:::||:|||.|:.........:.|||.||.:||.:|:|.
Human   198 AAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGM 262

  Fly   199 FVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEI 263
            |...:..|.....:.|:.||||||.:.:..|::.|.....||.....|.:|..:||.||.:|||:
Human   263 FFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEV 327

  Fly   264 LSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLII 328
            |::||||::|||:|.|::||...|..|::....|...:.:|......::|.|.|.|||||..|::
Human   328 LAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVL 392

  Fly   329 DDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTD 393
                  :.||:...::..||.:::||.::.:.:|.:|:||.|||.|..:||:||....||..|..
Human   393 ------SGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKS 451

  Fly   394 GKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYD 458
            |...: .::|::||::|.|.||||.||.:.:|||:::::||||||||:|||||||.|||:||.||
Human   452 GHKPD-NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 515

  Fly   459 PVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAH 523
            |..|.|.:|..|||..|:::||..|.||.||||||..|||:||.||:...|..|||.|..:|.|:
Human   516 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY 580

  Fly   524 EFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDL 588
            :||..||..:.:::||||:||||||||||||||||::|||||||||||||||.:||..||.|||.
Human   581 DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDK 645

  Fly   589 ASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAGDINMPDEV 650
            |.|||||||::||||.:|.||.|....||.::|:|:||:||..:|.|:.:|   .||     :||
Human   646 ARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG-----NEV 705

  Fly   651 EKEDSIEDTKQKSLALFEKSFET-SPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEA-----PP 709
            |.|::.:::|.:..||...|.:: |.|..::..:.||:..:      .:|....:.||     ||
Human   706 ELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQ------AQDRKLSTKEALDESIPP 764

  Fly   710 EKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAE-KDPEDALRRTA 773
            .      :|.||::|...||.|.::|...|:..|.|.||||:||.:....... .|||...:.:.
Human   765 V------SFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSN 823

  Fly   774 VLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARL 838
            :.|...|.|..::.:..|||.:.|..||..||.|:|.|.|.:|:.|:|.||||..|:.|||:.||
Human   824 LFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRL 888

  Fly   839 SGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAV 903
            :.:|..::||||..|:.:.|.::|..:.:.::..|.|:|.||.||..|||..:.::|.||:|...
Human   889 ANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA 953

  Fly   904 VREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWR---GVLNSTM 965
            :::|:.:|.:.:||||:|.|.|||..|.:|......|.:.:|   |..|..||..   |:..|..
Human   954 LKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQ---VPYRNSLRKAHIFGITFSFT 1015

  Fly   966 QASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQ 1030
            ||..:|:||....:|..||:...:.|:|::.|...:::|:|.:.|..:|.|.::.|.|:...:..
Human  1016 QAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIM 1080

  Fly  1031 ILDRKPKIQ--SPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVAL 1092
            |:::.|.|.  |..|.:.|||       || |.:..:.|.||||||..:|.||.|||.||||:||
Human  1081 IIEKTPLIDSYSTEGLMPNTL-------EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLAL 1138

  Fly  1093 VGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIA 1157
            ||.|||||||.||||:|:|||..|.:.:|..:|:. |.:..:|..||||||||.||:.|||||||
Human  1139 VGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKR-LNVQWLRAHLGIVSQEPILFDCSIAENIA 1202

  Fly  1158 YGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKIL 1222
            ||||.|.||..||:.|||.||.|:||.||||.|.|::|.:||||||||||||||||||||.|.||
Human  1203 YGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1267

  Fly  1223 LLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS 1287
            ||||||||||.:||::||:|||.|..|||||||||||||:||||:|.|.|||:|.|.|.|.||::
Human  1268 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1332

  Fly  1288 QGGIYAKLHKTQ 1299
            |.|||..:...|
Human  1333 QKGIYFSMVSVQ 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	535/1230 (43%)
		ABC_membrane	108..354	CDD:279056	76/250 (30%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	141/239 (59%)
		ABC_membrane	736..1006	CDD:279056	95/273 (35%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	156/239 (65%)
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	540/1262 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3116
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760