Protein Alignment Mdr65 and ABCB7

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_728642.2
• Gene: ABCB7 / 38193
• FlyBaseID: FBgn0035244
• Length: 743
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 181/597 - (30%)
• Similarity: 288/597 - (48%)
• Gaps: 64/597 - (10%)

  Fly    94 LFGGG-KTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVD----------VFNMVAL 147
            ||.|. .|:|..:.:...:|          :|:.|:.:|...||....          ||..||.
  Fly   178 LFKGAVDTMTTLNMDTAPDA----------VLSAATALMLGYGIARASAAGFNELRNAVFAKVAH 232

  Fly   148 RQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVA- 211
            ..:.::...:|..:...|:.:|  .:||  |.::...:::...||:..:...|:.:|..|..:|
  Fly   233 HSIRKIASNVFLHLHNLDLAFH--LNKQ--TGALSKTIDRGSRGINFVLSAMVFNIVPTIFELAL 293

  Fly   212 ISFSYGWKLTLA--------VSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIR 268
            :|...|.|..||        |..|....:.:..:..:|:..:...|.|    |||.|.:.|.:..
  Fly   294 VSSILGVKCGLAFAGVSMGCVGIYAAYTLSVTQWRTQFRVFMNQAENE----AGNKAVDSLINYE 354

  Fly   269 TVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGL----SDAVLKSMLYL---SCAGAFWYGVNL 326
            ||..|..||.|...|...|.....||....:...|    .:|:..|.|.|   ..|.....| |:
  Fly   355 TVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIFSSALSLIMVLAAKEIAQG-NM 418

  Fly   327 IIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLS 391
            .:.|..:.|.......:.:.|.|.:.   ...|.| .|:..|        :|.::::.|.|...:
  Fly   419 TVGDLVMVNALLFQLSIPLGFLGSVY---REVRQA-LLDMRA--------MFTLMNVDSSIQTAA 471

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRY-PSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQR 455
            ....|........:||::|.|.| |.:|   :.|.|:..|.||:.||:||.||.|||:.|:||.|
  Fly   472 NAQPLFVDTTNSSIEFRNVSFEYEPGKP---IFRDLSFTIPAGKNVAIVGGSGSGKSSMVRLLFR 533

  Fly   456 FYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQA 520
            |::|..|.||:...||...:::.||..||||.|:.|||..||..||.||....:..|::.||..|
  Fly   534 FFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNLSKSHAEVQNAARMA 598

  Fly   521 GAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQA 585
            ..|:.|.:.|..|.:.:||||.:||||:|||:|||||:::|..||:.|||||:||..:|..:.||
  Fly   599 DLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEATSSLDSITEHNILQA 663

  Fly   586 LDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNM--VRAGDINMPD 648
            |..|:.|||:|.::||||.::.||:|:.:.:|:|.|.|:|.:|:...|.|..:  .:....:...
  Fly   664 LTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYARLWETQTQQFDPSR 728

  Fly   649 EVEKEDSIEDTK 660
            |:.:|.:.:.|:
  Fly   729 EINEEVAAKKTR 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	181/597 (30%)
		ABC_membrane	108..354	CDD:279056	59/271 (22%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	106/239 (44%)
		ABC_membrane	736..1006	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	62/277 (22%)
		ATM1	222..717	CDD:227590	167/518 (32%)
		P-loop_NTPase	485..720	CDD:304359	106/237 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I2340
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010