DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and Mdr49

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster


Alignment Length:1319 Identity:594/1319 - (45%)
Similarity:862/1319 - (65%) Gaps:55/1319 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 KSQEEAPMA------EG--LEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYS 70
            |.:...|.|      ||  ::.|...::..|||:||..|...|....::....:..:|..:|||.
  Fly     4 KEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYG 68

  Fly    71 EFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISG 135
            ||||:||||.:..||||...|||:||||:.|||||:||||:|:.||:.::||...:.||.||:..
  Fly    69 EFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLI 133

  Fly   136 IFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFV 200
            ..::|:.|.:||.|:.|:|.....:::||||.|:|.:|..||...|.:|::|:::||.||:...|
  Fly   134 TLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVV 198

  Fly   201 YLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILS 265
            :|::.|:|.:..:|.|||||||.|.|.:|.:|.....||:.||.|..:|.:||:.|.|:.||:.|
  Fly   199 FLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFS 263

  Fly   266 SIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
            .||||.:|.|::.|.:|:...|:||....:.||.:||:.:|:...::||..|.|.||||.||:|:
  Fly   264 GIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDE 328

  Fly   331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGK 395
            |::.::.||||:|:|..|.:|:||.|:...:|.:|:.|.|......||.:||..|::||:...|.
  Fly   329 RDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN 393

  Fly   396 LLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPV 460
            ... ...|.:.|:.:.||||:||:|.:.:||.:.:..|||||.||:|||||||.:||:||||||.
  Fly   394 RPE-NTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPE 457

  Fly   461 FGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEF 525
            .|||.||..|:|..|:.||||.|.|||||||||..||.:||.||:|.|||.:||.||..|..|:|
  Fly   458 AGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDF 522

  Fly   526 ITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLAS 590
            ||.||:.|.:.:||:|:|:||||||||||||||::.|::|||||||||||..|||:||.||:|||
  Fly   523 ITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELAS 587

  Fly   591 KGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVR--------------- 640
            :|.||:||:||||.|..||||||:.||.|.|:|:|::||...|.|..:|.               
  Fly   588 QGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAV 652

  Fly   641 AG-----DINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDT 700
            ||     ..|:.|| |.:|..||.::..    |...:||..:.:.|.:.|.:          :..
  Fly   653 AGRPLQKSQNLSDE-ETDDDEEDEEEDE----EPELQTSGSSRDSGFRASTR----------RKR 702

  Fly   701 NAQSAEAPPEKPNFFR-TFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKD 764
            .:|..:...:|....: :|:::::|...||.::::|.|::|..|..:|.:.:.||:|:..|::.|
  Fly   703 RSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGD 767

  Fly   765 PEDALRRTAV-LSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDEN 828
             :|.:|...: :|...:|:..:.||...||||:|..||:.:|||:|...|..::.|::.:||||.
  Fly   768 -DDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDER 831

  Fly   829 NSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVI 893
            ||||||.:||:.:..::|||.|..:..|:||::..:..:.|...::|:..||.|...|::..||.
  Fly   832 NSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVY 896

  Fly   894 LEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWR 958
            ||.:.:..:..:.|..||||.::|.|:|||||||.||..|..|:.:|.::|.||::..|:|:|:|
  Fly   897 LEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFR 961

  Fly   959 GVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALI 1023
            |::.:..||:.|.||.:::.|||:||:|.::.::|||||:|.|::||.||.|:||:.|..:.|::
  Fly   962 GLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAIL 1026

  Fly  1024 AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKG 1087
            :..||..:..|.....:|..:..||:.|.    || :.|..:.|.||||....||.||:|.:.|.
  Fly  1027 SAGRLMDLFKRTSTQPNPPQSPYNTVEKS----EGDIVYENVGFEYPTRKGTPILQGLNLTIKKS 1087

  Fly  1088 QTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSI 1152
            .||||||.||.|||||||||.|||||..|::::.... ..:..||.:|:|||:|||||.||:|:|
  Fly  1088 TTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVP-STEFPLDTLRSKLGLVSQEPVLFDRTI 1151

  Fly  1153 AENIAYGDN-RRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALV 1216
            |||||||:| |..|||.|||.|||.:|.|:||.:||.|||||:| :.:|||||||||||||||||
  Fly  1152 AENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALV 1215

  Fly  1217 RNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGN 1281
            ||||||:||||||||||:||::||||||.|.|||||:.|||||:||:|||:|||::.|.|||.|.
  Fly  1216 RNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGT 1280

  Fly  1282 HMQLISQGGIYAKLHKTQK 1300
            |.:|::...|||.|:..|:
  Fly  1281 HDELMALNKIYANLYLMQQ 1299

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 564/1232 (46%)
ABC_membrane 108..354 CDD:279056 100/245 (41%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 143/251 (57%)
ABC_membrane 736..1006 CDD:279056 103/270 (38%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 151/240 (63%)
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 295/606 (49%)
ABC_membrane 116..352 CDD:279056 94/235 (40%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 142/233 (61%)
MdlB 735..1299 CDD:224055 272/570 (48%)
ABC_membrane 739..998 CDD:279056 96/259 (37%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 151/240 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 162 1.000 Domainoid score I1247
eggNOG 1 0.900 - - E2759_KOG0055
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 156 1.000 Inparanoid score I209
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm951
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - P PTHR24221
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
1211.910

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