Protein Alignment Mdr65 and Abcb10

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001012166.1
• Gene: Abcb10 / 361439
• RGDID: 1311222
• Length: 715
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 213/609 - (34%)
• Similarity: 324/609 - (53%)
• Gaps: 63/609 - (10%)

  Fly   720 RILQLAKQEWCYLILGTISAVAVGFLYPAFAV----------IFGEFYAALAEKDPEDALRRTAV 774
            ::|.|.:.|     .|.:|| |||||..:..:          |....|....| |..|:|.|
  Rat   124 KLLGLVRPE-----RGRLSA-AVGFLAVSSVITMSAPFFLGKIIDVIYTNPTE-DFGDSLTR--- 178

  Fly   775 LSWACLGL--AFLTGLVC-FLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSA 836
               .|.||  .||.|... .::.||...:|..:..|:|...|::::.|||.:||  ....|.|..
  Rat   179 ---LCAGLTCVFLCGAAANSIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFD--KTRTGELIN 238

  Fly   837 RLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSN 901
            |||.:...:..::...||..::|::.....|.:..:.:..||...|:..|.|....::..:.:..
  Rat   239 RLSSDTALLGHSVTENLSDGLRAVAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYGRYLRK 303

  Fly   902 AVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQ 966
            .....:..:.||.::|.|.|.||||:....:|...:.:||..:.::..|.|::         .:.
  Rat   304 LSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTSRVDQLLQLARKE---------ALA 359

  Fly   967 ASAFFAYA--------VALCY-GGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAAL 1022
            .:.||..|        :::.| ||:|:....:   .:.::|..|:| :..:..|:....:|.:.|
  Rat   360 RAGFFGAAGLSGNLIVLSVLYKGGLLLGSTHM---TVGELSSFLMY-AFWVGLSIGGLSSFYSQL 420

  Fly  1023 I----AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDL 1082
            :    ||.||:::|:|:|::....|.:.:.     ..|:| :.:|.:.|.||.||:..:.....|
  Rat   421 MKGLGAGGRLWELLERQPRLPFNEGIVLDE-----KTFQGALEFRNVHFTYPARPEVSVFQDFSL 480

  Fly  1083 EVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTL 1147
            .:..|...||||.||.||||.|.||.|.|||..||:.:|..||: .|....:|:|:|.|||||.|
  Rat   481 SIPSGSVTALVGPSGSGKSTVVSLLLRLYDPSSGTVSLDGHDIR-QLNPVWLRSKIGTVSQEPVL 544

  Fly  1148 FERSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAI 1211
            |..|:||||||| ||..||:..::..||:.|||..||.|.|.|:||.:|.:|..|||||||||||
  Rat   545 FSCSVAENIAYGADNLSSVTARQVERAAEVANAAEFIRSFPQGFDTVVGEKGVLLSGGQKQRIAI 609

  Fly  1212 ARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQV 1276
            ||||::|||||||||||||||.::|.|||:|||....|||.::|||||||::||:.:.|:..|::
  Rat   610 ARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLNQGKI 674

  Fly  1277 VEQGNHMQ-LISQGGIYAKLHKTQ 1299
            .|.|.|.: |:...|:|.||...|
  Rat   675 CEHGTHEELLLKPNGLYRKLMNKQ 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	213/609 (35%)
		ABC_membrane	108..354	CDD:279056
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216
		ABC_membrane	736..1006	CDD:279056	69/291 (24%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	126/241 (52%)
Abcb10	NP_001012166.1	3a01208	10..694	CDD:273363	210/603 (35%)
		ABC_membrane	142..403	CDD:279056	64/282 (23%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	126/240 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910