DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and Abcc10

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001101671.1 Gene:Abcc10 / 316231 RGDID:1306696 Length:1494 Species:Rattus norvegicus


Alignment Length:1414 Identity:319/1414 - (22%)
Similarity:562/1414 - (39%) Gaps:375/1414 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 KLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGK 99
            :|:| :.||..|        ||..||.|..:|.....|:..|:              |.|..|  
  Rat   273 QLWR-ALYGAFG--------CCYIALGLLKMVGTMLGFSGPLL--------------LSLLVG-- 312

  Fly   100 TLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMV-------ALRQVT-RMRIK 156
                 ..||..|.|     |:|:|        ::.|:.|..|.:.|       .:|:|| :.|:.
  Rat   313 -----FLEEGQEPL-----SHGLL--------YVLGLASGSVISAVLQNQYGYEVRKVTLQARVA 359

  Fly   157 LFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGW--K 219
            :.|.:.|:.:       |...::....:|..:....||::.:|           |.||...|  .
  Rat   360 VLSILYRKTL-------KLGPSRPPTGEVLNLLGTDSERLLNF-----------AGSFHEAWGLP 406

  Fly   220 LTLAVSSYI----------------PLVILLNYYVAKFQGKLTAREQESYA---GAGNLAEEILS 265
            |.||::.|:                .|::.:|..:|.   ::.|..||...   ....|..|:||
  Rat   407 LQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIAT---RIMANNQEMLRHKDARVKLMTELLS 468

  Fly   266 SIRTVVSFGGEKSEVQRYENFLVPARKA--SQWKGAFSGLSDAVLKSMLYLSCAGAF-WYGVNLI 327
            .||.:..|        |:|..|....||  :|..|.        |:.:.||..|..: |..:   
  Rat   469 GIRVLKFF--------RWEQALGDRVKACRTQELGR--------LRVIKYLDAACVYLWAAL--- 514

  Fly   328 IDDRNVENKEYTPAILMIAFF--GIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSK-IDP 389
                        |.::.|..|  .:::|                .:..||.:|..:.|... |.|
  Rat   515 ------------PVVICIVIFITYVLLG----------------HQLTATKVFTALALVHMLILP 551

  Fly   390 LSTDGKLLNYGLRGDVEFQDVFFRY----------------PSRPEVI--VHRGL---------- 426
            |:....::|..|...|.. |...|:                |:.|..:  :|..|          
  Rat   552 LNNFPWVINGLLESKVSL-DRIQRFLDLPSYSPEAYYSPDPPTEPSTVLELHEALFSWDPTGTSQ 615

  Fly   427 -----NIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVV 486
                 :::::.|..|.:||..|||||:.:..:......:.|.|.:.||.          ....:.
  Rat   616 KTFISHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLS----------KGFGLA 670

  Fly   487 GQEPVLFLGTIAQNISYGKPGATQ---KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQ 548
            .|||.:...||..|:.:||....|   :.:||.|    .::.::.||...::.:||:|..|||||
  Rat   671 TQEPWIQCATIRDNVLFGKTFDAQLYREVLEACA----LNDDLSILPAGDQTEVGEKGVTLSGGQ 731

  Fly   549 KQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTT-IVVSHRLSAIRGADKIV 612
            :.|||:|||:.|...:.|||:..:|:|......:.....|...|.|| ::.:||...:..||.::
  Rat   732 RARIALARAVYQEKTLYLLDDPLAAVDADVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVL 796

  Fly   613 FIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLN 677
            .:..|:::..|...:::.|       |:|....:.|   ||...:..:..|:...||:.|    .
  Rat   797 LMEAGRLVRAGPPSEILPL-------VQAAPTALAD---KEQVTDSGQSPSVHNLEKTTE----E 847

  Fly   678 FEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAV 742
            .:..|..|.:..:       :::.::.|.|              |.:.:..|..:..|..:|:.:
  Rat   848 LDVAQNTSGRLVQ-------EESKSEGAVA--------------LHVYRAYWRAMGSGLATAILI 891

  Fly   743 GFLYPAFAVIFGEFYAA-----------LAEKDPEDALRRTAVLSWACLGLAFLTGLVCF----- 791
            ..|.........:::.|           .:|:.|..:..|:       :|. |...|:.|     
  Rat   892 SLLLMQATRNGADWWLAHWLSQLKAGRNSSEERPASSSPRS-------MGF-FSPRLLLFSPGNL 948

  Fly   792 --------------LQTYLFNYAGI----WLTTRMRAMTFNA----------------MVNQEVG 822
                          :..||..||.|    .|.|.:||:.|.|                ::...|.
  Rat   949 YIPLHKATSNGSSDVHFYLTVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVT 1013

  Fly   823 WFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPI 887
            ::|  :...|.:..|.|.:...:..::.:        |.|.:.:.||.:     |.||.      
  Rat  1014 FYD--STPSGRVLNRFSSDVACVDDSLPF--------LLNILLANSVGL-----LGLLA------ 1057

  Fly   888 IVGS----VILEAKMMS----NAVVREKQVIEEACRIATESITNI-----RTVAGL--RREADVI 937
            ::||    ::|....:|    ....|.:....|..|:.:.:::.:     .|:|||  .|.|...
  Rat  1058 VLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRAAGAT 1122

  Fly   938 REYTEEIQRVEVLIRQ-------KLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDII 995
            ..:.||.||:..|.::       .::|..:....|.|:...|.|     |..||...|       
  Rat  1123 YRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIA-----GIALVQHQQ------- 1175

  Fly   996 KVSETLLYGSMMLAQSLAFTPAFS----------AALIAGHRLFQILDRKPKIQSPMGTIKNTLA 1050
            .::...|.| ::|:.:|:.|...|          |.:::..||.:.....|  |.|.|....:..
  Rat  1176 GLANPGLVG-LVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDIP--QEPHGQPPQSPH 1237

  Fly  1051 KQLN-LFEG-VRYRGIQFRY-PTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYD 1112
            :::: |.:| |.::.:...| |..|:|  |:|:...|..|:.:.:||.:|.|||:...:|.|..:
  Rat  1238 QRVSWLTQGSVEFQDVVLVYRPGLPNA--LDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLE 1300

  Fly  1113 PDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENI---AYGDNRRSVSMVEIIAAA 1174
            |..|.:.:|..|.. .|.|..:|::|.::.|||.||..::.||:   ...::|.....:|....:
  Rat  1301 PSAGQVLLDGVDTS-QLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHLS 1364

  Fly  1175 KSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLV 1239
            :.|.|       ..|.|..:|.||..||.||:|.:.:||||:.:.|||.:||||:::|.:::||:
  Rat  1365 EVAMA-------IGGLDGELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLL 1422

  Fly  1240 QQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQ 1288
            ||.:....:.:|.:.|||||:|:.|:|.:.|:|.|:|||..:...|.:|
  Rat  1423 QQTICRRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQ 1471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 306/1358 (23%)
ABC_membrane 108..354 CDD:279056 57/279 (20%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 66/273 (24%)
ABC_membrane 736..1006 CDD:279056 62/341 (18%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 79/234 (34%)
Abcc10NP_001101671.1 CFTR_protein 211..1485 CDD:273530 319/1414 (23%)
ABC_membrane 290..552 CDD:294371 71/363 (20%)
ABCC_MRP_domain1 599..802 CDD:213217 57/216 (26%)
ABC_membrane 957..1190 CDD:294371 53/266 (20%)
PBP2_NikA_DppA_OppA_like <1201..>1274 CDD:294989 17/76 (22%)
ABCC_MRP_domain2 1246..1465 CDD:213211 78/228 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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