DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr65 and Abcb5

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:XP_006240775.1 Gene:Abcb5 / 314537 RGDID:1566342 Length:1255 Species:Rattus norvegicus


Alignment Length:1293 Identity:510/1293 - (39%)
Similarity:745/1293 - (57%) Gaps:69/1293 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV 77
            |..||:.|.| |.:...||   ::|||:...:|..:..|.:...|...|:|.:.::..|.:...:
  Rat    18 GSLQEQLPKA-GNQAVGPI---EIFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEISDHFI 78

  Fly    78 DRAMQFGTSSNVHALPLFGGGKTLTNASREEN----NEALYDDSISYGILLTIASVVMFISGIFS 138
            :                  |....||.::.:|    .|.|.:|.|...:..........:.|...
  Rat    79 N------------------GCLVQTNKTKYQNCSQSQEKLNEDIIMLTLYYVGIGAAALVLGYVQ 125

  Fly   139 VDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLV 203
            :..:.:.|.||.||:|.:.|.|::.|||.|.|..........|..|:.|:.|||.:|:......:
  Rat   126 ISFWVITAARQTTRIRKQFFHSILAQDISWFDGTDICELNTRMNGDISKLCDGIGDKIPLMFQNI 190

  Fly   204 VGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIR 268
            .||.|.:.||....|||:||:.|..||::..:...::....||::|.::|:.||.:|||.|||||
  Rat   191 SGFSIGLVISLIKSWKLSLAILSTSPLIMAASALCSRMVISLTSKELDAYSKAGAVAEEALSSIR 255

  Fly   269 TVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNV 333
            ||.:||.::.|:|||...|..|:.|...:...|.||...:...:..:...|||||.:||...   
  Rat   256 TVTAFGAQEKEIQRYTQNLKDAKDAGIKRAIASKLSLGAVYFFMNGAYGLAFWYGTSLIFGG--- 317

  Fly   334 ENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLN 398
             ...||...::..||.:|..:..|...||.||:|..|||.|.|:|.|||....||..||.|    
  Rat   318 -EPGYTVGTILAVFFSVIHSSYCIGSVAPHLETFTIARGAAFNIFHVIDKKPNIDNFSTAG---- 377

  Fly   399 Y---GLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPV 460
            |   .:.|::||::|.|.|||||...:.:|.|::|::|:||||||.||.||:|.||||||.|||.
  Rat   378 YKPESIEGNIEFKNVSFSYPSRPSAKILKGFNLKIKSGETVALVGPSGSGKTTTVQLLQRLYDPE 442

  Fly   461 FGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEF 525
            .|.:.:|:.|||..|::..|..|.||.||||||..||..||.:|:.|.:::|:|.||.:|.|::|
  Rat   443 EGCITVDENDIRTQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVSEEEMEQAAREANAYDF 507

  Fly   526 ITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLAS 590
            |...|:.:.:::||:|:|:||||||||||||||::|||||:|||||||||.:||..||.||:.||
  Rat   508 IMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQAALEKAS 572

  Fly   591 KGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDE-VEKED 654
            |||||:||:||||.|||||.||.:.||:|:|:|.|.:|||.:|.||::..|.||...|| :|...
  Rat   573 KGRTTLVVAHRLSTIRGADLIVTMKDGEVVEKGIHAELMAKQGLYYSLAVAQDIKKVDEQMESRT 637

  Fly   655 SIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFR-TF 718
            ........:.:|...:...||.        :.||||.:               |.:|..... :.
  Rat   638 CSAAGNASNGSLCNVNSAKSPC--------TDQFEEAV---------------PHQKTTLPEVSL 679

  Fly   719 SRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLA 783
            .:|.:|:|.||.:::|||:::...|.::|||::|||:......:|: :..|::.|.|....|.:.
  Rat   680 LKIFKLSKSEWPFVVLGTLASALNGSVHPAFSIIFGKLVTMFEDKN-KTTLKQDAELYSMMLVVL 743

  Fly   784 FLTGLVCFLQTYLF-NYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQG 847
            .:..||.:|...|| ..|...|..|:|...|.||:.|::.|:|:::||.|||:..|:.:...|:|
  Rat   744 GIVALVTYLMQGLFYGRAEEILAMRLRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVAQIRG 808

  Fly   848 AIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEE 912
            |....|..:.|.::|...|:.::..|.|::.||.|:..||:..:.:::...|:....::||.::.
  Rat   809 AATSRLGIITQDVTNMSLSILISFVYGWEMTLLILSFAPILAVTGMIQTAAMAGFANKDKQELKR 873

  Fly   913 ACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVAL 977
            |.:||||::.|||||..|.||......|.|.::.......::....|...:...|...||:|...
  Rat   874 AGKIATEAVENIRTVVSLTREKAFEHMYEETLRTQHRNALKRAHITGSCYAVSHAFVHFAHAAGF 938

  Fly   978 CYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPM 1042
            .:|..|:..|::..:.:..|...:.||:|.:.::|.:.|.:|.|......||.:|..||.|.|..
  Rat   939 RFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGAAHLFALLKNKPSIDSCS 1003

  Fly  1043 GTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLL 1107
            ...:...|.:.||    .:|.:.|.||.||:..:|..:.|.:.||:|||.||.||||||||||||
  Rat  1004 QNGEKPDACEGNL----EFREVSFFYPCRPEVPVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLL 1064

  Fly  1108 QRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIA 1172
            ||:|||.:|.:.:|..|:: :|.:..:|::..||||||.||..|||||||||||.|.|.:.||..
  Rat  1065 QRFYDPMKGQVLLDGVDVK-ELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKE 1128

  Fly  1173 AAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQ 1237
            .|.:||.||||..||..|.|::|.||..||||||||:||||||:|.||||||||||||||.:||:
  Rat  1129 VADAANIHSFIEGLPGKYSTQVGLRGMHLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEK 1193

  Fly  1238 LVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
            :||||||.|..||||:|:||||||:||||:|.|:|||::.|||.|.:|:..|..|.||
  Rat  1194 MVQQALDKARRGRTCLVVAHRLSTIQNADMIVVLQNGRIKEQGTHQELLRNGETYFKL 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 493/1215 (41%)
ABC_membrane 108..354 CDD:279056 79/249 (32%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 134/236 (57%)
ABC_membrane 736..1006 CDD:279056 77/270 (29%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 141/237 (59%)
Abcb5XP_006240775.1 PTZ00265 48..1252 CDD:240339 498/1259 (40%)
ABC_membrane 53..334 CDD:279056 85/302 (28%)
ABC_MTABC3_MDL1_MDL2 387..624 CDD:213216 134/236 (57%)
ABC_membrane 697..963 CDD:279056 75/266 (28%)
ABC_MTABC3_MDL1_MDL2 1017..1254 CDD:213216 141/236 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3071
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.730

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