DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and mdl1

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_595751.1	Gene:	mdl1 / 2541285	PomBaseID:	SPBC9B6.09c	Length:	726	Species:	Schizosaccharomyces pombe

Alignment Length:	725	Identity:	211/725 - (29%)
Similarity:	336/725 - (46%)	Gaps:	164/725 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVSTSSSEG------KSQEEAPMAEGLEPTEPIAFLKL------------------FRFSTYGE 44
            :.:|..:|.|      |:....|.:..:.|...:|||||                  .:.:|.|.
pombe    70 NSLSQKASSGSKIYPFKNSFPLPFSRSILPIRSLAFLKLCVRHNSTVPSKDEQAQDISKINTNGT 134

  Fly    45 I-------------------GWLFF--GFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSN 88
            :                   ||.||  |.::.....:|:.   |.|      :|.:.:..|:|.
pombe   135 LQTPNKKVNVFRLFTLARGQGWNFFIAGSLLLVSSGVTMS---IPY------IVGKILDAGSSG- 189

  Fly    89 VHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFIS--GIF---------SVDVF 142
                                      |.|:::  ::.|.|...:|.  |:|         .:...
pombe   190 --------------------------DSSVTH--IMGIPSGTFYIGLLGLFFLGSACNFGRIITL 226

  Fly   143 NMVALRQVTRMRIKLFSSVIRQD---IGWH---DLASKQNFTQSMVDD------VEKIRDGISEK 195
            .:::.|.|:|:|.:||:..:..|   ..:|   ||.|:.....|:|..      .:.:|..:|..
pombe   227 RLLSERIVSRLRARLFAKCMSLDGAFFDFHKHGDLISRLTTDSSIVGKSLSMYLSDGLRSSVSAI 291

  Fly   196 VGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLA 260
            .|      :|.::.|::      :||..:|..:|.:.|..::..::..||:...|::......::
pombe   292 AG------IGMMLYVSM------RLTGYMSLIVPPIALGAFFYGEYVRKLSRTTQDALGDLTRVS 344

  Fly   261 EEILSSIRTVVSFGGEKSEVQRY----ENFLVPARKASQWKGAFSG----LSDAVLKSMLYLS-- 315
            ||.|:::||..:|.||:.||.||    .|..|.|::.:...|.|.|    |.:|.:.::|.|.
pombe   345 EEKLANVRTTQAFLGERQEVNRYNDYIRNLFVLAKREAFASGIFFGSTGFLGNATVIAILALGGR 409

  Fly   316 --CAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLF 378
              .||....|                 .:.....:.:..|...:..:..|.: .....|.|:.||
pombe   410 MVAAGDITVG-----------------QLSSFLLYTVYAGGSIVGLSGCFTD-IMKGLGAASRLF 456

  Fly   379 KVIDLTSKIDPL------STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            :::|...||.|.      .|.||.:       :.|::|.|.||:||...:...|:..|..|..||
pombe   457 ELLDAKPKIAPTVGIPVPVTVGKAI-------LSFRNVGFAYPTRPSASIFDNLSFDIHPGTNVA 514

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNIS 502
            :|..||.||||..|||.|||.|..|.:|.|.:||..||:...||:..:||||||||.|||.:||:
pombe   515 IVAPSGGGKSTISQLLLRFYAPSSGKILADGVDISTYNVHQWRSHFGLVGQEPVLFSGTIGENIA 579

  Fly   503 YGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLL 567
            |||..|:|:|||.||.:|.. .|:.:.||.:.:.:|.||.||||||||||||||||::||..|:|
pombe   580 YGKSNASQEEIEDAAKRANC-SFVLSFPEKWSTQVGTRGLQLSGGQKQRIAIARALLRNPAFLIL 643

  Fly   568 DEATSALDYQSEKQVQQALD--LASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
            ||||||||.::|..|.:.:.  :.::..|||.::|:|:.||.||:|:.:.||||||:||.:.|..
pombe   644 DEATSALDGEAEVMVDKTIQSLMHNRSMTTITIAHKLATIRRADQIIVVGDGKVLEQGSFERLSR 708

  Fly   631 LEGAYYNMVR 640
            ....:|.::|
pombe   709 PGTNFYKLMR 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	187/593 (32%)
		ABC_membrane	108..354	CDD:279056	58/280 (21%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	116/238 (49%)
		ABC_membrane	736..1006	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216
mdl1	NP_595751.1	MdlB	141..723	CDD:224055	198/654 (30%)
		ABC_membrane	164..430	CDD:279056	64/332 (19%)
		P-loop_NTPase	484..720	CDD:304359	116/236 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I938
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910