Protein Alignment Mdr65 and mdl1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_595751.1
• Gene: mdl1 / 2541285
• PomBaseID: SPBC9B6.09C
• Length: 726
• Species: Schizosaccharomyces pombe
• Alignment Length: 725
• Identity: 211/725 - (29%)
• Similarity: 336/725 - (46%)
• Gaps: 164/725 - (22%)

  Fly     4 DEVSTSSSEG------KSQEEAPMAEGLEPTEPIAFLKL------------------FRFSTYGE 44
            :.:|..:|.|      |:....|.:..:.|...:|||||                  .:.:|.|.
pombe    70 NSLSQKASSGSKIYPFKNSFPLPFSRSILPIRSLAFLKLCVRHNSTVPSKDEQAQDISKINTNGT 134

  Fly    45 I-------------------GWLFF--GFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSN 88
            :                   ||.||  |.::.....:|:.   |.|      :|.:.:..|:|.
pombe   135 LQTPNKKVNVFRLFTLARGQGWNFFIAGSLLLVSSGVTMS---IPY------IVGKILDAGSSG- 189

  Fly    89 VHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFIS--GIF---------SVDVF 142
                                      |.|:::  ::.|.|...:|.  |:|         .:...
pombe   190 --------------------------DSSVTH--IMGIPSGTFYIGLLGLFFLGSACNFGRIITL 226

  Fly   143 NMVALRQVTRMRIKLFSSVIRQD---IGWH---DLASKQNFTQSMVDD------VEKIRDGISEK 195
            .:::.|.|:|:|.:||:..:..|   ..:|   ||.|:.....|:|..      .:.:|..:|..
pombe   227 RLLSERIVSRLRARLFAKCMSLDGAFFDFHKHGDLISRLTTDSSIVGKSLSMYLSDGLRSSVSAI 291

  Fly   196 VGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLA 260
            .|      :|.::.|::      :||..:|..:|.:.|..::..::..||:...|::......::
pombe   292 AG------IGMMLYVSM------RLTGYMSLIVPPIALGAFFYGEYVRKLSRTTQDALGDLTRVS 344

  Fly   261 EEILSSIRTVVSFGGEKSEVQRY----ENFLVPARKASQWKGAFSG----LSDAVLKSMLYLS-- 315
            ||.|:::||..:|.||:.||.||    .|..|.|::.:...|.|.|    |.:|.:.::|.|.
pombe   345 EEKLANVRTTQAFLGERQEVNRYNDYIRNLFVLAKREAFASGIFFGSTGFLGNATVIAILALGGR 409

  Fly   316 --CAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLF 378
              .||....|                 .:.....:.:..|...:..:..|.: .....|.|:.||
pombe   410 MVAAGDITVG-----------------QLSSFLLYTVYAGGSIVGLSGCFTD-IMKGLGAASRLF 456

  Fly   379 KVIDLTSKIDPL------STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            :::|...||.|.      .|.||.:       :.|::|.|.||:||...:...|:..|..|..||
pombe   457 ELLDAKPKIAPTVGIPVPVTVGKAI-------LSFRNVGFAYPTRPSASIFDNLSFDIHPGTNVA 514

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNIS 502
            :|..||.||||..|||.|||.|..|.:|.|.:||..||:...||:..:||||||||.|||.:||:
pombe   515 IVAPSGGGKSTISQLLLRFYAPSSGKILADGVDISTYNVHQWRSHFGLVGQEPVLFSGTIGENIA 579

  Fly   503 YGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLL 567
            |||..|:|:|||.||.:|.. .|:.:.||.:.:.:|.||.||||||||||||||||::||..|:|
pombe   580 YGKSNASQEEIEDAAKRANC-SFVLSFPEKWSTQVGTRGLQLSGGQKQRIAIARALLRNPAFLIL 643

  Fly   568 DEATSALDYQSEKQVQQALD--LASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
            ||||||||.::|..|.:.:.  :.::..|||.::|:|:.||.||:|:.:.||||||:||.:.|..
pombe   644 DEATSALDGEAEVMVDKTIQSLMHNRSMTTITIAHKLATIRRADQIIVVGDGKVLEQGSFERLSR 708

  Fly   631 LEGAYYNMVR 640
            ....:|.::|
pombe   709 PGTNFYKLMR 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	185/566 (33%)
		MdlB	711..1299	CDD:440747
mdl1	NP_595751.1	MdlB	146..723	CDD:440747	198/649 (31%)