DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and pmd1

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001342744.1 Gene:pmd1 / 2538709 PomBaseID:SPCC663.03 Length:1362 Species:Schizosaccharomyces pombe


Alignment Length:1374 Identity:455/1374 - (33%)
Similarity:697/1374 - (50%) Gaps:139/1374 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 STSSSEGKSQEE-------------APMAEGL-------EPTEPIAFLKLFRFSTYGEIGWLFFG 51
            ||..||.::.|.             .|..:.:       .|.:...:.::..::...:|.....|
pombe    34 STEKSENEASESHVVDVVKDPFEQYTPEEQEILYKQINDTPAKLSGYPRILSYADKWDIMLQLAG 98

  Fly    52 FIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDD 116
            .|......|.:|.:.::..:......|.|...|.||..|.:..|                .||  
pombe    99 TITGIGAGLGMPLMSLVSGQLAQAFTDLASGKGASSFQHTVDHF----------------CLY-- 145

  Fly   117 SISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSM 181
                  .:.||..|...|.|::| .|.:...|...|:|.....:::.|:||:.|.......|..:
pombe   146 ------FIYIAIGVFGCSYIYTV-TFIIAGERIARRIRQDYLHAILSQNIGYFDRLGAGEITTRI 203

  Fly   182 VDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLV---ILLNYYVAKFQG 243
            ..|...|:||:.||||...:.:..|:....|:|...||.||.:||..|.:   |.|.   ..|..
pombe   204 TTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFTLILSSMFPAICGGIGLG---VPFIT 265

  Fly   244 KLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVL 308
            |.|..:....|.:....||:.|:||...:||.:....:.|..:|:.|::....|....||....:
pombe   266 KNTKGQIAVVAESSTFVEEVFSNIRNAFAFGTQDILAKLYNKYLITAQRFGINKAIAMGLMVGWM 330

  Fly   309 KSMLYLSCAGAFWYGVNLI-IDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARG 372
            ..:.|.....|||.|..|: ..|.:|..       |:..||.:::.:.::|..:|.::||.:...
pombe   331 FFVAYGVYGLAFWEGGRLLHAGDLDVSK-------LIGCFFAVLIASYSLANISPKMQSFVSCAS 388

  Fly   373 CATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            .|..:|..||..|.|:..:..|.::. .::|::|.:::.|.||:||||:|....::...:|:..|
pombe   389 AAKKIFDTIDRVSPINAFTPTGDVVK-DIKGEIELKNIRFVYPTRPEVLVLDNFSLVCPSGKITA 452

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNIS 502
            |||:||.||||.:.|::|||||:.|.|.||..|:|..|:..||:.|::|.||||||..|:.:||:
pombe   453 LVGASGSGKSTIIGLVERFYDPIGGQVFLDGKDLRTLNVASLRNQISLVQQEPVLFATTVFENIT 517

  Fly   503 YGKP----GATQKE-----IEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARAL 558
            ||.|    |...||     :..||..|.|::||..|||.:.:.:|:||..:|||||||||||||:
pombe   518 YGLPDTIKGTLSKEELERRVYDAAKLANAYDFIMTLPEQFSTNVGQRGFLMSGGQKQRIAIARAV 582

  Fly   559 IQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEG 623
            |.:||||||||||||||.:||..||:|||.||:.|||||::||||.||.||.||.::.||::|:|
pombe   583 ISDPKILLLDEATSALDSKSEVLVQKALDNASRSRTTIVIAHRLSTIRNADNIVVVNAGKIVEQG 647

  Fly   624 SHDDLMALEGAYYNMVRA----GDINMPDEVEKE--------------DSIEDTKQKSL--ALFE 668
            ||::|:.|.|||..:|.|    |.....:.||:|              |..||....||  .:..
pombe   648 SHNELLDLNGAYARLVEAQKLSGGEKDQEMVEEELEDAPREIPITSFGDDDEDNDMASLEAPMMS 712

  Fly   669 KSFETSPLNFEKGQKNSVQFEEPIIK------------ALIKDTNAQSAEAPPEKPN-------- 713
            .:.:|..||.:..:|::|.||:..::            |.:.:.|.:..::...|.|        
pombe   713 HNTDTDTLNNKLNEKDNVVFEDKTLQHVASEIVPNLPPADVGELNEEPKKSKKSKKNNHEINSLT 777

  Fly   714 -------FFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR 771
                   |.||...|:       | |::|.::::..|..||..|.:|..|.....:....|.|.:
pombe   778 ALWFIHSFVRTMIEII-------C-LLIGILASMICGAAYPVQAAVFARFLNIFTDLSSTDFLHK 834

  Fly   772 TAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSA 836
            ..|.:...|.||.:......:..:...||...:..|:|...|..::.|:|.:||...|:|||::.
pombe   835 VNVFAVYWLILAIVQFFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFDRSENTVGAITT 899

  Fly   837 RLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSN 901
            .||.:...::|..|..|....|.|:|.||...:::...|||.|:.|:..|:|:.:.....:.:..
pombe   900 SLSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVRALDQ 964

  Fly   902 AVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEI---QRVEVLIRQKLRWRGVLNS 963
            ...:.....:|:...|.||.:.|||||.|.||.:|..||.:.:   .|...:...|   .|:..|
pombe   965 VQEKLSAAYKESAAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIASLK---SGLFFS 1026

  Fly   964 TMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL 1028
            ..|...|...|:...||..|:.:|:............:::|.....|...::...:.|..|...:
pombe  1027 AAQGVTFLINALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSADVTKAKAAAGEI 1091

  Fly  1029 FQILDRKPKIQSPMGTIKNTLAKQLNLFE--GVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVA 1091
            ..:.:.||||.:     .:|..|::...:  .:.:|.::|.||||...|:|.||:|.|..||.||
pombe  1092 KYLSESKPKIDT-----WSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGLNLTVKPGQFVA 1151

  Fly  1092 LVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENI 1156
            .||.|||||||.:.|::|:||.|.|.:.:|..::: |..::..|.::.:|||||||::.::.|||
pombe  1152 FVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVR-DYNINDYRKQIALVSQEPTLYQGTVRENI 1215

  Fly  1157 AYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKI 1221
            ..|.: :.||..|:|.|.|.||.|.||:.|||||:|..|.:|:.|||||||||||||||:|||||
pombe  1216 VLGAS-KDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQKGSSLSGGQKQRIAIARALIRNPKI 1279

  Fly  1222 LLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI 1286
            |||||||||||..||::||:||:.|..|||.:.||||||::|:||.|.|...|.:.|.|.|.:|:
pombe  1280 LLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSSIQDADCIFVFDGGVIAEAGTHAELV 1344

  Fly  1287 SQGGIYAKL 1295
            .|.|.|.:|
pombe  1345 KQRGRYYEL 1353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 437/1270 (34%)
ABC_membrane 108..354 CDD:279056 65/249 (26%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 129/249 (52%)
ABC_membrane 736..1006 CDD:279056 69/272 (25%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 125/237 (53%)
pmd1NP_001342744.1 AAA 139..1354 CDD:333001 437/1269 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 188 1.000 Domainoid score I741
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 767 1.000 Inparanoid score I79
OMA 1 1.010 - - QHG63700
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm46968
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
TreeFam 1 0.960 - -
1211.950

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