Protein Alignment Mdr65 and Tap2

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_114445.2
• Gene: Tap2 / 24812
• RGDID: 3818
• Length: 703
• Species: Rattus norvegicus
• Alignment Length: 648
• Identity: 200/648 - (30%)
• Similarity: 321/648 - (49%)
• Gaps: 115/648 - (17%)

  Fly   695 ALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAV-------- 751
            |::....||..|  |.:.|......|:|:|:|.:..:||        |.|::.|.||
  Rat   117 AVLSPAGAQEKE--PGQENNRALMIRLLRLSKPDLPFLI--------VAFIFLAMAVWGETLIPH 171

  Fly   752 --------IFGEFYAALAEKDPEDALRRTAVLSWACL---GLAFLTGLVCFLQTYLFNYAGIWLT 805
                    :.|:|       || ||.  .:.:.:.||   |.:...|  |...::||..:.|.|
  Rat   172 YSGRVIDILGGDF-------DP-DAF--ASAIFFMCLFSVGSSLSAG--CRGGSFLFTMSRINL- 223

  Fly   806 TRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVA 870
             |:|...|::::.|::.:|  :....|.|::|||.:...:...:.:..:.::::|...:......
  Rat   224 -RIREQLFSSLLRQDLAFF--QETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYYFM 285

  Fly   871 MYYNWKLALLCLANCPIIVGSVILEAKMMSN----AVVREKQ-VIEEACRIATESITNIRTVAGL 930
            :..:.:|..|.|.:.|:.:.     |:.:.|    ||::|.| |:.:|.::..|::..::||...
  Rat   286 LQVSPRLTFLSLLDLPLTIA-----AEKVYNPRHQAVLKEIQDVVAKAGQVVREAVGGLQTVRSF 345

  Fly   931 RREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTM-----QASAFFAYAVALCYG------GVLV 984
            ..|...:..|.|.::|.     ::|.||..|...:     :..|.....:.|..|      |.:.
  Rat   346 GAEEQEVSRYKEALERC-----RQLWWRRDLEKELYLVIRRVMALGMQVLILNCGVQQILAGEVT 405

  Fly   985 SEGQLPFQDIIKVSE--------TLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSP 1041
            ..|.|.|  ::...|        ..:||.|:            :.:.|..::|..|||:|.:..|
  Rat   406 RGGLLSF--LLYQEEVGHHVRNLVYMYGDML------------SNVGAAEKVFSYLDRRPNLPKP 456

  Fly  1042 MGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQ 1105
                 .|||..  ..|| |.::.:.|.||:||:..:|.||...:..|:..||||.:|.||||...
  Rat   457 -----GTLAPP--RVEGRVEFQDVSFSYPSRPEKPVLQGLTFTLHPGKVTALVGPNGSGKSTVAA 514

  Fly  1106 LLQRYYDPDEGTIHIDHDD-IQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVE 1169
            |||..|.|..|.:.:|.:. :|:|...  :..::.:|.|||.||..|:.:|||||  .|:....:
  Rat   515 LLQNLYQPTGGKVLLDGEPLVQYDHHY--LHRQVVLVGQEPVLFSGSVKDNIAYG--LRNCEDAQ 575

  Fly  1170 IIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQ 1234
            ::|||::|.|..||..:.||.:|.:|.||:||:.|||||:||||||||||::|:|||||||||.:
  Rat   576 VMAAAQAACADDFIGEMTNGINTEIGERGSQLAVGQKQRLAIARALVRNPRVLILDEATSALDAE 640

  Fly  1235 SEQLVQQALDT--ACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
            .|    |||.|  :...||.:||||||.||||||.:.|::.||:||   |.||..:..:||.|
  Rat   641 CE----QALQTWRSQEDRTMLVIAHRLHTVQNADQVLVLKQGQLVE---HDQLRDEQDVYAHL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	195/632 (31%)
Tap2	NP_114445.2	3a01208	1..697	CDD:273363	200/648 (31%)