DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr65 and Tap1

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_114444.2	Gene:	Tap1 / 24811	RGDID:	3817	Length:	725	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	191/626 - (30%)
Similarity:	313/626 - (50%)	Gaps:	83/626 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTL 101
            |..|..|.:..:....|:.|:..:.:|.       ||..:.|..:|..|:      |.|.....|
  Rat   156 FLDSKKGRLHLVLVLLILSCLGEMAIPF-------FTGRITDWILQDKTA------PSFARNMWL 207

  Fly   102 TNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDI 166
            .                   .:||:||..:..:|   ..::|:......:|:..::|.:|:.|:.
  Rat   208 M-------------------CILTVASTALEFAG---DGIYNITMGHMHSRVHGEVFRAVLHQET 250

  Fly   167 GWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLV 231
            |:.......:.|..:.:|...:.:.||:|:..|::.:...:..:|......:.||:.....:||:
  Rat   251 GFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAFMIWGSFYLTVVTLLSLPLL 315

  Fly   232 ILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQ- 295
            .||...:.|....|..:.|||.|.:..:|.|.||::.||.||..|:.|.|::...|...:..::
  Rat   316 FLLPRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKK 380

  Fly   296 ---------WKGAFSGLSDAVLK-SMLYLS----CAGAFWYGVNLIIDDRNVENKEYTPAI-LMI 345
                     |..:.||:   :|| .:|||.    ..||...| ||:  ...:...::|.|: :::
  Rat   381 EALAYVTEVWTMSVSGM---LLKVGILYLGGQLVVRGAVSSG-NLV--SFVLYQLQFTRAVEVLL 439

  Fly   346 AFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDV 410
            :.:                .|...:.|.:..:|:.:|.| ...|||  |.|....::|.|:||||
  Rat   440 SIY----------------PSMQKSVGASEKIFEYLDRT-PCSPLS--GSLAPLNMKGLVKFQDV 485

  Fly   411 FFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYN 475
            .|.||:.|.|.|.:||...:..|:..||||.:|.||||...|||..|.|..|.||||...:.:|:
  Rat   486 SFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGELLVQYD 550

  Fly   476 IQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGA-TQKEIEAAATQAGAHEFITNLPESYRSMIGE 539
            ..:|.:.:|.|||||:||..:..:||:||.... |.:||.|.|.::|||:||:..|:.|.:.:||
  Rat   551 HHYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEVGE 615

  Fly   540 RGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL----DLASKGRTTIVVSH 600
            .|:||||||:|.:|:|||||:.|::|:||:||||||..::.:||:.|    :.||  ||.::::.
  Rat   616 TGNQLSGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWAS--RTVLLITQ 678

  Fly   601 RLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRA 641
            :||....|..|:|:.:|.|.|:|:|..||...|.|.:||.|
  Rat   679 QLSLAERAHHILFLKEGSVCEQGTHLQLMERGGCYRSMVEA 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	180/572 (31%)
		ABC_membrane	108..354	CDD:279056	57/261 (22%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	109/242 (45%)
		ABC_membrane	736..1006	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	188/622 (30%)
		ABC_membrane	177..435	CDD:279056	65/298 (22%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	352..397		10/44 (23%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	430..464		7/50 (14%)
		P-loop_NTPase	469..697	CDD:304359	101/229 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910