DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr65 and Abcc1

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_071617.2 Gene:Abcc1 / 24565 RGDID:3112 Length:1532 Species:Rattus norvegicus


Alignment Length:1328 Identity:317/1328 - (23%)
Similarity:541/1328 - (40%) Gaps:254/1328 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 VHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQ---- 149
            :|.|.:|.|.:.|.......|:....|   ..|.|.|   .::|:|.....     :||.|    
  Rat   335 LHDLMMFAGPEILELIINFVNDREAPD---WQGYLYT---ALLFVSACLQT-----LALHQYFHI 388

  Fly   150 --VTRMRIK--LFSSVIRQDIGWHDLASKQNFTQSMVD----DVEKIRDGISEKVGHFVYLVVGF 206
              ||.||||  :..:|.|:.:...:.|.|.:....:|:    |.::..|     :..::.::...
  Rat   389 CFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD-----LATYINMIWSA 448

  Fly   207 IITVAISFSYGW-KLTLAVSSYIPLVILL------------NYYVAKFQGKLTAREQESYAGAGN 258
            .:.|.::..:.| .|..:|.:.:.::||:            .|.||..:.|         .....
  Rat   449 PLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSK---------DNRIK 504

  Fly   259 LAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAF-W- 321
            |..|||:.|:.:..:..|.:...:..|......|              |||...||:..|.| | 
  Rat   505 LMNEILNGIKVLKLYAWELAFQDKVMNIRQEELK--------------VLKKSAYLAAVGTFTWV 555

  Fly   322 ----------YGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATN 376
                      :.|.:.:|::|:.:.:  .|.:.:|.|.|:....||   .|.:.|.......:..
  Rat   556 CTPFLVALSTFAVFVTVDEKNILDAK--KAFVSLALFNILRFPLNI---LPMVISSIVQASVSLK 615

  Fly   377 LFKVIDLTSKIDPLS------TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQT 435
            ..::.....:::|.|      .||..:|     .:..::..|.: :|.|.....|:...|..|..
  Rat   616 RLRIFLSHEELEPDSIERWSIKDGGGMN-----SITVKNATFTW-ARDEPPTLNGITFAIPDGAL 674

  Fly   436 VALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQN 500
            ||:||..|||||:.:..|....|.|.|.|.             |:.::|.|.|:..:...::.:|
  Rat   675 VAVVGQVGCGKSSLLSALLAEMDKVEGHVT-------------LKGSVAYVPQQAWIQNDSLREN 726

  Fly   501 ISYGKPGATQKEIEAAATQAGA-HEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKI 564
            |.:|:|  .|:....|..:|.| ...:..||....:.|||:|..||||||||:::|||:..|..|
  Rat   727 ILFGRP--LQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDI 789

  Fly   565 LLLDEATSALDYQSEKQVQQ----ALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSH 625
            .|||:..||:|....|.:.:    .:.|. |.:|.|:|:|.:|.:...|.|:.:..||:.|.||:
  Rat   790 YLLDDPLSAVDAHVGKHIFEKVVGPMGLL-KNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSY 853

  Fly   626 DDLMALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEE 690
            .:|:..:||:...||. ..|...::..||   |:|.....|.::|         |..:|.:...:
  Rat   854 QELLDRDGAFAEFVRT-YANTEQDLASED---DSKNGVSGLGKES---------KPVENGILVTD 905

  Fly   691 PIIKALIKD----------TNAQ-SAEAPPEKPNFFRTFSRILQLAKQE---------WCYLILG 735
            .:.|.|.:.          ||.| |:.|..:|........::::..|.:         |.|:   
  Rat   906 AVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYM--- 967

  Fly   736 TISAVAVGFLYPAFAVIFGEFYAALAEK-------DPEDAL------RRTAVLSWACLGLAFLTG 787
              .|:.:...:.:..:......:|||..       |...|:      |...:..:..||:  |.|
  Rat   968 --KAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVYGALGI--LQG 1028

  Fly   788 LVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYP 852
            :..|..:...:..||:.:.|:.......::...:.:|  |....|.|..|.|.|...:...|...
  Rat  1029 VAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFF--ERTPSGNLVNRFSKELDTVDSMIPQV 1091

  Fly   853 LSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV---GSVILEAKMMSNAVVREKQVIEEAC 914
            :...:.:|.:.|.:|.:        .||......:|:   |.|....:....|..|:.:.:|...
  Rat  1092 IKMFMGSLFSVIGAVII--------ILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVS 1148

  Fly   915 RIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVA--- 976
            |....|..| .|:.|:    .|||.:.|:    |..|||     ..|.......|::...||   
  Rat  1149 RSPVYSHFN-ETLLGV----SVIRAFEEQ----ERFIRQ-----SDLKVDENQKAYYPSIVANRW 1199

  Fly   977 -----LCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFT----------PAFSAALIAGH 1026
                 .|.|..:|....| |..|.:.|.:.....:.::.||..|          ......::|..
  Rat  1200 LAVRLECVGNCIVLFAAL-FAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVE 1263

  Fly  1027 RL-----------FQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAK-ILN 1078
            ||           :||.:..|....|              ..| |.:|....||  |.|.. :|.
  Rat  1264 RLKEYSETEKEASWQIQETAPPSTWP--------------HSGRVEFRDYCLRY--REDLDLVLK 1312

  Fly  1079 GLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQ 1143
            .:::.:..|:.|.:||.:|.|||:....|.|..:..||.|.||..:|. .:.|..:|.|:.|:.|
  Rat  1313 HINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIA-KIGLHNLRFKITIIPQ 1376

  Fly  1144 EPTLFERSIAENI----AYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGG 1204
            :|.||..|:..|:    .|.|.       |:..|.:.|:...|:.:||:..:......|..||.|
  Rat  1377 DPVLFSGSLRMNLDPFSQYSDE-------EVWMALELAHLKGFVSALPDKLNHECAEGGENLSVG 1434

  Fly  1205 QKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVIC 1269
            |:|.:.:||||:|..|||:|||||:|:||:::.|:|..:.|.....|.:.|||||:|:.:...:.
  Rat  1435 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVI 1499

  Fly  1270 VIQNGQVVEQGNHMQLISQGGIYAKLHK 1297
            |:..|::.|.|...:|:.|.|::..:.|
  Rat  1500 VLDKGEIRECGAPSELLQQRGVFYSMAK 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 316/1326 (24%)
ABC_membrane 108..354 CDD:279056 56/282 (20%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 77/241 (32%)
ABC_membrane 736..1006 CDD:279056 58/293 (20%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 81/244 (33%)
Abcc1NP_071617.2 MRP_assoc_pro 7..1531 CDD:188098 317/1328 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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