Protein Alignment Mdr65 and ABCB10

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_036221.2
• Gene: ABCB10 / 23456
• HGNCID: 41
• Length: 738
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 221/620 - (35%)
• Similarity: 330/620 - (53%)
• Gaps: 52/620 - (8%)

  Fly   707 APPEKPNFFRTFS-------RILQLAKQEWCYLILGTISAVAVGFLYPAFAV------IFGEFYA 758
            |||......|..:       ::|.||..|...|      |.|||||..:..:      ..|:...
Human   139 APPGDKGRLRPAAAGLPEARKLLGLAYPERRRL------AAAVGFLTMSSVISMSAPFFLGKIID 197

  Fly   759 ALAEK---DPEDALRRTAVLSWACLGLA--FLTGLVC-FLQTYLFNYAGIWLTTRMRAMTFNAMV 817
            .:...   |..|.|.|      .||||:  ||.|... .::.||...:|..:..|:|...|::::
Human   198 VIYTNPTVDYSDNLTR------LCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSIL 256

  Fly   818 NQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCL 882
            .|||.:||  ....|.|..|||.:...:..::...||..::|.:.....:|:..:.:..||...|
Human   257 RQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVL 319

  Fly   883 ANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRV 947
            :..|.:....::..:.:.......:..:.:|.::|.|.|.|:|||....:|...|.:|..::..|
Human   320 SVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHV 384

  Fly   948 EVLIRQKLRWR-GVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQS 1011
            ..|.|::...| |...:|..:......:| |..||:|:....:   .:.::|..|:| :..:..|
Human   385 MQLARKEAFARAGFFGATGLSGNLIVLSV-LYKGGLLMGSAHM---TVGELSSFLMY-AFWVGIS 444

  Fly  1012 LAFTPAFSAALI----AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTR 1071
            :....:|.:.|:    ||.||:::|:|:||:....|.|.|..:     |:| :.::.:.|.||.|
Human   445 IGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKS-----FQGALEFKNVHFAYPAR 504

  Fly  1072 PDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRT 1136
            |:..|.....|.:..|...||||.||.||||.:.||.|.|||..|||.:|..||: .|....:|:
Human   505 PEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIR-QLNPVWLRS 568

  Fly  1137 KLGIVSQEPTLFERSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQ 1200
            |:|.|||||.||..||||||||| |:..||:..||...|:.|||.:||.:.|.|::|.:|.:|..
Human   569 KIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL 633

  Fly  1201 LSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNA 1265
            |||||||||||||||::|||||||||||||||.::|.|||:|||....|||.:||||||||::||
Human   634 LSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNA 698

  Fly  1266 DVICVIQNGQVVEQGNHMQLISQ-GGIYAKLHKTQ 1299
            :::.|:..|::.|.|.|.:|:|: .|||.||...|
Human   699 NMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	217/614 (35%)
ABCB10	NP_036221.2	mitochondrial targeting sequence	1..105
		MdlB	158..734	CDD:440747	217/601 (36%)