Protein Alignment Mdr65 and Abcc10

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001334325.1
• Gene: Abcc10 / 224814
• MGIID: 2386976
• Length: 1526
• Species: Mus musculus
• Alignment Length: 1408
• Identity: 310/1408 - (22%)
• Similarity: 546/1408 - (38%)
• Gaps: 355/1408 - (25%)

  Fly    50 FGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALY 114
            ||   ||..||.|..:|.....|:..|:              |.|..|       ..||..|.|
Mouse   282 FG---CCYLALGLLKMVGTMLGFSGPLL--------------LSLLVG-------FLEEGQEPL- 321

  Fly   115 DDSISYGILLTIASVVMFISGIFSVDVFNMV-------ALRQVT-RMRIKLFSSVIRQDIGWHDL 171
                |:|:|        ::.|:....|.:.|       .:|:|| :.|:.:.|::.|:
Mouse   322 ----SHGLL--------YVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRK------- 367

  Fly   172 ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGW--KLTLAVSSYI------ 228
            |.|...::....:|..:....||::.:|           |.||...|  .|.||::.|:
Mouse   368 ALKLGPSRPPTGEVLNLLGTDSERLLNF-----------AGSFHEAWGLPLQLAITLYLLYQQVG 421

  Fly   229 ----------PLVILLNYYVAKFQGKLTAREQESYA---GAGNLAEEILSSIRTVVSFGGEKSEV 280
                      .|::.:|..:|.   ::.|..||...   ....|..|:||.||.:..|
Mouse   422 MAFLAGLVLALLLVPVNKVIAT---RIMASNQEMLRHKDARVKLMTELLSGIRVIKFF------- 476

  Fly   281 QRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAF-WYGVNLIIDDRNVENKEYTPAILM 344
             |:|..|....||.:.|..      ..|:.:.||..|..: |..:               |.::.
Mouse   477 -RWEQALGDRVKACRTKEL------GRLRVIKYLDAACVYLWAAL---------------PVVIC 519

  Fly   345 IAFF--GIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSK-IDPLSTDGKLLNYGLRGDVE 406
            |..|  .:::|                .:..||.:|..:.|... |.||:....::|..|...|.
Mouse   520 ITIFITYVLMG----------------HQLTATKVFTALALVRMLILPLNNFPWVINGLLESKVS 568

  Fly   407 FQDV--FFRYPS-RPEVI--------------VHRGL---------------NIRIRAGQTVALV 439
            ...:  |...|| .||..              :|..|               :::::.|..|.:|
Mouse   569 LDRIQRFLDLPSYSPEAYYSPDPPAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGMLVGIV 633

  Fly   440 GSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYG 504
            |..|||||:.:..:......:.|.|.:.:|.          ....:..|||.:...||..||.:|
Mouse   634 GKVGCGKSSLLAAITGELHRLCGWVAVSELS----------KGFGLATQEPWIQCATIRDNILFG 688

  Fly   505 KPGATQ---KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILL 566
            |....|   :.:||.|    .::.::.||...::.:||:|..|||||:.|||:|||:.|...:.|
Mouse   689 KTFDAQLYREVLEACA----LNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYL 749

  Fly   567 LDEATSALDYQSEKQVQQALDLASKGRTT-IVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA 630
            ||:..:|:|......:.....|.....|| ::.:||...:..||.::.:..|:::..|...:::.
Mouse   750 LDDPLAAVDADVANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILP 814

  Fly   631 LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKA 695
            |..|           :|....:::.:..:.|          ..|..:.|:..:..::.|:.....
Mouse   815 LVQA-----------VPTAWAEKEQVATSGQ----------SPSVCDLERTTEEELEVEQSTCGC 858

  Fly   696 LI-KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLY------------- 746
            |: :::.::.|.|              |.:.:..|..:..|..:|:.|..|.
Mouse   859 LVQEESKSEGAVA--------------LHVYRAYWRAMGSGLAAAILVSLLLMQATRNGADWWLA 909

  Fly   747 ---------------------PAFAVIF---------GEFYAALAEKDPEDALRR-TAVLSWACL 780
                                 |....:|         |..|..|.......|... ||.:.:..:
Mouse   910 HWLSQLKAGRNGSREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLI 974

  Fly   781 GLAFLTG---LVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEA 842
            ..|.:.|   |...|:..||....:.....:.....:.::...|.::|  :...|.:..|.|.:.
Mouse   975 VYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYD--STPSGRVLNRFSSDV 1037

  Fly   843 VDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREK 907
            ..:..::.:.|:.:   |:|.:..:.:.......|..|.|...|:  ..|....:....|..||.
Mouse  1038 ACVDDSLPFLLNIL---LANSVGLLGLLAVLGSGLPWLLLLLPPL--SFVYYSVQGYYRASFREL 1097

  Fly   908 QVIEEACRIATESITNI-----RTVAGL--RREADVIREYTEEIQRVEVLIRQ-------KLRWR 958
            :      |:.:.:.:.:     .|:|||  .|.|.....:.||.||:..|.::       .::|.
Mouse  1098 R------RLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQWL 1156

  Fly   959 GVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFS---- 1019
            .:....|.|:...|.|     |..||...|       .::...|.| ::|:.:|:.|...|
Mouse  1157 DIRLQLMGAAVVSAIA-----GIALVQHQQ-------GLANPGLVG-LVLSYALSLTGLLSGLVS 1208

  Fly  1020 ------AALIAGHRLFQILDRKPK------IQSPMGTIKNTLAKQLNLFEGVRYRGIQFRY-PTR 1071
                  |.:::..||.:.....|:      :|||.....:.|.:     ..|.::.:...| |..
Mouse  1209 SFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPHQQRISWLTQ-----GSVEFQDVVLVYRPGL 1268

  Fly  1072 PDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRT 1136
            |:|  |:|:...|..|:.:.:||.:|.|||:...:|.|..:|:.|.:.:|:.|.. .|.|..:|:
Mouse  1269 PNA--LDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVDTS-QLELAELRS 1330

  Fly  1137 KLGIVSQEPTLFERSIAENI---AYGDNRR-------------SVSMVEIIAAAKS----ANAH- 1180
            :|.::.|||.||..:|.||:   ...::|.             :|:|.|..|..:|    .|.|
Mouse  1331 QLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQACQRSQREAKNGHW 1395

  Fly  1181 SFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDT 1245
            .....|..|.|..:|.||..||.||:|.:.:||||:.:.|||.:||||:::|.:::||:||.:..
Mouse  1396 QCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICK 1460

  Fly  1246 ACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQ 1288
            ..:.:|.:.|||||:|:.|:|.:.|:|.|:|||..:...|.:|
Mouse  1461 RFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQ 1503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	300/1367 (22%)
		ABC_membrane	108..354	CDD:279056	56/277 (20%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	66/272 (24%)
		ABC_membrane	736..1006	CDD:279056	56/330 (17%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	85/252 (34%)
Abcc10	NP_001334325.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000