DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr65 and haf-7

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_506645.1	Gene:	haf-7 / 190115	WormBaseID:	WBGene00001817	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	707	Identity:	217/707 - (30%)
Similarity:	338/707 - (47%)	Gaps:	102/707 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   632 EGAYY-----NMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEP 691
            |||.|     |...|.:.|:.:.....:....|...:.|....|            ::|...||
Worm   148 EGAEYERLTENTETAANTNVENGTASTNGTASTATPTAATSSTS------------RSSSTDEE- 199

  Fly   692 IIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEF 756
                   |.:|.|.|...::........:|::|...:|.:     .||        |:.::|.:.
Worm   200 -------DNDAVSKEEKEKRLPLLTHLWQIVKLCSVQWKW-----FSA--------AYVLLFVDC 244

  Fly   757 YAALAEKDPEDALRRTA-------VLSWACLGLA---FLTGLVCFLQTYLFNYAGIWLTTRMRAM 811
            ...|.|......:..||       ||..||:.||   |....|..::.....||.......:|..
Worm   245 ILNLIEPALYSQMMSTAIRMKSFDVLKRACIVLAAVQFTEATVNTVRYICMQYAERLTARNIRVS 309

  Fly   812 TFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWK 876
            .|.|:::|::.:|||  |..|.|.:|::.::..|..::...:...:........|..:..||:|:
Worm   310 LFRAILHQDISFFDD--NKTGQLMSRITKDSESISNSLPVYIETTVNNSFMLFGSAPIMFYYSWQ 372

  Fly   877 LALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESI----TNIRTVAGLRREADVI 937
            ||:......|||    :|..|.....|.:..:...:|..::.|::    :.||||.....|....
Worm   373 LAISTFVTFPII----LLTTKFYGLIVEKLSEKENDATAVSNETVEEVLSAIRTVRSFAAEKIEN 433

  Fly   938 REYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY----------AVALCYGGVLVSEGQLPFQ 992
            ..||.:..          .|..:...|:....||.|          .:...|||.|...|::...
Worm   434 MRYTRDTD----------AWFKISTKTVVFGTFFNYFWATMWNIEDVIIYLYGGYLTLNGRMEPD 488

  Fly   993 DIIKVSETLLYGSMMLAQSL-AFTPAFS---AALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQL 1053
            .::    |.::....|..:| ||:..||   ..:.:..::..|::|:|::....||....:...:
Worm   489 ALL----TYIFYHWRLHSALNAFSSLFSDVMKTIGSSRKVIHIMNRQPELDYEFGTETPEIVGNI 549

  Fly  1054 NLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTI 1118
             :||.|     :|.||||.:|.:||.::|.:..|:|:||||.||.||||.|.|:|::|.|..|.|
Worm   550 -IFEDV-----EFAYPTRKNANVLNKINLSIDPGKTIALVGPSGNGKSTLVSLIQQFYTPQSGRI 608

  Fly  1119 HIDHDDIQHDLTLDGV--RTKLGIVSQEPTLFERSIAENIAYG-DNRRSVSMVEIIAAAKSANAH 1180
            .||...||:   :|.:  .|.:.:|:||||||..::.|||.|| :|.....|:.:   |:.||.|
Worm   609 LIDGTPIQN---IDHLHYHTNIALVAQEPTLFSGTVRENILYGLENGTDEDMMRV---AEMANVH 667

  Fly  1181 SFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDT 1245
            .|:..:..||||:.|.:|.|:||||||||||||||:|:|::|:|||||||||.:||.:||:||:.
Worm   668 EFVSKMEKGYDTKCGEKGVQMSGGQKQRIAIARALIRDPRVLILDEATSALDSESEAMVQEALNR 732

  Fly  1246 ACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI-SQGGIYAKLHKTQKD 1301
            ....||.:|||||||||::||.|.||:.|.|.|.|||.:|: :..|:|.||...|.|
Worm   733 CARERTVLVIAHRLSTVRSADRIAVIEKGNVTEMGNHEELMKNTEGLYYKLVSKQLD 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	215/704 (31%)
		ABC_membrane	108..354	CDD:279056
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	5/14 (36%)
		ABC_membrane	736..1006	CDD:279056	62/293 (21%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	120/243 (49%)
haf-7	NP_506645.1	3a01208	17..784	CDD:273363	214/700 (31%)
		ABC_membrane	238..494	CDD:279056	59/275 (21%)
		ABC_MTABC3_MDL1_MDL2	549..787	CDD:213216	122/249 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810