DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and pgp-7

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1196	Identity:	354/1196 - (29%)
Similarity:	601/1196 - (50%)	Gaps:	107/1196 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EPTEPIAFLK-LFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNV 89
            :|.|..:|:: :|:.::..|......|.....:..|..|.|.....|...:||
Worm    20 KPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLV------------ 72

  Fly    90 HALPLFGGGKTLTNASREENNEAL-----------YDDSISYGILL--TIASVVMFISGIFSVDV 141
                      |:|||.   ||:.:           |:..: |.::|  .:.....|........:
Worm    73 ----------TITNAI---NNKTIDPADLKKAYEQYERGM-YQVVLYFFLCGCAYFTFASIQHAI 123

  Fly   142 FNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGF 206
            ...|......|:|.:..|.::|:|..:.|..|..:.:..:.|::|:.|:..:||:.....|:..|
Worm   124 MKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDF 188

  Fly   207 IITVAISFSYGWKLT---------LAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEE 262
            ::..|::|...|:|.         :|.|.:|....::         |.|.::...||.||::|.:
Worm   189 VVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVM---------KTTGKQNTHYANAGSIAFQ 244

  Fly   263 ILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAG----AFWYG 323
            .|.:.:||.|..|:.:|::||...|    ||.:..|....|..::.:...|..|..    ..:.|
Worm   245 TLGAYKTVCSLNGQNTEIERYTEEL----KAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVG 305

  Fly   324 VNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKID 388
            .|:|.      :....||:::..|..::.||..::...|.:...|   |..::...:.::..|.|
Worm   306 ANMIY------SGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLA---GAISSTAPIAEMLIKED 361

  Fly   389 PL----STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTC 449
            .:    .||.. :...:.|::.|::|.|.||:||:..|.:|::..::.|:.:||||:||.||||.
Worm   362 NVIEKDETDYD-VEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTV 425

  Fly   450 VQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIE 514
            ||||..:|:...|::.:|.:|:...||:.||..|.||.||||||..||.:||.:|.|..:..||.
Worm   426 VQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIY 490

  Fly   515 AAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSE 579
            .|..:|.|::|:.:.|:..::::||||:||||||||||||||.|::|||||||||||||||.:||
Worm   491 GALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESE 555

  Fly   580 KQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDI 644
            :.||:||:.||:|||||||:||||.||.|.||:.:..|:::|.|:||:|:|..|.|.::|:|
Worm   556 QVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA--- 617

  Fly   645 NMPDEVEKEDSIEDTKQKSLALFEKSFETSPLN---FEKGQKNSVQFEEPIIKALIKDTNAQSAE 706
               ..:|..|..|:.  ..||..:.|.|.|||:   .::...|.....:..::.::.:.:.:.|
Worm   618 ---QLLESHDDHEEL--PPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGA- 676

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR 771
               :|.|    ...|::..:.::|:|.:....:...|..||..|.:....|...| ...||.|..
Worm   677 ---KKSN----LREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA-MIGEDMLYY 733

  Fly   772 TAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSA 836
            :.:.:.:.:.||....|..:.|.|.|......|:||:|..:|:.|::....::||.|:|...||.
Worm   734 SHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSN 798

  Fly   837 RLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSN 901
            ||:.::.:::.|:...|..:|..:.....:::.|..|.||:.|..|...|::..:..........
Worm   799 RLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATET 863

  Fly   902 AVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQ 966
            ::..:....|.:.|.|.|::.|:|||..|..|..::...:|.:|::.....::...:|..|....
Worm   864 SIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSL 928

  Fly   967 ASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQI 1031
            :...|.|:|:..:|..|....::...|...:.|||...:.|...:.|:.|.:..|:.|...:|.:
Worm   929 SCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHL 993

  Fly  1032 LDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHS 1096
            ......:.......|..:.|...:.|.|     ||.|..|||..||||::|:|..|:|:||||.|
Worm   994 FTYPATMPFSSSDGKKNIEKGEIIGENV-----QFHYDQRPDRMILNGVNLKVDPGKTLALVGPS 1053

  Fly  1097 GCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDN 1161
            ||||||.:.||:|:|...:|.:.||.:::: |:.|:.:|:.|.:||||||||..||.||:.|| .
Worm  1054 GCGKSTIISLLERFYHAVDGEVKIDSENVE-DINLNHLRSNLALVSQEPTLFNCSIRENLLYG-L 1116

  Fly  1162 RRSVSMVEIIAAAKSANAHSFIISLP 1187
            .|||..:|:..|.::|||.:|:...|
Worm  1117 TRSVPQLELEKALQTANAFNFVFQFP 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	342/1130 (30%)
		ABC_membrane	108..354	CDD:279056	56/271 (21%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	122/236 (52%)
		ABC_membrane	736..1006	CDD:279056	62/269 (23%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	61/129 (47%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	200/633 (32%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	123/242 (51%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	70/308 (23%)
		TM helix 1	695..718	CDD:350022	5/22 (23%)
		TM helix 2	733..781	CDD:350022	12/47 (26%)
		TM helix 3	790..835	CDD:350022	10/44 (23%)
		TM helix 4	836..885	CDD:350022	9/48 (19%)
		TM helix 5	897..947	CDD:350022	9/49 (18%)
		TM helix 6	956..989	CDD:350022	8/32 (25%)
		P-loop_NTPase	1019..>1143	CDD:393306	62/131 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790