DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and Abcb1a

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_035206.2 Gene:Abcb1a / 18671 MGIID:97570 Length:1276 Species:Mus musculus


Alignment Length:1306 Identity:547/1306 - (41%)
Similarity:796/1306 - (60%) Gaps:67/1306 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWL-----FFGFIMCCIKALTLPAVVIIY 69
            |..||..::    |..|....::.|.:||::     |||     ..|.:...|..:.||.:::|:
Mouse    16 SKMGKKSKK----EKKEKKPAVSVLTMFRYA-----GWLDRLYMLVGTLAAIIHGVALPLMMLIF 71

  Fly    70 SEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALY----DDSISYGILLTIASVV 130
            .:.|.       .|.:..||        .|..||.| |.:..|::    ::..:|....|.....
Mouse    72 GDMTD-------SFASVGNV--------SKNSTNMS-EADKRAMFAKLEEEMTTYAYYYTGIGAG 120

  Fly   131 MFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEK 195
            :.|.....|..:.:.|.||:.::|.|.|.:::.|:|||.|:.........:.|||.||.:||.:|
Mouse   121 VLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDK 185

  Fly   196 VGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLA 260
            :|.|...:..|.....|.|:.||||||.:.:..|::.|.....||.....|.:|..:||.||.:|
Mouse   186 IGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVA 250

  Fly   261 EEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVN 325
            ||:|::||||::|||:|.|::||.|.|..|::....|...:.:|......::|.|.|.|||||.:
Mouse   251 EEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTS 315

  Fly   326 LIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
            |:|      :|||:...::..||.:::||.::.:.:|.:|:||.|||.|..:||:||....||..
Mouse   316 LVI------SKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSF 374

  Fly   391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQR 455
            |..|...: .::|::||:::.|.||||.||.:.:|||:::::||||||||:|||||||.|||:||
Mouse   375 SKSGHKPD-NIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQR 438

  Fly   456 FYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQA 520
            .|||:.|.|.:|..|||..|:::||..|.||.||||||..|||:||.||:...|..|||.|..:|
Mouse   439 LYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEA 503

  Fly   521 GAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQA 585
            .|::||..||..:.:::||||:||||||||||||||||::|||||||||||||||.:||..||.|
Mouse   504 NAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 568

  Fly   586 LDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAG-DINM 646
            ||.|.:||||||::||||.:|.||.|.....|.::|:|:||:||..:|.|:.:|   .|| :|.:
Mouse   569 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIEL 633

  Fly   647 PDEV-EKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPE 710
            .:|. :.:|.|:     :|.:..|...:|.:.....:|:.....:...|...|:  |...:.|| 
Mouse   634 GNEACKSKDEID-----NLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKE--ALDEDVPP- 690

  Fly   711 KPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTA-V 774
                 .:|.|||:|...||.|.::|...|:..|.|.|||:|||.:.........|.:..|:.: :
Mouse   691 -----ASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNL 750

  Fly   775 LSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLS 839
            .|...|.|..::.:..|||.:.|..||..||.|:|.|.|.:|:.|:|.||||..|:.|||:.||:
Mouse   751 FSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLA 815

  Fly   840 GEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVV 904
            .:|..::||.|..|:.:.|.::|..:.:.:::.|.|:|.||.||..|||..:.::|.||:|...:
Mouse   816 NDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL 880

  Fly   905 REKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASA 969
            ::|:.:|.:.:||||:|.|.|||..|.||......|.:.:|.......:|....|:..|..||..
Mouse   881 KDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMM 945

  Fly   970 FFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDR 1034
            :|:||....:|..||::..:.|::::.|...:::|:|.:.|..:|.|.::.|.::...:.:|:::
Mouse   946 YFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEK 1010

  Fly  1035 KPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGC 1098
            .|:|.|     .:|...:.|:.|| |::.|:.|.|||||...:|.||.|||.||||:||||.|||
Mouse  1011 TPEIDS-----YSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGC 1070

  Fly  1099 GKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRR 1163
            ||||.||||:|:|||..|::.:|..:|: .|.:..:|.:||||||||.||:.|||||||||||.|
Mouse  1071 GKSTVVQLLERFYDPMAGSVFLDGKEIK-QLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSR 1134

  Fly  1164 SVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEAT 1228
            .||..||:.|||.||.|.||.|||:.|:||:|.:||||||||||||||||||||.|.||||||||
Mouse  1135 VVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1199

  Fly  1229 SALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYA 1293
            ||||.:||::||:|||.|..|||||||||||||:||||:|.|||||:|.|.|.|.||::|.|||.
Mouse  1200 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYF 1264

  Fly  1294 KLHKTQ 1299
            .:...|
Mouse  1265 SMVSVQ 1270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 527/1220 (43%)
ABC_membrane 108..354 CDD:279056 80/249 (32%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 138/239 (58%)
ABC_membrane 736..1006 CDD:279056 90/270 (33%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 157/239 (66%)
Abcb1aNP_035206.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 3/13 (23%)
PTZ00265 47..1263 CDD:240339 533/1257 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..681 5/34 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 198 1.000 Domainoid score I3072
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.760

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