Protein Alignment Mdr65 and pgp-11

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001364583.1
• Gene: pgp-11 / 183971
• WormBaseID: WBGene00004005
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1319
• Identity: 399/1319 - (30%)
• Similarity: 639/1319 - (48%)
• Gaps: 202/1319 - (15%)

  Fly    53 IMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKT---LTNASREENNEALY 114
            ::|.:...|:..||:                          |.||..|   |||.:...|:|.||
 Worm    50 LICALLGGTIQPVVL--------------------------LIGGWITDLYLTNGNTAGNDEFLY 88

  Fly   115 D------DSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLAS 173
            .      ..:.:|:::.   |:..|.|:    .......|.:..:|.:...:|:|||..|.|..|
 Worm    89 SVLTLIYAGLGFGVIIL---VLALIQGV----CIQRGTSRILDSIRKEFLGAVLRQDANWLDKHS 146

  Fly   174 KQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFII----TVAISFSYGWKLTLAVSSYIPLVILL 234
            ..:.|..:.:::|.|.||:..|.   ..||.||.:    .:|.:| ..|:||....:..|:...:
 Worm   147 SGSITCQLNENIEVISDGLGNKC---CMLVRGFAMFTSSIIACAF-INWQLTFITFTMGPVSAFV 207

  Fly   235 NYYVAKF----QGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGE----------KSEVQRYEN 285
            .:.:.|.    ..:|.:...:|:|    :.||.:.::|||.|..|:          ..:::::.|
 Worm   208 LHLLTKVNEVSNEELMSLSAQSHA----IIEESILNVRTVQSCNGQNFMITKLNQVNEKIKKFYN 268

  Fly   286 FLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPA--ILMIA-- 346
                  |::.|.|.|.||:..|:          .|..|::|....|...|:|...|  :::|.
 Worm   269 ------KSTFWAGFFDGLALFVI----------YFITGISLFFGCRLYFNQEIGKAGDVILIVNT 317

  Fly   347 ------FFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDV 405
                  |.|::         .|.:.|...|......|:|.|:...|.:  ..:|::.....||::
 Worm   318 ICVTGYFLGLL---------GPHMSSLQQAATSFLLLYKTIESAPKSE--GKEGEIKISSTRGNI 371

  Fly   406 EFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLD 470
            ||:||.|:|.:|...:: :||::::..||||||||:|||||||.:.||.:.|....|.:|:|..:
 Worm   372 EFRDVRFKYFTRDNEVL-QGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEGEILIDGKN 435

  Fly   471 IRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRS 535
            |...:.:.||..|.:|.|||.||.|||.:||..|: ...::.|:.||..|.|..||..|...|.:
 Worm   436 IDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGR-NVDEETIKTAADIANASSFIEKLENGYET 499

  Fly   536 MIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSH 600
            .:|..|.||||||||||.|||||:.:|.||||||||||||..:|..|.:||..||:|||||:::|
 Worm   500 RLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSHNEHIVNKALTKASEGRTTIIIAH 564

  Fly   601 RLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLA 665
            |||:::..|:|..:..||..|.|:||:|:.|.|.|..:.::      .||| :.|.:|.:::.|.
 Worm   565 RLSSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARLAKS------QEVE-QSSKKDWEREELR 622

  Fly   666 LFEKSFETSPLNFEKGQKNSVQFEEP-----------IIKALIKDTNAQSAEAPPEKPNFFRTFS 719
            ..||.         |.:..:|:..||           .:.::|.:...|..           :||
 Worm   623 RAEKM---------KKKGRTVEIIEPNSTILQEHEHNFVGSVITENEEQKI-----------SFS 667

  Fly   720 RILQL-----AKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWAC 779
            .|.:|     ..::...||:..:...|:........:.|. |......||.        .::|..
 Worm   668 GISKLFNYLPKHRKTLILIIALLIPRAIELCSYGIGMSFA-FKTLQRSKDD--------YMTWNY 723

  Fly   780 LGLA--FLTGLVCF-LQTYLFNYAGIWLT----TRMRAMTFNAMVNQEVGWFDDENNSVGALSAR 837
            :.||  .|.|:..: |.|.|....| ||.    ..::....:.::|:.:.:||:...|..|..:|
 Worm   724 ITLAQQTLAGITFWILHTSLMYLCG-WLANEVMNEVKQEMLSEVLNKPIPYFDNPETSPSACVSR 787

  Fly   838 LSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNA 902
            :...|.:....:.:.....:..::..|.|:.:|..:.|:|.:|.| ...|::....|....:::.
 Worm   788 IISHAHNCYACLDHRAIRFVWFIAGTIFSLLLAFPFVWELGVLGL-GITILLTIFSLHFVSVAHR 851

  Fly   903 VVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQA 967
            ...||.|::::...|.|.:.:||.:..|..|.....:::|.::..|: ...|:.:...||..:..
 Worm   852 AHSEKSVMDKSGEFAVEIVEHIRAIKLLAVEGYFENKFSEYLKTSEI-YENKIGFVSSLNFAITQ 915

  Fly   968 SAFFAYAVALCY-GGVLVSEGQ-------LPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIA 1024
            |..||..:.|.: |.:|:..|:       |.|.           |:.|.|..:.:...:...::.
 Worm   916 SYVFACDMLLFFVGTLLIYHGRYSPDKVFLAFN-----------GAQMSAWGVMYFSPWFPEIVR 969

  Fly  1025 G----HRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVL 1085
            |    :::|...| |.:..|..|..|..:..::.:.:      :.|.||:.|...:..|..|.:.
 Worm   970 GSASANQIFSFFD-KNRTNSTSGLSKPEINGKVEVSD------VTFAYPSTPHRNVCEGFSLNIP 1027

  Fly  1086 KGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFER 1150
            ||.::||||.|||||||.:.:|:|:|....|.|.:|.:||. .:.::.:|..:.:|.|||.||..
 Worm  1028 KGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDID-GIDVNHLRNNISVVGQEPVLFNA 1091

  Fly  1151 SIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARAL 1215
            :|.|||..|.:  .||:.|:..|.|:|||..||.|.|.||||.:|..|..||||||||||||||:
 Worm  1092 TIRENITIGID--EVSVEEVQKACKAANAAGFIESFPLGYDTIVGEGGASLSGGQKQRIAIARAI 1154

  Fly  1216 VRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQG 1280
            :|.||||||||||||||.|||::||:||.:|.:|||.|::||||||||:.|.|..|..|.|.|.|
 Worm  1155 IRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLSTVQHCDTIYYISRGAVAEYG 1219

  Fly  1281 NHMQLISQGGIYAKLHKTQ 1299
            .|.:|::....||:|...|
 Worm  1220 THAELVAMDSKYARLVAAQ 1238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	395/1281 (31%)
		ABC_membrane	108..354	CDD:279056	62/279 (22%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	112/236 (47%)
		ABC_membrane	736..1006	CDD:279056	56/284 (20%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	118/239 (49%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	397/1314 (30%)
		MdlB	46..607	CDD:224055	195/632 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790