DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and pgp-14

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_510128.1 Gene:pgp-14 / 181416 WormBaseID:WBGene00004008 Length:1327 Species:Caenorhabditis elegans


Alignment Length:1319 Identity:465/1319 - (35%)
Similarity:702/1319 - (53%) Gaps:129/1319 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV---DRAMQFGTSSNVH 90
            :|::...|||:....:...||.|.|...|..::.|.:.::....|:.|:   ..:.||       
 Worm    86 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF------- 143

  Fly    91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRI 155
                           |.:.||.:| ..:..||.::|.:.:.::       .|.....|.:.:||.
 Worm   144 ---------------RNKANENVY-IFLGIGIFISITNFIQYM-------CFQHCCTRVMAQMRH 185

  Fly   156 KLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGF---IITVAISFSYG 217
            :...||:||:.||.|.......|..:.|.:|:||:||.:|:|   .|:.||   |..:.:::.|.
 Worm   186 RFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLG---VLLRGFAMLIAAIVVAYIYE 247

  Fly   218 WKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQR 282
            |:|...:....|...:....:|:.....|.:|......||::|||.|..:|||.:|.|::..|.|
 Worm   248 WRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGR 312

  Fly   283 YENFLVPARKASQWKGAFSGLSDAVLKSML--YLSCA---GAFWYGVNLIIDDRNVENKEYTPAI 342
            ||..|...||.:.|||.:||....:....|  :|.|.   ||:...|.:|.          ||..
 Worm   313 YEAELEKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIIT----------TPGD 367

  Fly   343 LMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEF 407
            :.|....:::||..:...:|.:.....||..|.::::.||...||||.|..||.|. .:.|.|:|
 Worm   368 VFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ-NVVGRVKF 431

  Fly   408 QDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIR 472
            ::|.||||||.:..:..|||:.:..|.:|||||.|||||||.|.||.|.|:|..|:|.:|..|:|
 Worm   432 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 496

  Fly   473 KYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMI 537
            :.||:|||:.:.:|.|||:||..||..|:..|.||:|::.:......|.||:||..:|:.|.::|
 Worm   497 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLI 561

  Fly   538 GERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRL 602
            |:.|.|||||||||:||||.||::||:|||||||||||.|||..||.||:.||||||||:::|||
 Worm   562 GDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRL 626

  Fly   603 SAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRA----GDINMPDEVEKED-SIEDTKQK 662
            |.||.||||||...|.::|.|:|::|:.|.|.|:::|:|    .|....:|.|:|: .::||.:.
 Worm   627 STIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFEEEEIDLDDTSRS 691

  Fly   663 SLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRT---------- 717
            |......|..:....|.:|...:..|          ..:.:||:|..|...|...          
 Worm   692 SRRSSMTSARSGSEAFRRGNSLNDSF----------SGSKRSAQADAENSAFAANEAAIMAEDGQ 746

  Fly   718 ----FSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR---TAVL 775
                :..|.:.||..:.|:.|||:.|:..|...||.|:|||..:...........:..   .||:
 Worm   747 ITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVI 811

  Fly   776 SWACLGLAFLTGLVCFLQ---TYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSAR 837
            ::|.:|:.     |.|.|   :.||......|:.|.|..:|..::.|:..:||:..::.|.|..|
 Worm   812 AFASVGVG-----VWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITR 871

  Fly   838 LSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNA 902
            |:.:|.:|:..:...:..:|.||:..|:::::|..|.|::.:|..:...::...:|..|..:|..
 Worm   872 LASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGTSLILLLAFVMIGLAYKISLM 936

  Fly   903 VVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLN----S 963
            .|.:.| .::|.|||.|.|.|::|:..|.|.......|....::.:   |.:|: :|::.    |
 Worm   937 NVEQIQ-NDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQK---RSELK-KGMIEAINYS 996

  Fly   964 TMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL 1028
            ..|:..:|........|..::.:|.....|..|....::.|::.:..|..:.|.|..|..|...|
 Worm   997 LTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGML 1061

  Fly  1029 FQILDRKPKIQSPMGTIKNTLAKQLNLFEGVR--------YRGIQFRYPTRPDAKILNGLDLEVL 1085
            |.|:.|||:..              :|.||.|        :..::|.||.||...|:.||....|
 Worm  1062 FNIIYRKPRTG--------------DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTAL 1112

  Fly  1086 KGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFER 1150
            :||||||||.||.||||.:.:|:|:||...|.:.||..||: .|:|..:||::.:|.|||.||..
 Worm  1113 RGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIR-KLSLFHLRTQMALVGQEPRLFAG 1176

  Fly  1151 SIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARAL 1215
            :|.||:..|  .:.|.:.:|..|.:.|||:.|:.:||.|.||.:|.:|.||||||||||||||||
 Worm  1177 TIRENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARAL 1239

  Fly  1216 VRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQG 1280
            ||:||||||||||||||.:||:.||:|||.|..|||||.||||||::||:|:|..|..|:|.|.|
 Worm  1240 VRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAG 1304

  Fly  1281 NHMQLISQGGIYAKLHKTQ 1299
            ||.||:.|.|.|.||.|.|
 Worm  1305 NHTQLMHQKGRYYKLIKKQ 1323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 451/1254 (36%)
ABC_membrane 108..354 CDD:279056 70/253 (28%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 129/240 (54%)
ABC_membrane 736..1006 CDD:279056 66/279 (24%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 131/247 (53%)
pgp-14NP_510128.1 PTZ00265 104..1321 CDD:240339 459/1297 (35%)
ABC_membrane 109..377 CDD:279056 78/310 (25%)
ABC_MTABC3_MDL1_MDL2 429..666 CDD:213216 128/236 (54%)
ABC_membrane 769..1039 CDD:294371 66/279 (24%)
ABC_MTABC3_MDL1_MDL2 1086..1323 CDD:213216 130/239 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.790

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