Protein Alignment Mdr65 and pgp-14

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_510128.1
• Gene: pgp-14 / 181416
• WormBaseID: WBGene00004008
• Length: 1327
• Species: Caenorhabditis elegans
• Alignment Length: 1319
• Identity: 465/1319 - (35%)
• Similarity: 702/1319 - (53%)
• Gaps: 129/1319 - (9%)

  Fly    29 EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV---DRAMQFGTSSNVH 90
            :|::...|||:....:...||.|.|...|..::.|.:.::....|:.|:   ..:.||
 Worm    86 QPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQF------- 143

  Fly    91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRI 155
                           |.:.||.:| ..:..||.::|.:.:.::       .|.....|.:.:||.
 Worm   144 ---------------RNKANENVY-IFLGIGIFISITNFIQYM-------CFQHCCTRVMAQMRH 185

  Fly   156 KLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGF---IITVAISFSYG 217
            :...||:||:.||.|.......|..:.|.:|:||:||.:|:|   .|:.||   |..:.:::.|.
 Worm   186 RFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLG---VLLRGFAMLIAAIVVAYIYE 247

  Fly   218 WKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQR 282
            |:|...:....|...:....:|:.....|.:|......||::|||.|..:|||.:|.|::..|.|
 Worm   248 WRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGR 312

  Fly   283 YENFLVPARKASQWKGAFSGLSDAVLKSML--YLSCA---GAFWYGVNLIIDDRNVENKEYTPAI 342
            ||..|...||.:.|||.:||....:....|  :|.|.   ||:...|.:|.          ||..
 Worm   313 YEAELEKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIIT----------TPGD 367

  Fly   343 LMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEF 407
            :.|....:::||..:...:|.:.....||..|.::::.||...||||.|..||.|. .:.|.|:|
 Worm   368 VFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQ-NVVGRVKF 431

  Fly   408 QDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIR 472
            ::|.||||||.:..:..|||:.:..|.:|||||.|||||||.|.||.|.|:|..|:|.:|..|:|
 Worm   432 ENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVR 496

  Fly   473 KYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMI 537
            :.||:|||:.:.:|.|||:||..||..|:..|.||:|::.:......|.||:||..:|:.|.::|
 Worm   497 ELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLI 561

  Fly   538 GERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRL 602
            |:.|.|||||||||:||||.||::||:|||||||||||.|||..||.||:.||||||||:::|||
 Worm   562 GDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRL 626

  Fly   603 SAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRA----GDINMPDEVEKED-SIEDTKQK 662
            |.||.||||||...|.::|.|:|::|:.|.|.|:::|:|    .|....:|.|:|: .::||.:.
 Worm   627 STIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFEEEEIDLDDTSRS 691

  Fly   663 SLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRT---------- 717
            |......|..:....|.:|...:..|          ..:.:||:|..|...|...
 Worm   692 SRRSSMTSARSGSEAFRRGNSLNDSF----------SGSKRSAQADAENSAFAANEAAIMAEDGQ 746

  Fly   718 ----FSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR---TAVL 775
                :..|.:.||..:.|:.|||:.|:..|...||.|:|||..:...........:..   .||:
 Worm   747 ITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVI 811

  Fly   776 SWACLGLAFLTGLVCFLQ---TYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSAR 837
            ::|.:|:.     |.|.|   :.||......|:.|.|..:|..::.|:..:||:..::.|.|..|
 Worm   812 AFASVGVG-----VWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITR 871

  Fly   838 LSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNA 902
            |:.:|.:|:..:...:..:|.||:..|:::::|..|.|::.:|..:...::...:|..|..:|..
 Worm   872 LASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGTSLILLLAFVMIGLAYKISLM 936

  Fly   903 VVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLN----S 963
            .|.:.| .::|.|||.|.|.|::|:..|.|.......|....::.:   |.:|: :|::.    |
 Worm   937 NVEQIQ-NDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQK---RSELK-KGMIEAINYS 996

  Fly   964 TMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL 1028
            ..|:..:|........|..::.:|.....|..|....::.|::.:..|..:.|.|..|..|...|
 Worm   997 LTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGML 1061

  Fly  1029 FQILDRKPKIQSPMGTIKNTLAKQLNLFEGVR--------YRGIQFRYPTRPDAKILNGLDLEVL 1085
            |.|:.|||:..              :|.||.|        :..::|.||.||...|:.||....|
 Worm  1062 FNIIYRKPRTG--------------DLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTAL 1112

  Fly  1086 KGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFER 1150
            :||||||||.||.||||.:.:|:|:||...|.:.||..||: .|:|..:||::.:|.|||.||..
 Worm  1113 RGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIR-KLSLFHLRTQMALVGQEPRLFAG 1176

  Fly  1151 SIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARAL 1215
            :|.||:..|  .:.|.:.:|..|.:.|||:.|:.:||.|.||.:|.:|.||||||||||||||||
 Worm  1177 TIRENVCLG--LKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARAL 1239

  Fly  1216 VRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQG 1280
            ||:||||||||||||||.:||:.||:|||.|..|||||.||||||::||:|:|..|..|:|.|.|
 Worm  1240 VRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAG 1304

  Fly  1281 NHMQLISQGGIYAKLHKTQ 1299
            ||.||:.|.|.|.||.|.|
 Worm  1305 NHTQLMHQKGRYYKLIKKQ 1323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	212/530 (40%)
		MdlB	711..1299	CDD:440747	218/619 (35%)
pgp-14	NP_510128.1	MdlB	93..667	CDD:440747	230/617 (37%)
		PTZ00265	104..1321	CDD:240339	459/1297 (35%)