Protein Alignment Mdr65 and pgp-12

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_510126.1
• Gene: pgp-12 / 181415
• WormBaseID: WBGene00004006
• Length: 1318
• Species: Caenorhabditis elegans
• Alignment Length: 1335
• Identity: 464/1335 - (34%)
• Similarity: 699/1335 - (52%)
• Gaps: 158/1335 - (11%)

  Fly    29 EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV----------DRAMQF 83
            :|:..|.|||::...:...|.||..:..|..:..|.:.||....|:.|:          |.||
 Worm    74 KPVTLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAM-- 136

  Fly    84 GTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALR 148
               :||.   ||||                      .||::.|.:.|.::       .|....:|
 Worm   137 ---TNVW---LFGG----------------------IGIIVLIVNFVQYM-------CFQYCCIR 166

  Fly   149 QVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAIS 213
            ..::|:.....|::||:.||.|.......|..:.|::|:|.:||.:|:|..:..:|.|:..:.||
 Worm   167 ITSKMKQHYIQSILRQNAGWFDKNHSGTLTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVIS 231

  Fly   214 FSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKS 278
            |.|.|:|.|.:....||..:....:::.....|::|......||::|||.|..:|||.:|.|::.
 Worm   232 FFYEWRLALMMMGIGPLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEE 296

  Fly   279 EVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNL----IIDDRNVENKEYT 339
            .|::|...|...:..:..||.:.|:...:....|:....|..:||..|    ||:         |
 Worm   297 MVEKYTVELGKGKSFAIQKGLWGGVFGGIFLLFLFSYFGGGIYYGGQLLRWKIIE---------T 352

  Fly   340 PAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDG-KLLNYGLRG 403
            |..:.|....:::||..:...:|.|.....||..|..::::||.|..||..||:| |:.|  :.|
 Worm   353 PGDVFIVVISMLIGAYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTN--VVG 415

  Fly   404 DVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDD 468
            .|.|::|.||||:|.:|.|..|||:.::.|.:|||||.|||||||.|.||.|.|:|..|.|::|.
 Worm   416 KVVFEEVHFRYPTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDG 480

  Fly   469 LDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESY 533
            .|:|..||.|||..:.:|.|||:||..||..|:..|.|.||::::......|.||:||..:|..|
 Worm   481 QDVRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGY 545

  Fly   534 RSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVV 598
            .:|||:...|||||||||:||||.||::||:|||||||||||.|||..||.||:.|:||||||::
 Worm   546 ETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMI 610

  Fly   599 SHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEK--EDSIEDTKQ 661
            :||||.||.||||||..:|.::|.|:|::|:||.|.|..:|.|......|::|.  ::..|:|..
 Worm   611 AHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNGDEHEEETST 675

  Fly   662 ------------------KSLAL------FEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNA 702
                              :|||.      :..:|.|..|...:.:..:..|.|.:.:.:.:|...
 Worm   676 VGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENEDFAEEVQRVMEEDGVI 740

  Fly   703 QSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPED 767
            .|.            :..|.:.|:..:.||.:||..|:..|......|.:||..:||.  |:|||
 Worm   741 NSG------------YLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAF--KEPED 791

  Fly   768 ALRRTAVLSWACLGLAFL----TGLVCFLQTY----LFNYAGIWLTTRMRAMTFNAMVNQEVGWF 824
            .:.:       .|||.|:    .||..|:...    ||......|..:.|..:|..::.|:..:|
 Worm   792 EMVK-------ALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDASFF 849

  Fly   825 DDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV 889
            |:..::.|.|..||:.:|.:::..:...:..:|.::::...::.....:.|::|         |.
 Worm   850 DNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIA---------IA 905

  Fly   890 GS--VILEAKM---MSNAVVRE--KQV-IEEACRIATESITNIRTVAGLRREADVIREYTEEIQR 946
            |:  ::|.|.|   |:..:.||  ||: .:||.:||.|.|.:::|:..|......:..|.:
 Worm   906 GTIMIVLFATMMISMAYKIARENLKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKD---- 966

  Fly   947 VEVLIRQKLRWR-----GVLNSTMQASAFFAYAVALCYG-GV-LVSEGQLPFQDIIKVSETLLYG 1004
             ..|::.|...|     .|.|:..|  .|..:|:.:||| |. |:..|.:..:...:....::.|
 Worm   967 -AQLVQHKSEMRKSYIQSVNNAISQ--TFMYFAMFVCYGVGTPLMYHGIVEAEPTFRAINCMMMG 1028

  Fly  1005 SMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYP 1069
            |:.:..|....|.|..|..|...||:::.||.|....|.. .||..:...|||.|:     |.||
 Worm  1029 SVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSKTGDVMEG-NNTEIRGNVLFESVK-----FSYP 1087

  Fly  1070 TRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGV 1134
            .||...::..|......||||||||.||.|||||:.:|:|:||...|.:.||..:|: .|:|..:
 Worm  1088 QRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIK-SLSLHHL 1151

  Fly  1135 RTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGT 1199
            ||::.:|.|||.||..:|.||:.:|  .:.||:.::..|.:.|||..|:.:||.|.||.:|.:|.
 Worm  1152 RTQMALVGQEPRLFAGTIKENVCFG--LKDVSVEKVHQALELANASRFLANLPAGIDTEVGEKGG 1214

  Fly  1200 QLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQN 1264
            ||||||||||||||||||:||||||||||||||.:||:.||:|||.|..|||||.||||||::||
 Worm  1215 QLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQN 1279

  Fly  1265 ADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            :|:|..|.:|.|.|.|||..|:|..|.|..|.|.|
 Worm  1280 SDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQ 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	208/527 (39%)
		MdlB	711..1299	CDD:440747	217/610 (36%)
pgp-12	NP_510126.1	MdlB	77..654	CDD:440747	230/624 (37%)
		PTZ00265	145..1312	CDD:240339	439/1230 (36%)