DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and pgp-4

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001257142.1 Gene:pgp-4 / 181327 WormBaseID:WBGene00003998 Length:1280 Species:Caenorhabditis elegans


Alignment Length:1313 Identity:472/1313 - (35%)
Similarity:729/1313 - (55%) Gaps:71/1313 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 DEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVII 68
            :.|...|...|.::::..::|      .:...|||.|...:...|..|.::.......||...:|
 Worm    20 EHVELGSRPDKKKKKSRSSQG------NSLSNLFRHSGCADYLLLLGGLVLSAANGALLPFNSLI 78

  Fly    69 YSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSIS----YGILLTIASV 129
            :...|::|:....|:                        :|....||...|    |.:|..:..|
 Worm    79 FEGITNVLMKGEAQW------------------------QNGTFDYDTFSSGIQHYCLLYFLLGV 119

  Fly   130 VMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISE 194
            :||....||......:|.|::..:|..|..||:|||..|.|..:....||.|...:|||:|||.:
 Worm   120 LMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQDAKWFDENTVGGLTQKMSSGIEKIKDGIGD 184

  Fly   195 KVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNL 259
            |:|..|..:..||..||:.|...|:|||.:...:||.:...|..||...:.|..|..:|:.||.:
 Worm   185 KIGVLVSGIATFISGVALGFYMCWQLTLVMLVTVPLQLGSMYLSAKHLNRATKNEMSAYSSAGGM 249

  Fly   260 AEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGV 324
            |.|:::.||||::|..:..|::||...|..|||....|.....|..|:...::::..|||||||.
 Worm   250 ANEVIAGIRTVIAFNAQPFEIERYGAQLAKARKMGIRKAIVLALCSAMPLFLMFVLMAGAFWYGA 314

  Fly   325 NLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDP 389
              |:....|.....|..:    |:.:|:|...:...||.:.:...||....::|||||...:|:.
 Worm   315 --ILTSYGVATSGTTFGV----FWAVILGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINC 373

  Fly   390 LSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQ 454
            ...:|:..: .:.|.:.|.::.|.||:||:|.:.:|::..:..|:|:||||.|||||||.:.||.
 Worm   374 TKQEGRRPD-KVNGKLVFDNIQFTYPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLM 437

  Fly   455 RFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQ 519
            |||:...||:.||.:.|..||||||||.|.:|.|||::||.|:|:|:..|....|.|:||.|..|
 Worm   438 RFYNQCAGSIKLDGIPIEDYNIQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQ 502

  Fly   520 AGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQ 584
            |.||:||..|.|.|.::||....|||||||||:|||||:::.|:||||||||||||.:||:.||.
 Worm   503 ANAHDFIGKLSEGYNTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQT 567

  Fly   585 ALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDIN--MP 647
            |||.||:||||:.::||||.||.|.||:....|.:.|.|.||.|:...|.|.|||||.:|.  ..
 Worm   568 ALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQEIEKAKD 632

  Fly   648 DEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQ---KNSVQFEEPI--IKALIKDTNAQSA-E 706
            |..:.:|.:.:....|::   :...||.....|.:   ::|.:|.:.:  :.:.:.|...:|| |
 Worm   633 DTTQDDDELVEEDNYSIS---RRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESARE 694

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR 771
            ...|:.....:...|.:.||.|...:::..|..:..|..:|||:|::|:.:...|| ..|| |..
 Worm   695 EMIEEGAMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAE-GGED-LPV 757

  Fly   772 TAVLS--WACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGAL 834
            .|::|  |..| ||..:.:..|:...|....|..:::|:|...|..::.|:..:|||..::||.|
 Worm   758 NALISSLWFVL-LAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFDDPKHNVGNL 821

  Fly   835 SARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMM 899
            ::||:.::.::|.||.:.|:.::..:.:..:.::||.::.|.:|.:.|....::|.:....|:.:
 Worm   822 TSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITALLLVIAQSAVAQYL 886

  Fly   900 SNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNST 964
            .....::.:...||.||.||||:|.:||..|.::..:...:|...:........|..|:.:  |.
 Worm   887 KYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAFTAASKNPRKRAFTKGLWQSL--SF 949

  Fly   965 MQASAFFA--YAVALCYGGVLVSEG-QLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGH 1026
            ..|.:||.  :|:|..:|..|:|.. ..||. :.:|.|.|...||.:..:.::.|.:..|.|:..
 Worm   950 ALAGSFFLWNFAIAYMFGLWLISNNWTTPFA-VFQVIEALNMASMSVMMAASYFPEYVRARISAG 1013

  Fly  1027 RLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVA 1091
            .:|.::.:|.||.:     :....:..::...:..:|:.|.||.|....|||..::....|:|||
 Worm  1014 IMFTMIRQKAKIDN-----RGLTGETPDIRGDISMKGVYFAYPNRNRQLILNNFNMSAQFGETVA 1073

  Fly  1092 LVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENI 1156
            |||.|||||||.:||::||||...|.:.||..||: |:::..:|..:.:|.||||||..:|.|||
 Worm  1074 LVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIR-DISVKHLRHNIALVGQEPTLFNLTIRENI 1137

  Fly  1157 AYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKI 1221
            .||  ..:||..::..||..||.|||:.:||.||||.:||.|.:||||||||||||||:||||||
 Worm  1138 TYG--LENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASGGRLSGGQKQRIAIARAIVRNPKI 1200

  Fly  1222 LLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI 1286
            |||||||||||.:||::||:|||.|..||||:||||||||:||||.|.|.:||:.:|:|.|..|:
 Worm  1201 LLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLL 1265

  Fly  1287 SQGGIYAKLHKTQ 1299
            ::.|:|.:|.:.|
 Worm  1266 ARRGLYYRLVEKQ 1278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 456/1226 (37%)
ABC_membrane 108..354 CDD:279056 82/249 (33%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 127/236 (54%)
ABC_membrane 736..1006 CDD:279056 73/274 (27%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 132/239 (55%)
pgp-4NP_001257142.1 ABC_membrane 65..338 CDD:279056 88/302 (29%)
PTZ00265 68..1276 CDD:240339 461/1255 (37%)
ABC_MTABC3_MDL1_MDL2 389..625 CDD:213216 127/235 (54%)
ABC_membrane 724..993 CDD:279056 73/274 (27%)
ABC_MTABC3_MDL1_MDL2 1041..1278 CDD:213216 132/239 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 90 1.000 Domainoid score I4926
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm4744
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.930

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