DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and pgp-6

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001041287.2	Gene:	pgp-6 / 181278	WormBaseID:	WBGene00004000	Length:	1263	Species:	Caenorhabditis elegans

Alignment Length:	1302	Identity:	423/1302 - (32%)
Similarity:	693/1302 - (53%)	Gaps:	83/1302 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PMAEGLEPTEPIAFLK-LFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQF 83
            |.::..:|::..:|:: :|:.|:..|......|.:...:.....|.:...:.|.:.:||
Worm    14 PQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLV------ 72

  Fly    84 GTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGIL-LTIASVVMFISGIFSVDVFNMVAL 147
             |.:|..      ..||:..|..|:..|. |:..::..:. ..:.....||.......:...|..
Worm    73 -TITNAI------NNKTIDPADLEKAYEE-YERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGD 129

  Fly   148 RQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAI 212
            ....|:|.:..|.::::|..:.|..|..:.:..:.|::|:.|:..:||:...:..|..|.:..|:
Worm   130 NTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTAL 194

  Fly   213 SFSYGWKLT---------LAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIR 268
            :|...|:|.         :|.|.:|....::         |.|.::...||.||::|.:.|.:.:
Worm   195 AFYTDWRLASYGIFFSLGIAFSGFINSAGVM---------KTTGKQNTHYANAGSIAFQTLGAYK 250

  Fly   269 TVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAG----AFWYGVNLIID 329
            ||.|..|:|:|::||...|    ||.:..|....|..::.:.:.|..|..    ..:.|..:|..
Worm   251 TVCSLNGQKTEIERYTEEL----KAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYS 311

  Fly   330 DRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL---- 390
            . .:|.     |:::..|..::.||..::...|.:...|   |..::...:.::..|.|.:
Worm   312 G-TLET-----AVVVRLFHYMLFGAFCLSEALPHISRLA---GAISSTAPIAEMLIKDDNVIEKD 367

  Fly   391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQR 455
            .||.. :...:.|::.|::|.|.||:||:..|.:|::..::.|:.:||||:||.||||.||||..
Worm   368 ETDYD-VEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLH 431

  Fly   456 FYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQA 520
            :|:...|::.:|.:|:...||:.||..|.||.||||||..||.:||.:|.|..:..||..|..:|
Worm   432 YYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKA 496

  Fly   521 GAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQA 585
            .|::|:.:.|:..::::||||:||||||||||||||.|::|||||||||||||||.:||:.||:|
Worm   497 NAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKA 561

  Fly   586 LDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEV 650
            |:.||:|||||||:||||.||.|.||:.:..|:::|.|:||:|:|..|.|.::|:|      ..:
Worm   562 LENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA------QLL 620

  Fly   651 EKEDSIEDTKQKSLALFEKSFETSPLN---FEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKP 712
            |..|..|:.  ..||..:.|.|.|||:   .::...|.....:..::.::.:.:.:.|    :|.
Worm   621 ESHDDHEEL--PPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGA----KKS 679

  Fly   713 NFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSW 777
            |    ...|::..:.::|:|.:....:...|..||..|.:....|...| ...||.|..:.:.:.
Worm   680 N----LREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA-MIGEDMLYYSHLWAL 739

  Fly   778 ACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEA 842
            :.:.||....|..:.|.|.|......|:||:|..:|:.|::....::||.|:|...||.||:.::
Worm   740 SFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDS 804

  Fly   843 VDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREK 907
            .:::.|:...|..:|..:.....:::.|..|.||:.|..|...|::..:..........|:..:.
Worm   805 SNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAATETAIQEDT 869

  Fly   908 QVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFA 972
            ...|.:.|.|.|::.|:|||..|..|..::...:|.:|::.....::...:|..|....:...|.
Worm   870 IAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFV 934

  Fly   973 YAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPK 1037
            |:|:..:|..|....::...|...|..||...:.|...:.|:.|.:..|:.|...:|.:......
Worm   935 YSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPAT 999

  Fly  1038 IQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKST 1102
            :.......|..:.|...:.|.|     ||.|..|||..||||::|:|..|:|:||||.|||||||
Worm  1000 MPFSSSDGKKNIEKGEIIGENV-----QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKST 1059

  Fly  1103 CVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSM 1167
            .:.||:|:|...:|.:.||.:::: |:.|:.:|:.|.:||||||||..||.||:.|| ..|||..
Worm  1060 IISLLERFYHAVDGEVKIDSENVE-DINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LTRSVPQ 1122

  Fly  1168 VEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALD 1232
            :|:..|.::|||.:|:...|.|.||.:|.||.|||||||||||||||::||||:|||||||||||
Worm  1123 LELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALD 1187

  Fly  1233 LQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHK 1297
            ..||::||.|||||....:.:|:|||||||.|||.|.|::||:|.|||.|.:|:.:..||.:|.:
Worm  1188 SDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQ 1252

  Fly  1298 TQ 1299
            .|
Worm  1253 KQ 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	410/1230 (33%)
		ABC_membrane	108..354	CDD:279056	53/259 (20%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	122/236 (52%)
		ABC_membrane	736..1006	CDD:279056	63/269 (23%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	130/239 (54%)
pgp-6	NP_001041287.2	PTZ00265	32..1252	CDD:240339	419/1280 (33%)
		ABC_membrane	47..331	CDD:294371	64/316 (20%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	123/242 (51%)
		ABC_membrane	699..970	CDD:279056	63/271 (23%)
		ABC_MTABC3_MDL1_MDL2	1019..1254	CDD:213216	131/241 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930