DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and pgp-8

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_509811.2 Gene:pgp-8 / 181277 WormBaseID:WBGene00004002 Length:1243 Species:Caenorhabditis elegans


Alignment Length:1279 Identity:422/1279 - (32%)
Similarity:673/1279 - (52%) Gaps:97/1279 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 WLFFGFIMCCIKA----LTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASRE 107
            |..|.|::..:.|    ||.|.:...:.|.:...|........:|             |..:..|
 Worm    35 WEKFLFVIGVVSAICTGLTQPFMSYTFGEVSQAFVRITAAVNNAS-------------LDPSDLE 86

  Fly   108 ENNEALYDDS----ISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGW 168
            :..|..:.|.    |.:|:   :....||. |.....:|..:......|:|.|....::::|..:
 Worm    87 KAYEMFHADMNNVVIHFGL---VGCAFMFF-GFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKY 147

  Fly   169 HDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVIL 233
            .|..|....:..:.|::|:.|:..:||:...:.....|.|..|::|...|.|....|.:...:::
 Worm   148 FDTISTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSWTLASYGSVFAFGIVI 212

  Fly   234 LNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKG 298
            .....:....|...::...|:.||.:|.:.|.|.:||:|..|:..|:::|...|....|....:.
 Worm   213 SGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRA 277

  Fly   299 AF----SGLS----DAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGAD 355
            .|    .|||    :|:..::||:        |.:||.      ||......::..|..::..|.
 Worm   278 FFLATSRGLSHFFCNALNGTILYV--------GADLIY------NKTMNTVAIVTLFHYMLFSAF 328

  Fly   356 NIARTAPFLESFATARGCATNLFKVIDLTSKIDPL-------STDGKLLNYGLRGDVEFQDVFFR 413
            ::......:.....|...||.:|.|  |||..|.:       .||.   |..::|.:.|.:|.|.
 Worm   329 SLGEAFLHISYLLNAINSATPIFDV--LTSDDDMIENNQDNEQTDS---NKTIQGMLSFNNVKFA 388

  Fly   414 YPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQW 478
            |||||:|.:.||::..::.|:.:||||:||.||||.||||..||:...|::.:.|..:...|::.
 Worm   389 YPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQ 453

  Fly   479 LRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQ 543
            ||:.|.||.||||||..||.:||.:|.|.||..||..|..:|.|::|:.|:.:..::::||||:|
 Worm   454 LRNAIGVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNIKDGLKTIVGERGAQ 518

  Fly   544 LSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGA 608
            |||||||||||||.|::||.||||||||||||..||:.||.||..||:|||||:::||||.||..
 Worm   519 LSGGQKQRIAIARVLVKNPAILLLDEATSALDSASERAVQLALKKASEGRTTIIIAHRLSTIRHC 583

  Fly   609 DKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFET 673
            |||:.:.:||:.|.|||::|::::..|.|:|||       :.....|:|:......|  |:..:.
 Worm   584 DKIMVMSNGKIAEVGSHEELISMDREYSNLVRA-------QFFDSQSVEEDINGQGA--EEVIQK 639

  Fly   674 SPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTIS 738
            :|.|...|        || ::.|:|:|::..    ..|.|.:    .:|:..:.:...|.:..|.
 Worm   640 TPPNLNDG--------EP-LEELLKETSSDI----EIKSNIW----EVLRECRPDAFLLSMAVIG 687

  Fly   739 AVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWAC--LGLAFLTGLVCFLQTYLFNYAG 801
            :...|..:|..:.|..:.|.|.| .|.|:.|  |....||.  |.|..:..:..:.|.:.|....
 Worm   688 SAIQGCNFPILSQIIVQTYKAYA-MDGENIL--TYGHFWAAMFLVLGVIRPITLYCQFFFFGKVS 749

  Fly   802 IWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISS 866
            ..|:||:|..:|..:::....::||..:|...|..||:.:..:|:.|:...|..::.::.:|..:
 Worm   750 EKLSTRLRIKSFQHLLSLPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLA 814

  Fly   867 VSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLR 931
            :.:|.||:|||.|..:...|::..:..|..|..:.::..:....|.:.:||.|.:.|::||..|.
 Worm   815 ILIACYYSWKLTLQVVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVKALN 879

  Fly   932 READVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIK 996
            .||.||....|.:..::....::....|:.|......:...||::..:|..|:.:.::...|:..
 Worm   880 MEARVINLVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMDMYL 944

  Fly   997 VSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRY 1061
            ...||.|.|.|...::::.|.|..|:.:...:|.:......:.....|...::.|     ..|..
 Worm   945 SLITLSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSITK-----GEVNG 1004

  Fly  1062 RGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQ 1126
            ..::|.|..|||..:|:.::|:|..|:|:|:||.||.||||.:.||:.:|..|:|.|.||:|:::
 Worm  1005 ENVKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRADQGFIKIDNDNVE 1069

  Fly  1127 HDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYD 1191
             ::.||.:|:.||:|||.|.||..||.:||.|| ..|::|..||..|.:.|||.:|:..||.|.|
 Worm  1070 -NINLDHLRSNLGLVSQGPVLFNCSIRDNILYG-LTRNISQTEIENALQIANAFNFVFQLPQGLD 1132

  Fly  1192 TRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIA 1256
            |.:|.||.||||||||||||.||::||||:|||||||||||.:||::||.|||||....:.||:|
 Worm  1133 TIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVA 1197

  Fly  1257 HRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQK 1300
            |||||:.|||.|.|::||:|||||.|.||::..|.|.:|.:.||
 Worm  1198 HRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQK 1241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 410/1229 (33%)
ABC_membrane 108..354 CDD:279056 54/257 (21%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 123/236 (52%)
ABC_membrane 736..1006 CDD:279056 65/271 (24%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 127/239 (53%)
pgp-8NP_509811.2 PTZ00265 29..1241 CDD:240339 420/1277 (33%)
ABC_membrane 44..326 CDD:294371 63/312 (20%)
ABC_MTABC3_MDL1_MDL2 382..617 CDD:213216 124/241 (51%)
ABC_membrane 685..953 CDD:279056 65/270 (24%)
ABC_MTABC3_MDL1_MDL2 1005..1240 CDD:213216 126/236 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D216582at33208
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.790

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