DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and pgp-5

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001257116.1	Gene:	pgp-5 / 181276	WormBaseID:	WBGene00003999	Length:	1252	Species:	Caenorhabditis elegans

Alignment Length:	1297	Identity:	430/1297 - (33%)
Similarity:	677/1297 - (52%)	Gaps:	123/1297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 FIMCCIKALT-----LPAVVIIYSEFTSMLVD-RAMQFGTSSNVHALPLFGGGKTLTNASREENN 110
            ||...||..|     |..:.:::|..|.|... .:...|.:|.|           |...:...||
Worm    21 FIKVIIKCTTRYEKLLFFLGVVFSILTGMCQPFESYTLGETSQV-----------LVKVTNAINN 74

  Fly   111 EA-----------LYDDSISYGILL-TIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIR 163
            :.           |::..::..:|| .:.....|..|.....:...|.......:|.:..|.::|
Worm    75 KTIDPVDLAHAYKLFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLR 139

  Fly   164 QDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTL--AVSS 226
            :||.:.|..|..:.:..:.|::|:.|:..:||:...:.|:..|:|...::|...|:|..  .|.|
Worm   140 KDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFS 204

  Fly   227 Y-IPLVILLNYYVAKFQGKL--TAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLV 288
            : |.|..||:.:     ||:  ..::.|..:.||::|.:.|...:||.|..|::.||:||...|.
Worm   205 FGIVLSGLLDSW-----GKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELK 264

  Fly   289 PARKASQWKGAFSGLS--------DAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMI 345
            ...|.:..:.....||        :|:...:||        :|.|:|.:. .:|     |.:::.
Worm   265 NGEKYALNRAFVFSLSRSADYFFTNALNFVILY--------FGANMIYEG-TIE-----PGVVVR 315

  Fly   346 AFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTD---------GKLLNYGL 401
            ..:.|:.|:..:......:...|:|          |.||..|..:..|         .:.:....
Worm   316 ILYYILFGSYCLGEAILHISRLASA----------IPLTVPIADILLDSDATADEFFSEEIKDTF 370

  Fly   402 RGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLL 466
            :|.:.|::|.|.||:||:|.|.:.::..::.|:.:||||:||.||||.:|||..:|:...|.:.:
Worm   371 QGIISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISI 435

  Fly   467 DDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPE 531
            |..||...||:.||..:.||.||||||..:|.:||.:|||.||::||..|...|.|.:|:.|.|:
Worm   436 DGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPD 500

  Fly   532 SYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTI 596
            ..::::||||:||||||||||||||.|::||:||||||||||||.:||..||:||..||.|||||
Worm   501 GIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTI 565

  Fly   597 VVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQ 661
            ||:||||.||.|:||:.:..|:::|.|.|..|:|:.|.|.|:|:...::...|...|:....|:|
Worm   566 VVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEKMNENEERVTRQ 630

  Fly   662 KSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAK 726
            .|    ...|.::.::.:|     :..|:..:|.||.:...:.|    :|.|    ...|::..:
Worm   631 SS----HSDFPSNEISHQK-----IDQEDDYVKKLIAEIKEEGA----KKSN----ICEIIKYCR 678

  Fly   727 QEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCF 791
            .|:|.|.:..:.:...|..||..:.:..:.|.|.| .|.::.|.::...:.:.|.|||...:..|
Worm   679 SEYCILFIAVLGSAIQGIYYPLSSQLMIKSYEAYA-FDKDEMLSKSHFWALSILFLAFTRPIFIF 742

  Fly   792 LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGM 856
            .|.|.|......|:.::|:|:|..:::....::||..::...||.||:.::.::..|:...|..:
Worm   743 FQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSV 807

  Fly   857 IQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESI 921
            |..|...:.:|.::.:|:||::|..|..||::..:.......:..||..:....|::.|.|.|::
Worm   808 IMTLVAILLAVIMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEAL 872

  Fly   922 TNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASA----FFAYAVALCYGGV 982
            .|:|||..|..|..||...|..:|:    ||.....|.|:..|....|    ||.|||:..:|..
Worm   873 ENVRTVRALNMENRVILLVTSHLQK----IRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTW 933

  Fly   983 LVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI---QSPMG- 1043
            ||...::...|...|..||...:.....::|:.|....|:.|...:|.:. ..|.|   .|..|
Worm   934 LVLREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDSSQGK 997

  Fly  1044 -TIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLL 1107
             .|||         ..:..:.:.|.|..|.|..||:|:.|::..|:|:||||.||.||||.:.||
Worm   998 RNIKN---------GEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLL 1053

  Fly  1108 QRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIA 1172
            :|:|...:|.:.||.:::. |:.|..:|..:.:|||||.||..||.||..:|.: .:.|.:||..
Worm  1054 ERFYHAVDGEVKIDEENVV-DVNLHHLRESVSLVSQEPVLFNCSIKENFLFGIS-HNASQLEIDQ 1116

  Fly  1173 AAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQ 1237
            |.|.|||.||:...|.|.||.:|.||.|||||||||||||||::||||:|||||||||||..||:
Worm  1117 ALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEK 1181

  Fly  1238 LVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            :||.|||||....:.:|:|||||||.|||.|.|::||:|.|||.|.:|:.:..||.:|.:.|
Worm  1182 VVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	418/1252 (33%)
		ABC_membrane	108..354	CDD:279056	60/270 (22%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	123/236 (52%)
		ABC_membrane	736..1006	CDD:279056	72/273 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	122/239 (51%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	426/1287 (33%)
		ABC_membrane	41..322	CDD:294371	67/310 (22%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	123/236 (52%)
		ABC_membrane	688..955	CDD:294371	72/271 (27%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	122/239 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930