DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and pgp-10

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_509205.2 Gene:pgp-10 / 180981 WormBaseID:WBGene00004004 Length:1382 Species:Caenorhabditis elegans


Alignment Length:1401 Identity:413/1401 - (29%)
Similarity:688/1401 - (49%) Gaps:187/1401 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIY 69
            :|:......||.:..|.....||     :.:|:.|:...::..:..|.....:::...|.|.:|.
 Worm    59 DVTMDDPLDKSSDSKPKLGFFEP-----YKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIM 118

  Fly    70 SEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYG-----ILLTIASV 129
            ..|.|:.:.|  :.|..          |.|.||       ::...||..::.     |.:...|:
 Worm   119 GNFVSISILR--EEGKL----------GLKNLT-------SDYPIDDQFAHSATPAFISMLGLSI 164

  Fly   130 VMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISE 194
            .|||:.......:.:.::|||.|::......::..||.|.:.....:....:.:..:.|.:|||:
 Worm   165 AMFIAAFCQRIAWEISSIRQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQESADSIYNGISD 229

  Fly   195 KVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNL 259
            .:...|:::...::.:.:.....|.:||.:...|||:|:.....:|:.......|.:......||
 Worm   230 HLPMVVFILSYLLVNIGVCLYIQWDVTLFMCLAIPLLIISRILYSKWFANTMEEETKLQNKITNL 294

  Fly   260 AEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWK----GAFSGLSDAVLKSMLYLSCAGAF 320
            ..|..:.|.||:||..:|.::.::|.......|.::.:    ..|..|:..:|..:::   .||.
 Worm   295 VNETFNCITTVISFAAQKQKINKFEKLSAEHSKLTEERLRSSVVFDSLTQILLTELIF---TGAL 356

  Fly   321 WYGVNLIIDDRNVENKEYTPAI--LMIAFFGIIVGADNIARTAPFLESFAT-ARGCATNLFKVID 382
            .||:..:.|  |...:....||  |.:....|.:|         |..:.|| |:..|..:.:|::
 Worm   357 CYGIWRVAD--NSPGRLCALAINMLYMCVTSISIG---------FHMNGATRAKDNAKEICEVLN 410

  Fly   383 LTSKIDP--LSTDGKL--------------LNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIR 431
            ...||:.  .|.|..:              :.:..:|.:.|:|:.|.||||.|..|.||::.::.
 Worm   411 EQPKIEVELASIDNNIDYVPVTRCKYRRQSMKFMGKGALHFRDIHFSYPSRKETEVLRGISFKVE 475

  Fly   432 AGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGT 496
            ||:.:|:|||||.||||...||.|||||..|::|||..:|:......||...::|.||||||.||
 Worm   476 AGEKIAIVGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGT 540

  Fly   497 IAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQN 561
            |:.||.||:..|||:||..||.:.||.:||.:||:..::.:||||.|||||||||:|||||:|:.
 Worm   541 ISDNIRYGRLDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRK 605

  Fly   562 PKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHD 626
            |.:|:.||||||||...|::|..|:||||:|.|||.::||||.|:.:|:|:.:|:||::|||..|
 Worm   606 PIVLIFDEATSALDNIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPD 670

  Fly   627 DLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQK------- 683
            :|:| ..|.::.|.  .|..:....::...:...:.|..:|.::...:.|.|.:..|:       
 Worm   671 ELIADANGIFHKMY--NDQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARS 733

  Fly   684 --------------NSVQFEEPIIKALIK----------------------DTNAQSAEAPPEKP 712
                          ||::.|:..:..:.|                      |:.....:.|.::.
 Worm   734 SLGGNKKLGKSYSVNSMEKEKLKLPVMSKKKSERLDYKYSKVHSMDVKQHTDSMHDDDDLPGKET 798

  Fly   713 NFFRTFSRILQLAKQEWCYLILGTISAV---AVGFLYPAFAVIFGEFYAALAE----KDPEDALR 770
            ||  |..:.|..:.:....|:.|.|...   ||.:|...|.|      |::.|    .|.|.||:
 Worm   799 NF--TVLKDLIYSYRTGLPLLAGAIPTTIVRAVFYLLICFQV------ASVLEISIAPDEERALQ 855

  Fly   771 RTAVLSWACLGLAFLTGLV-----------CFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWF 824
            ...|       .|..|.|:           .|:..|     |......||...|..::.....:|
 Worm   856 IFIV-------AAIYTALIIVKTIFEALGRIFIALY-----GHGFCKFMRNEMFRKVLRHGAAYF 908

  Fly   825 DDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV 889
            |:|.||.|.|..::..|:..:...:...|..:|..:...:.|:..|::.|||:||||....|...
 Worm   909 DEERNSPGRLVHKVINESSTLNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLCSFQFPAYF 973

  Fly   890 GSVILEAKMMSNAVVREKQVIEE---ACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLI 951
            ...||:.:   ....|::|:::|   |..:|:..:.|:.|:.....::.....:.:.::.|...:
 Worm   974 VIRILQIR---EGTKRQRQMVDEEKKAANLASVVLANMSTIKAYNLQSHFYNVFCDALKPVSQCM 1035

  Fly   952 RQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTP 1016
            :::.....::.:...:..:...|:.|.:|.|::...::...|.::|.....:|:...:|.:|...
 Worm  1036 QKQSLISALVFACQYSFTYILIAITLHFGKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVS 1100

  Fly  1017 AFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVR--------YRGIQFRYPTRPD 1073
            .|:.|.||...:.::: |:|.:.      .:.|::     ||:|        .:.:.||||:||.
 Worm  1101 DFTKAQIAAENVMRVI-REPPVD------MDNLSE-----EGLRPKLEGNLCLKDVSFRYPSRPI 1153

  Fly  1074 AKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKL 1138
            ..:|..|:|:|..|:::||||.||.|||:.:.|.||.|:..:|.:.||..:|: .:....:|..:
 Worm  1154 VPVLTNLNLKVRGGESIALVGPSGSGKSSVISLFQRMYNATDGVVIIDKYNIK-SINPAYLRRCI 1217

  Fly  1139 GIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSG 1203
            ..|.|||.||..:|.||||:|......::.::|.|||.|:.|:||.|||.||||.:|..|.||||
 Worm  1218 VQVGQEPDLFSFTIKENIAFGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGEFGAQLSG 1282

  Fly  1204 GQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALD-------TACSGRTCIVIAHRLST 1261
            |||||||||||::|.|.:|||||||||||..||:.||.|.:       |.|   |||.|||||||
 Worm  1283 GQKQRIAIARAIIRKPTVLLLDEATSALDSASEREVQNAFERVKRSTKTQC---TCIQIAHRLST 1344

  Fly  1262 VQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHK 1297
            ::|.|.|.||.:|::.|:|:|.|||:..|||.::::
 Worm  1345 IRNVDKIYVIVHGEIAEEGSHEQLINLKGIYYEMNQ 1380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 397/1315 (30%)
ABC_membrane 108..354 CDD:279056 52/256 (20%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 122/237 (51%)
ABC_membrane 736..1006 CDD:279056 59/290 (20%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 119/254 (47%)
pgp-10NP_509205.2 MdlB 73..687 CDD:224055 203/653 (31%)
ABC_membrane 156..381 CDD:294371 49/229 (21%)
ABC_MTABC3_MDL1_MDL2 450..687 CDD:213216 122/238 (51%)
ABC_membrane 823..1099 CDD:294371 60/296 (20%)
MdlB 825..1382 CDD:224055 188/593 (32%)
P-loop_NTPase 1141..1381 CDD:304359 118/244 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24221
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
87.980

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