Protein Alignment Mdr65 and mrp-6

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001362008.1
• Gene: mrp-6 / 180691
• WormBaseID: WBGene00003412
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1377
• Identity: 299/1377 - (21%)
• Similarity: 526/1377 - (38%)
• Gaps: 368/1377 - (26%)

  Fly    42 YGEIGWLFFGFIMCCIKA-LTLPAVVIIYSEFTSMLVDRAMQFGTS------------------- 86
            |..|.|..|||  ||:.. |.:.|:|       |..|..:.|.|.:
 Worm   253 YAYILWSMFGF--CCLLGFLVMMAIV-------SFQVHYSYQLGVNRRNIGDKMDSRLKVMSEII 308

  Fly    87 SNVHALPLFGGGKTLT---NASREENNEAL----YDDSISYGILLTIASVVMFISGIFSVDVFNM 144
            :.:..:.:.|......   ...||:..:|:    :..|:..||....|.:.:|:. ||:.|.|:.
 Worm   309 NGIKVIKMHGWENAFAEKIRILREDEIKAVGTSAFYSSMVMGIYFISAKIGLFVY-IFACDYFDE 372

  Fly   145 VALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIIT 209
            :...:.......||:||                                 ::...::|.:|.:
 Worm   373 ILTTRGVFASSALFNSV---------------------------------RLPFALFLPLGLL-- 402

  Fly   210 VAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFG 274
                  :|.:| .:.|..|.|...|..| ::...:|.:.:.|.
 Worm   403 ------FGREL-FSTSRRIDLFFCLEEY-SRITLELDSTDTED---------------------- 437

  Fly   275 GEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYT 339
            |.|:|.:.     :..:|..: |.:::...|...|:.::|:...|.||..    |:.:.:.|:..
 Worm   438 GSKNEKEG-----LTLKKIGE-KPSWTLKCDKAEKTSVFLNKVTAVWYDK----DEHDQKKKKKN 492

  Fly   340 PAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGD 404
            ...|          :||.|                    .||....|.:||.     :.|.:
 Worm   493 FKAL----------SDNDA--------------------TVIAGEKKDEPLH-----VVYAV--- 519

  Fly   405 VEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDL 469
               ||:.|.:.                ||....::||.|.|||               |:||..|
 Worm   520 ---QDLSFEFV----------------AGTCYGIIGSVGSGKS---------------SLLLTIL 550

  Fly   470 DIRKYNIQWLRSNIAVVG------QEPVLFLGTIAQNISYGKPGATQK---EIEAAATQAGAHEF 525
            .    ..:..|.|::|.|      |||.:|.|:|..||.:|.....::   .:|.........:|
 Worm   551 S----ESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYENALELCLLTPDLRQF 611

  Fly   526 ITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLAS 590
                .....:::|:.||.|||||:.|:|:|||:..:..|.|||:..||:|....|::.:.|   .
 Worm   612 ----ANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKKLYENL---I 669

  Fly   591 KG----RTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVE 651
            :|    :..|:|:|::..:...|.::.:.:.|::..||.|:|.:              ...|:..
 Worm   670 RGFLSDKLVILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKS--------------TFTDDFI 720

  Fly   652 KEDSIEDTKQKSLALF----EKSFETSPLNFEKGQK----------NSV-----QFEEPIIKALI 697
            |..::| |:.:|..||    ..|...||:|.|..:|          |||     ..|...:|.::
 Worm   721 KLQAVE-TEVQSDELFVDGPPSSPPPSPVNIESMEKINKESIFQRANSVLSGSKMSETEYVKEIV 784

  Fly   698 KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVI------FGEF 756
            .::....            |.|..:.     |.| ..|.|:.:..|.......:|      |.::
 Worm   785 YESRKSG------------TISWSVY-----WEY-TRGVINPLKYGIWLVVCVLITQLMNNFVDW 831

  Fly   757 YAA--LAEKD---------PEDALRRTAVLSWACLGLAFLT-GLVCFLQTYLFNYAG----IW-- 803
            :..  |.:.|         .|:..|...||.:. ..:.|.| .|...:.|.:.:..|    :|
 Worm   832 WLNKWLVDLDMNNADNSTSKEEFNRNVDVLGYT-FNVTFQTYELTFIISTVIMSILGVVRSVWFR 895

  Fly   804 ----LTTR-MRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNF 863
                :.:| :....|:.::..|..:||  .||.|.:..|.|.:       ||  |:..:.|.:.|
 Worm   896 NAQLMASRILHNSMFDCVLKTESEFFD--KNSEGMILNRFSKD-------IG--LTDDLLAFTYF 949

  Fly   864 ------ISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACR-----IA 917
                  ::.|.:....:....::.|| |..|........||..:. .||.:.||.|.|     ..
 Worm   950 EFVFGTLTFVGIVGLVSMVRPIVILA-CAFITAGFYFCRKMYVHR-SRELKRIEAAARSPLNTTI 1012

  Fly   918 TESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKL---RWRGVLNSTMQASAF---FAYAVA 976
            |.::..:.|:...|:|.::|.::..............|   ||.|:....: .|.|   .|..|.
 Worm  1013 TSTVHGLSTIRAYRKENEMIEKFCALHDVYMAAYNMGLLSARWFGICIDFL-VSVFVSIVAIVVV 1076

  Fly   977 LCY--------GGVLVSEGQLP--FQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQI 1031
            |.|        |..||...||.  |..|::.|..|..|.:.:.:.|.:|.
 Worm  1077 LQYETLTVGEVGLCLVCAVQLSGFFSWIMRQSAELENGMVSVERVLEYTK--------------- 1126

  Fly  1032 LDRKPKIQSPMGTIKNTLAKQ-LNLF--EG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVAL 1092
            |..:.:.:.|....   |.|| ||.:  :| :.:..:...|   .:.|:|..|...||.||.:.:
 Worm  1127 LKSEEEARRPHDAY---LDKQLLNSWPTKGEIEFENVSVNY---GETKVLKNLSFVVLGGQKIGV 1185

  Fly  1093 VGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIA 1157
            ||.:|.||||.::::....:...|.:.||..|:.| ::|:..|..:.|:.|||.:|..::.||:.
 Worm  1186 VGRTGAGKSTLIKIIFGLKEYCSGRVTIDGVDLDH-ISLNFRRGGMSIIPQEPVIFSGTVRENLD 1249

  Fly  1158 YGDNRRSVSM---VEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNP 1219
            ..|.....::   :|.....:|       |:...|.:..:|.||..||.||:|...:|||::...
 Worm  1250 PFDEYDDATIWFALEQCELKRS-------ITKEKGLNVELGQRGVSLSVGQRQLFCLARAMIHRS 1307

  Fly  1220 KILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQ 1284
            |||::||||:.:|..::..:|:.:.......|.|.:||||.|:.|:|.:.|.:.|::||....:.
 Worm  1308 KILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGELVEFDKPIT 1372

  Fly  1285 LI-SQGGIYAKL 1295
            |: .|..:::::
 Worm  1373 LLDDQSSLFSRM 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	284/1308 (22%)
		ABC_membrane	108..354	CDD:279056	39/249 (16%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	62/249 (25%)
		ABC_membrane	736..1006	CDD:279056	69/325 (21%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	69/241 (29%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	299/1377 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000