DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and haf-3

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	638	Identity:	207/638 - (32%)
Similarity:	333/638 - (52%)	Gaps:	54/638 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   692 IIKALIKDTNAQSAEAPPE----KPNFFRTFSRILQLA-KQEWCYLI----LGTISAVAVGFLYP 747
            :||:.....|....|...|    |...::....||.|| ..:|..::    ||..|::   ||:.
Worm    43 LIKSKQAFRNVSVVETKRESYKLKNASWKDLKAILSLAGPYKWRIMLGISFLGISSSI---FLFT 104

  Fly   748 --AFAVIFGEFYAALAEK-DPED-ALRRTAVLSWACLGLA--FLTGLVCF-LQTYLFNYAGIWLT 805
              ....:..|:.....:| ||.| ||..........:.||  |:.|.:.. .:.|..:.||..:.
Worm   105 PRVLGKLIDEWDETKQDKMDPNDKALLLARFFKENPIALAGVFMLGAIAIAARIYCMHTAGQLVI 169

  Fly   806 TRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVA 870
            ..:|...||:::.|::.:||  .|.||.:.:|||.:|:.:..::...||...:||.....|..:.
Worm   170 NDLRKSVFNSVLRQDMAFFD--KNKVGEIVSRLSTDALIVGYSVSMNLSDGARALITCFGSGGLM 232

  Fly   871 MYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREAD 935
            :|.:..:..:.....|:|||:..:..|:.....:..::.:..|.::|||.::::|||..|..|..
Worm   233 VYTSLAMCKVIFVVVPVIVGTFAVFGKLQRKYTLMMQEAVAGANQVATERLSSVRTVRMLVAERK 297

  Fly   936 VIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSET 1000
            .:..|:::|..:..:.:::...:|.:..:.|.:.:.|.:..|.||..|:|:|.|.:.::   |..
Worm   298 ELAAYSDKINEIWQISKKEGLAKGFMFGSFQFTGYLALSSILFYGSNLISQGLLTYGEL---SSF 359

  Fly  1001 LLYGSMMLAQSLAFTPAFSAALIAG----HRLFQILDRKPKIQSPM------GTIKNTLAKQLNL 1055
            .|| :::.|.||:....|...|:.|    .|||::.:|:|:|  |:      |.:|:|
Worm   360 CLY-AVLSAGSLSAMSGFYLELMKGLGASSRLFELKNREPRI--PLEGGVQIGNVKDT------- 414

  Fly  1056 FEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHI 1120
               :|:..:.|.|..|.  .:.:.:..:|..|:..|:||.||.||||...||.|.|||..|.|.:
Worm   415 ---IRFEHVAFGYADRD--PLFHNISFDVPAGKITAVVGSSGSGKSTIASLLLRLYDPTSGRILV 474

  Fly  1121 DHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGD-NRRSVSMVEIIAAAKSANAHSFII 1184
            |..|:: |:.....|..:|.|.|||.||..:|.|||.||. ...:|:..||::||..:||..||.
Worm   475 DGTDLK-DIDPSYWRRHIGTVGQEPVLFSTTIKENIIYGSLEPENVTDAEIVSAADQSNADEFIS 538

  Fly  1185 SLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALD--TAC 1247
            ..|..|||::|..|:.||||||||||||||||..|.||::||||||||..||.||:.||:  .|.
Worm   539 RFPIKYDTKVGEHGSTLSGGQKQRIAIARALVNKPNILIMDEATSALDASSEYLVRIALNKLLAN 603

  Fly  1248 SGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKLHKTQ 1299
            |.:|.::|||||||:::||.|.|:..|.|.|.|::.:||: ..||:.||.:.|
Worm   604 SKQTVMIIAHRLSTIKHADQIVVVDRGSVAESGSYDELIAIPDGIFRKLVEKQ 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	207/638 (32%)
		ABC_membrane	108..354	CDD:279056
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216
		ABC_membrane	736..1006	CDD:279056	65/276 (24%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	112/243 (46%)
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	201/611 (33%)
		ABC_membrane	96..366	CDD:279056	65/278 (23%)
		P-loop_NTPase	415..656	CDD:304359	112/243 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910