Protein Alignment Mdr65 and haf-1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_503098.2
• Gene: haf-1 / 178522
• WormBaseID: WBGene00001811
• Length: 677
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 167/590 - (28%)
• Similarity: 297/590 - (50%)
• Gaps: 47/590 - (7%)

  Fly   721 ILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGE-----------------FYAALAEKDPEDA 768
            :.::||....::.|||...|....::.....|.|:                 |...:|:...|..
 Worm    74 LYEIAKPFRKWIFLGTSFMVVSSGIFLIIPRILGKLIDQFDSNTGVQKAEEVFTMKIAKYFKEQP 138

  Fly   769 LRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGA 833
            :        :.:||..:..|....:.|....||:.:...:|.|.:::::.|::.:||  .|.||.
 Worm   139 M--------SLVGLLAIGALATAAKVYCLQIAGVNIVGSLRKMVYSSIIRQDMTFFD--KNMVGE 193

  Fly   834 LSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKM 898
            :.:|.:.:.|.:..::...|...::|:...:.|:.:.:..:.:|:.:.....||::|...:..::
 Worm   194 IGSRHAADTVIVGYSVSSSLRAGVRAVLVGVGSIGMMLMTSLELSTVSFLTAPIVMGIFKMFGRV 258

  Fly   899 MSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNS 963
            ......:.::|..:..:.|.|.:.|::|:..|..|...|.||.::.:.|..:.:.:...:|.|..
 Worm   259 QQQCTWQLQEVAADVNQTAIERMANMKTIRMLSAEQQSIDEYCKKGELVLDISKTEALAKGSLIG 323

  Fly   964 TMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAF----SAALIA 1024
            :.|.:.:.|::..|.||..|::.|.:.:.::   |...|| :::.|.||:....|    ...|.|
 Worm   324 SFQFTGYSAFSSILFYGSHLINTGHITYGEL---SSFCLY-AVLAAASLSNISGFYNEVMKGLGA 384

  Fly  1025 GHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQT 1089
            ..||.::.:.:|.:....| ||.|     ::...:::..:.|.|..|  .|.|..:..::.:|:.
 Worm   385 SSRLLELKNAQPIMNLNSG-IKKT-----DITTSIQFENVSFAYAGR--KKTLENISFDIPRGKI 441

  Fly  1090 VALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAE 1154
            .|::|.||.|||:...|:.|.|||.:|.:.:|..|:: ||.....|..:|.|.|||.||..||.|
 Worm   442 TAVIGPSGSGKSSIANLMLRLYDPADGRVTVDGVDLR-DLNATTWRHAIGTVGQEPVLFTCSIRE 505

  Fly  1155 NIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRN 1218
            ||..| ::...||..|:..||:.|||..||....||::|.:|..|.:|||||||||||||||:..
 Worm   506 NILMGTEHPEKVSQYELEEAAQLANALDFIQGFENGFETMVGEHGCKLSGGQKQRIAIARALISK 570

  Fly  1219 PKILLLDEATSALDLQSEQLVQQALDTACSGR--TCIVIAHRLSTVQNADVICVIQNGQVVEQGN 1281
            |||::|||||||||..|:.|::..||......  |.:||||||:|:|.||.:..:..|::..||.
 Worm   571 PKIMILDEATSALDATSDYLIRMTLDNLLKNHNLTVLVIAHRLATMQQADQVVYVNRGRIEGQGT 635

  Fly  1282 HMQLI 1286
            ..:::
 Worm   636 FDEMM 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	167/590 (28%)
haf-1	NP_503098.2	MdlB	67..641	CDD:440747	167/590 (28%)