Protein Alignment Mdr65 and haf-9

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_491754.1
• Gene: haf-9 / 172288
• WormBaseID: WBGene00001819
• Length: 815
• Species: Caenorhabditis elegans
• Alignment Length: 673
• Identity: 218/673 - (32%)
• Similarity: 333/673 - (49%)
• Gaps: 105/673 - (15%)

  Fly    16 QEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRA 80
            ||||..|.....|    |..|||...|....|.::|.....:...:|..|.|.|  :|
 Worm   175 QEEAEKAAEQRET----FQLLFRLLGYMGRQWKYYGMAFFFLFCYSLSRVFIPY--YT------- 226

  Fly    81 MQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSV--DVFN 143
                             |:.:|         |::.|..||..|    ...:||.|:.|:  .||.
 Worm   227 -----------------GEVVT---------AVFGDKASYEKL----HKTVFIMGMLSLASTVFG 261

  Fly   144 MVALRQVT--------RMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFV 200
            .:.....|        ::|..||.||::|:||:.|:.........:..|.:.:.:.:|      :
 Worm   262 GLRGGSFTYAHATIDRQIRNDLFRSVVKQEIGFFDMNKTGEICSRLSADCQTMSNTLS------L 320

  Fly   201 YLVV---------GFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGA 256
            |:.|         |.:|   ..|:..|||::.....||::.|:|.....:...|:...|.|.|.|
 Worm   321 YMNVLTRNLTMLFGSLI---FMFTLSWKLSMITLINIPIIFLVNKIFGVWYDMLSEETQNSVAKA 382

  Fly   257 GNLAEEILSSIRTVVSFGGEKSEVQRYENFL-----VPARKASQ-----WKGAFSGLSDAVLKSM 311
            .::|||:|||||||.||..|..|..|:..||     :..||...     |....  |...:|..:
 Worm   383 NDVAEEVLSSIRTVKSFACENYESSRFMTFLNVTLKIATRKVFVVIGLIWSNEL--LQMGILTIV 445

  Fly   312 LYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATN 376
            |        |||.:|:|     |||..:..::....:...:| :|:............|.|.:..
 Worm   446 L--------WYGGHLVI-----ENKVESGLLVSFLLYQFQLG-ENLRELGEVWNGLMQAVGASRK 496

  Fly   377 LFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGS 441
            :|:.||...:::   ..|.....|:.|.:||:.|.|.||.||::.:...|...:..|:.|||||.
 Worm   497 VFEFIDRPPRVE---NTGTYAPDGMTGKIEFRHVAFSYPIRPDLPIMEDLTFTVEPGEVVALVGP 558

  Fly   442 SGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKP 506
            ||.|||:|:.:|:.||:|..|.||:|.:.:|:|:.::|.:.:|:|||||||:..::.:||.||..
 Worm   559 SGGGKSSCIAMLEHFYEPTSGEVLIDGVPVREYDHKFLHTKVALVGQEPVLYARSVTENIGYGLD 623

  Fly   507 GATQKEIEAAATQAGAHEFITN-LPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
            ......::.:|..|.||.||.| ..:.|.:.:||:|||:||||||||||||||::.|.:||||||
 Worm   624 KYDDDMVQNSAKLANAHTFIMNDTTDGYNTNVGEKGSQMSGGQKQRIAIARALVRQPVVLLLDEA 688

  Fly   571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAY 635
            |||||.:||..||:|:....||:|.|:::||||.:..|||||.|:.|||.:.|:|..||..||.|
 Worm   689 TSALDAESEHTVQEAISKNLKGKTVILIAHRLSTVENADKIVVINKGKVEQLGNHKTLMEQEGLY 753

  Fly   636 YNMVR----AGDINMPDEVEKED 654
            ..:|:    :|:..:.||:|:.:
 Worm   754 KQLVQRQMMSGEDGLDDEIEEPE 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	192/556 (35%)
		MdlB	711..1299	CDD:440747
haf-9	NP_491754.1	3a01208	19..757	CDD:273363	213/652 (33%)