DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and haf-6

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_490828.3	Gene:	haf-6 / 171694	WormBaseID:	WBGene00001816	Length:	668	Species:	Caenorhabditis elegans

Alignment Length:	635	Identity:	216/635 - (34%)
Similarity:	320/635 - (50%)	Gaps:	80/635 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TYGEI--------GWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGG 97
            |.||:        || ||..::|.|    |.|.:.|                      .:||..|
Worm    83 TAGELWNLIKPFFGW-FFAAVVCAI----LSAYINI----------------------QIPLCLG 120

  Fly    98 GKTLTNA-----SREENN-----EALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTR 152
              .|.|.     ..|.||     |.|...::....|....|.:.|:    .:....::..|..|:
Worm   121 --DLVNGIVKIIKDESNNLRSHFEQLKPSALHLMTLYVAQSALTFL----YITFLTVLGERMATK 179

  Fly   153 MRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDG----ISEKVGHFVYLV--VGFIITVA 211
            ||..||..::..|:.:.|.......:..:..||::.:..    :|:.:..|...:  :|.:..::
Worm   180 MRSDLFQKLLHHDMAFFDSHKSGELSARLNADVQEFKSSFKLCVSQGLRTFAQTIGCIGSLYFLS 244

  Fly   212 ISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGE 276
            .:      :|:...:.:|.:||....:.....:|:.|.|...|.|..:::|.|::|||:.:|..|
Worm   245 PT------MTMYTVAVVPGIILAGSAIGAGLRQLSRRAQGQSATASAVSDEALTNIRTIRAFAME 303

  Fly   277 KSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPA 341
            |.|.:.::|.|..||...:..|...||..|.....|........:.|.|||      ...|.||.
Worm   304 KLESRLFDNELDKARAMQEQLGVGIGLFQAGTNLFLNGMILSVLYGGSNLI------SKGEMTPG 362

  Fly   342 ILMIAFFGIIVGADNIARTAPFLE-SFATARGCATNLFKVIDLTSKID---PLSTDGKLLNYGLR 402
            .||    ..:|.|..|.|:...|. .|.||....|...:|:.. |:::   |:.|...:..:.|.
Worm   363 ALM----SFLVSAQTIQRSLSQLSIIFGTAIKGWTAGGRVLQF-SRLEPSIPMDTGVCIPYHSLW 422

  Fly   403 GDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLD 467
            ||::|:||.|.||:||...|...|.:.|.|||.|||.|.||.||||...||:|||:|..|.|.||
Worm   423 GDIKFEDVSFSYPTRPGHTVFENLTLSIPAGQVVALCGPSGEGKSTITHLLERFYEPKSGRVTLD 487

  Fly   468 DLDIRKYNIQWLRSN-IAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPE 531
            ..|:|:.|::|||.. |.::.||||||..::.:||.||:|.||.:|:..||..|...||::..|.
Worm   488 GRDLRELNVEWLRGQVIGLISQEPVLFATSVEENIRYGRPDATDEEVREAARAAHVDEFVSRFPS 552

  Fly   532 SYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTI 596
            .|.:::||||:|||||||||||||||:::||.||:|||||||||..||..||:||:...||||.:
Worm   553 GYSTVVGERGAQLSGGQKQRIAIARAILKNPPILILDEATSALDSHSEHMVQEALNNVMKGRTVL 617

  Fly   597 VVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYY-NMVRAGDIN 645
            :::||||.||.|..|..|.|.|.||.|:|:.|||.:|:.| .:|.|.:::
Worm   618 IIAHRLSTIRSAQMIYVIKDKKALESGTHEQLMAKKGSLYRKLVEAHNVD 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	204/577 (35%)
		ABC_membrane	108..354	CDD:279056	57/256 (22%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	125/238 (53%)
		ABC_membrane	736..1006	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216
haf-6	NP_490828.3	MdlB	87..663	CDD:224055	212/625 (34%)
		ABC_membrane	102..378	CDD:279056	71/323 (22%)
		ABC_MTABC3_MDL1_MDL2	425..663	CDD:213216	125/237 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910