DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and Abcb1a

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_596892.1 Gene:Abcb1a / 170913 RGDID:619951 Length:1272 Species:Rattus norvegicus


Alignment Length:1310 Identity:546/1310 - (41%)
Similarity:795/1310 - (60%) Gaps:79/1310 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWL-----FFGFIMCCIKALTLPAVVIIY 69
            |..||..::    |..|....::.|.:||::     |||     ..|.:...|..:.||.:::::
  Rat    16 SKMGKKSKK----EKKEKKPAVSVLTMFRYA-----GWLDRFYMLLGTLAAIIHGIALPLMMLVF 71

  Fly    70 SEFTSMLV----DRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVV 130
            .:.|....    :|:|.|..:::::|           ....|....|.|...|..|:|     :|
  Rat    72 GDMTDSFANVGNNRSMSFYNATDIYA-----------KLEDEMTTYAYYYTGIGAGVL-----IV 120

  Fly   131 MFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEK 195
            .:|    .|.::.:.|.||:.::|.|.|.:::.|:|||.|:.........:.|||.||.:||.:|
  Rat   121 AYI----QVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDK 181

  Fly   196 VGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLA 260
            :|.|...:..|.....|.|:.||||||.:.:..|::.|.....||.....|.:|.::||.||.:|
  Rat   182 IGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVA 246

  Fly   261 EEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVN 325
            ||:|::||||::|||:|.|::||.|.|..|::....|...:.:|......::|.|.|.|||||.:
  Rat   247 EEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTS 311

  Fly   326 LIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
            |:|      :||||...::..||.:::||.::.:.:|.:|:||.|||.|..:|.:||....||..
  Rat   312 LVI------SKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSF 370

  Fly   391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQR 455
            |..|...: .::|::||:::.|.||||.:|.:.:|||:::::||||||||:|||||||.||||||
  Rat   371 SKSGHKPD-NIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQR 434

  Fly   456 FYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQA 520
            .|||:.|.|.:|..|||..|:::||..|.||.||||||..|||:||.||:...|..|||.|..:|
  Rat   435 LYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA 499

  Fly   521 GAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQA 585
            .|::||..||..:.:::||||:||||||||||||||||::|||||||||||||||.:||..||.|
  Rat   500 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 564

  Fly   586 LDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAG-DINM 646
            ||.|.:||||||::||||.:|.||.|.....|.::|:|:||:||..:|.|:.:|   .|| :|.:
  Rat   565 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIEL 629

  Fly   647 PDEV-EKEDSIED----TKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAE 706
            .:|. |.:|.|::    :|....:|..:......:.....|...:..:|           |...:
  Rat   630 GNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKE-----------ALDDD 683

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKD-PEDALR 770
            .||      .:|.|||:|...||.|.::|...|:..|.|.|||::||.:......:.| ||...:
  Rat   684 VPP------ASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQ 742

  Fly   771 RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALS 835
            .:.:.|...|.|..::.:..|||.:.|..||..||.|:|.|.|.:|:.|::.||||..|:.|||:
  Rat   743 NSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALT 807

  Fly   836 ARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMS 900
            .||:.:|..::||.|..|:.:.|.::|..:.:.:::.|.|:|.||.||..|||..:.::|.||:|
  Rat   808 TRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 872

  Fly   901 NAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTM 965
            ...:::|:.:|.:.:||||:|.|.|||..|.||......|.:.:|.......:|....|:..|..
  Rat   873 GQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFT 937

  Fly   966 QASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQ 1030
            ||..:|:||....:|..||:...:.|::::.|...:::|:|.:.|..:|.|.::.|.::...:.:
  Rat   938 QAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIR 1002

  Fly  1031 ILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVG 1094
            |:::.|:|.|     .:|...:.|:.|| |::.|:.|.|||||:..:|.||.|||.||||:||||
  Rat  1003 IIEKIPEIDS-----YSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVG 1062

  Fly  1095 HSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYG 1159
            .|||||||.||||:|:|||..||:.:|..:|: .|.:..:|..||||||||.||:.|||||||||
  Rat  1063 SSGCGKSTVVQLLERFYDPMAGTVFLDGKEIK-QLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1126

  Fly  1160 DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLL 1224
            ||.|.||..||:.|||.||.|.||.|||..|:||:|.:||||||||||||||||||||.|.||||
  Rat  1127 DNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1191

  Fly  1225 DEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG 1289
            ||||||||.:||::||:|||.|..|||||||||||||:||||:|.|||||||.|.|.|.||::|.
  Rat  1192 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQK 1256

  Fly  1290 GIYAKLHKTQ 1299
            |||..:...|
  Rat  1257 GIYFSMVSVQ 1266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 527/1220 (43%)
ABC_membrane 108..354 CDD:279056 84/245 (34%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 138/239 (58%)
ABC_membrane 736..1006 CDD:279056 89/270 (33%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 159/239 (67%)
Abcb1aNP_596892.1 PTZ00265 51..1259 CDD:240339 532/1257 (42%)
ABC_membrane 54..335 CDD:279056 94/306 (31%)
ABC_MTABC3_MDL1_MDL2 385..621 CDD:213216 138/235 (59%)
ABC_membrane 707..978 CDD:279056 89/270 (33%)
ABC_MTABC3_MDL1_MDL2 1027..1266 CDD:213216 159/239 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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