Protein Alignment Mdr65 and LOC1276927

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_316337.5
• Gene: LOC1276927 / 1276927
• VectorBaseID: AGAMI1_007925
• Length: 718
• Species: Anopheles gambiae
• Alignment Length: 610
• Identity: 211/610 - (34%)
• Similarity: 315/610 - (51%)
• Gaps: 69/610 - (11%)

  Fly   729 WCYL------ILGTI-SAVAVGFLYPAFAVIFGEF------YAALAEKDPEDA-----LRRTAVL 775
            |.||      ::|.: :|:||.:.......:.|..      ||..:.||...|     :|..|:
Mosquito   127 WHYLRRHLGKLIGAVMAALAVAYFNIQIPNLLGVIVNKLARYAGSSLKDINTASFFRDMRGPAL- 190

  Fly   776 SWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSG 840
              ...|:........||...|.:..|..:...:|...|..::.|::.:||  :|..|.|..||:.
Mosquito   191 --QLFGMYLAQSGFTFLYILLLSQIGEQMAASIRQDLFKQIIIQDLEFFD--HNRTGELVNRLTA 251

  Fly   841 EAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNW---KLALLCLANCPIIVGSVILEAKMMSNA 902
            :..|.:.:....:|   |.|.:|...|...:...|   :||.:.|.:.|:.|....|..:.:.:.
Mosquito   252 DVQDFKSSFKQCIS---QGLRSFAQLVGGGISLFWISPQLASIALVSVPVAVAMFSLLGRSLRHL 313

  Fly   903 VVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTE-EIQRVE----VLIRQKLRWRGVLN 962
            ..:.:...|.|..::.|:::|||||   |..|.   ||:| |:.|||    .::.|:|   |...
Mosquito   314 SKKAQAQSERATSVSEEALSNIRTV---RASAS---EYSEIELFRVETDKSAVLSQQL---GAGI 369

  Fly   963 STMQASAFFA----YAVALCYGGVLVSEGQLPFQDIIK-------VSETLLYGSMMLAQSLAFTP 1016
            :..||.:...    ....|..||..:|...:...|::.       |..:|..||::|...:
Mosquito   370 AVFQALSNLCLNGMVLTTLLLGGHFMSANSISAGDLMAFLVAAQGVQRSLAQGSILLGSVI---- 430

  Fly  1017 AFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLD 1081
               ..:.||.|:|:.|..:|::....|.|    ....||...:|:..:||.|||||:.::|...:
Mosquito   431 ---RGMTAGARVFEFLSLEPRVDLKHGLI----IPDSNLRGEIRFEEVQFIYPTRPNQRVLKDFN 488

  Fly  1082 LEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKL-GIVSQEP 1145
            |.:..||||||||.||.||||...||:|:|:|..|.|.||..::.| |....:|.:| |.:.|:|
Mosquito   489 LVLRPGQTVALVGASGSGKSTVAALLERFYEPTAGRITIDGYELGH-LAPSWLRGELIGFIEQQP 552

  Fly  1146 TLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIA 1210
            .||..:|.|||.||  |.:.:..|::.|||.:.:|.|:..||:||:|.:|.||.||||||:||||
Mosquito   553 VLFGTTIYENIRYG--RPNATREEVMEAAKMSQSHEFVSRLPDGYETMVGERGIQLSGGQRQRIA 615

  Fly  1211 IARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQ 1275
            |||||::.|.||:|||||||||..||.:||:|||.|...||.:||||||||::|||||.|:..||
Mosquito   616 IARALLKQPTILILDEATSALDAASEAVVQRALDAAVLDRTTLVIAHRLSTIRNADVIVVLDQGQ 680

  Fly  1276 VVEQGNHMQLISQGGIYAKLHKTQK 1300
            :||.|.|..|:...|.|.:|.|.|:
Mosquito   681 IVEVGTHDSLLKAQGYYYELVKQQE 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	210/607 (35%)
LOC1276927	XP_316337.5	None