Protein Alignment Mdr65 and ABCB8

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001269220.1
• Gene: ABCB8 / 11194
• HGNCID: 49
• Length: 735
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 209/601 - (34%)
• Similarity: 311/601 - (51%)
• Gaps: 65/601 - (10%)

  Fly    60 LTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILL 124
            |.|..:|.:.:::|...|...|....:.:.|.|.|:|....||                 :|.|:
Human   167 LLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLT-----------------FGYLV 214

  Fly   125 TIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIR 189
            .::.                |..|....||..||||::||||.:.|..........:..||::.:
Human   215 LLSH----------------VGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFK 263

  Fly   190 DG----ISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQ 250
            ..    ||:.:..... |.|.::::::   ...:|||.:....|.::.:...:.....||:.:.|
Human   264 SSFKLVISQGLRSCTQ-VAGCLVSLSM---LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQ 324

  Fly   251 ESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKG----AFSGLSDAVLKSM 311
            |..|.|..:|:|.|.::|||.:|..|:.|.:||...|...|..::..|    .|.|||:.....|
Human   325 EQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCM 389

  Fly   312 LYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESF--ATARG-- 372
            :    .|..:.|.:|      |..::.|...||    ..:|.:..:.|:...|...  ...||
Human   390 V----LGTLFIGGSL------VAGQQLTGGDLM----SFLVASQTVQRSMANLSVLFGQVVRGLS 440

  Fly   373 CATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            ....:|:.:.|...| |||....:....|||.|.||:|.|.||.||...|.:...:.:..|:.||
Human   441 AGARVFEYMALNPCI-PLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVA 504

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSN-IAVVGQEPVLFLGTIAQNI 501
            |||.||.||:|...||:|||||..|.|:||..|:|..:..|||.. :..:.||||||..||.:||
Human   505 LVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENI 569

  Fly   502 SYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILL 566
            .:||..|:.:|:..||.:|.||||||:.||.|.:::||||:.||||||||:|||||||:.|.:|:
Human   570 RFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLI 634

  Fly   567 LDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMAL 631
            |||||||||.:||:.||:|||.||.|||.:|::||||.:|||..||.:.||:|.|.|:|::|:..
Human   635 LDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK 699

  Fly   632 EGAYYNMVRAGDINMP 647
            .|.|..::|...::.|
Human   700 GGLYAELIRRQALDAP 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	202/570 (35%)
		ABC_membrane	108..354	CDD:279056	58/253 (23%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	125/237 (53%)
		ABC_membrane	736..1006	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216
ABCB8	NP_001269220.1	MdlB	165..713	CDD:224055	208/597 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..735		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810