Protein Alignment Mdr65 and LOC100496268

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_004921510.2
• Gene: LOC100496268 / 100496268
• XenbaseID: XB-GENE-29083099
• Length: 1284
• Species: Xenopus tropicalis
• Alignment Length: 1304
• Identity: 556/1304 - (42%)
• Similarity: 785/1304 - (60%)
• Gaps: 74/1304 - (5%)

  Fly    14 KSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVD 78
            |.:.|.|      ||  :....:||:|:..:...:.||.|........||.::|::.:.|...|
 Frog    39 KEKTEKP------PT--VGVFTMFRYSSTSDRILMLFGTIASISHGAALPLMMIVFGDMTDSFV- 94

  Fly    79 RAMQFGTSSNVHALPLFGGG----KTLTNASREENNE----ALYDDSISYGILLTIASVVMFISG 135
                     ||..:   |.|    :.|.||||....:    |.|...:.:|:||.....:.|
 Frog    95 ---------NVGQV---GSGNFSLEALINASRNLQEQMTTYAYYYSGLGFGVLLFAYVQISF--- 144

  Fly   136 IFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFV 200
                  :.:.|.:|:.|:|...|.:|:||:|||.|:.........:.|||.||.:||.:|:...:
 Frog   145 ------WTLSAGKQIKRIRSNFFHAVLRQEIGWFDVNDAGELNTRLTDDVSKINEGIGDKIAMLL 203

  Fly   201 YLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILS 265
            ..:..|:....|.|..||||||.:.:..|::.......||.....|.:|.::||.||.:|||:||
 Frog   204 QSLTTFVTGFIIGFVKGWKLTLVILAISPVMGFSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLS 268

  Fly   266 SIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
            |||||.:|||:..|::|||..|..|::....|...:.:|......|:|.:.|.|||||..|||
 Frog   269 SIRTVFAFGGQDKEIKRYEKNLEEAKRIGIKKAITANVSIGFAFLMIYAAYALAFWYGTTLII-- 331

  Fly   331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGK 395
                |..||...::..||.:|:||..:.:|:|.:|:||.|||.|..:|.:||...|||..|.:|
 Frog   332 ----NGGYTIGSVLTVFFAVIIGAFAVGQTSPNVEAFANARGAAYTIFNIIDNQPKIDSFSKEG- 391

  Fly   396 LLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPV 460
            |....::||:||::|.|.||||.::.|.:|||:.|.:|:||||||||||||||.|||:||||||.
 Frog   392 LKPDKIKGDIEFKNVKFTYPSRTDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPE 456

  Fly   461 FGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEF 525
            .|.:.||..|||..||::||..|.||.|||:||..|||.||.||:...|.:|||.|..:|.|:.|
 Frog   457 EGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTMEEIERATKEANAYNF 521

  Fly   526 ITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLAS 590
            |..||:.:.:::||||:||||||||||||||||::|||||||||||||||.:||..||.|||.|.
 Frog   522 IMKLPDKFETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAR 586

  Fly   591 KGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDS 655
            :|||||||:||||.||.||.|....:|.::|:|.|.:||...|.|:|:|         .::..::
 Frog   587 EGRTTIVVAHRLSTIRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNLV---------TLQTVET 642

  Fly   656 IEDTKQK-SLALFEK---SFETSPLNFEKGQKNSV-QFEEPIIKALIKDTNAQSAEAPPEKPNFF 715
            .:||::. .|.|.||   |..:|.|...|..:::: :..|...|..:.:...:..:.||..
 Frog   643 SKDTEENLELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTETDNKEEVDEEGKKKEDGPPPV---- 703

  Fly   716 RTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRT--AVLSWA 778
             :|.::::|.|.||.|.::|.|.|:..|...||||:||.:.....|....|...:.|  ::|..|
 Frog   704 -SFLKVMRLNKTEWPYFVVGIICAMINGATQPAFAIIFSKIIGVFAGPASEMRAKSTMYSLLFLA 767

  Fly   779 CLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAV 843
            ..|::|:|   .|||.:.|..||..||.|:|..:|.:|:.||:|||||..||.|||:.||:.:|.
 Frog   768 LGGISFIT---FFLQGFTFGKAGEILTKRLRLWSFKSMLRQEIGWFDDTKNSTGALTTRLATDAS 829

  Fly   844 DIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQ 908
            .:|||.|..|:.:.|.::|..::|.::..|.|:|.||.||..|||..|.:::.||.:....::|:
 Frog   830 QVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLILAIVPIIAASALVQLKMFAGHAKKDKK 894

  Fly   909 VIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY 973
            .:|:|.:|:|:::.|||||..|.||......|.:.::.......:|....|:..:..||..:|||
 Frog   895 ELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKNLEGPYRNSIKKAHLHGLTYALSQAIMYFAY 959

  Fly   974 AVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI 1038
            |....:|..||:|..:...|:..|...:::|:|.|.|:.:|.|.::.|:|:...:|.:|:|.|.|
 Frog   960 AGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPLI 1024

  Fly  1039 QSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTC 1103
            .|    ......|..|....|:::|:||.||||||..:|.|||:.|.:|:|:||||.|||||||.
 Frog  1025 DS----YSKEGEKPQNCGGNVQFQGVQFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTT 1085

  Fly  1104 VQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMV 1168
            |.||:|:|||..|.:.:|...:: ||.:..||.::|||||||.||:.||.||||||||.|.|:..
 Frog  1086 VSLLERFYDPFGGEVLVDGHSVR-DLNIQWVRAQMGIVSQEPILFDCSIGENIAYGDNSREVTQA 1149

  Fly  1169 EIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDL 1233
            ||..|||.||.||||.:|.:.|:||:|.:|||:||||||||||||||||.||||||||||||||.
 Frog  1150 EIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGGQKQRIAIARALVRKPKILLLDEATSALDT 1214

  Fly  1234 QSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKT 1298
            :||::||:|||.|.:|||||||||||||:||||.|.|||||:|||||.|.||:...|:|..|...
 Frog  1215 ESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYYTLVTI 1279

  Fly  1299 QKDH 1302
            |..|
 Frog  1280 QLGH 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	244/522 (47%)
		MdlB	711..1299	CDD:440747	269/589 (46%)
LOC100496268	XP_004921510.2	PTZ00265	1..1279	CDD:240339	554/1298 (43%)