Protein Alignment Mdr65 and LOC100494753

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_017951387.2
• Gene: LOC100494753 / 100494753
• -ID: -
• Length: 1319
• Species: Xenopus tropicalis
• Alignment Length: 1316
• Identity: 528/1316 - (40%)
• Similarity: 778/1316 - (59%)
• Gaps: 65/1316 - (4%)

  Fly    14 KSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALT-LPAVVIIYSEFTSMLV 77
            |.:|:...|    |...:.||:||.|:...:|..:..| |:|.:.|.| ||.::|::...|...|
 Frog    42 KKKEKKDSA----PVAMVGFLELFSFADSWDIMLMIIG-IVCGLAAGTGLPIMIIVFGTMTDSFV 101

  Fly    78 DRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVF 142
            ...:....:.|........|.....:...|....|.|..:|...|         |:..:|.|..|
 Frog   102 QSGIPVNYTQNTSTTSTSCGHFGTMDIEAEMTKYAYYYVAIGCSI---------FVLSLFQVWTF 157

  Fly   143 NMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFI 207
            .:.|.||.||:|...|.:|:.|::.|.|..........:.:|:..|.:|:.:|:..|:.....||
 Frog   158 LVSASRQTTRIRRMFFKAVLHQEMSWFDATQIGTLNTRLTEDINTIHEGLGDKISIFLQFFSTFI 222

  Fly   208 ITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVS 272
            ..:.|.|.:||||||.:.|..||:........|.....|::|..:|..||.:|||:|::|||||:
 Frog   223 SGIIIGFVHGWKLTLVIMSVSPLLGASAAVWTKLLANFTSKELNAYGKAGAVAEEVLTAIRTVVA 287

  Fly   273 FGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKE 337
            |.|:|..:::|:..|..|:|....|...:.||..:.:.:::.:.|..||||..|.:|    |...
 Frog   288 FNGQKKALKQYDKHLENAKKVGIRKSITTNLSMGIAQFLIFGAYALGFWYGTKLTVD----EPDT 348

  Fly   338 YTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLR 402
            ||...::|.||.:::|..::.:.||.|||.|:|||.|..::|:|.....||..||:|...: .|.
 Frog   349 YTIGKVLIVFFSVLIGTFSLGQAAPNLESIASARGAAFEVYKIIKQPRLIDSSSTEGHKPD-RLM 412

  Fly   403 GDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLD 467
            |::||:::.|.|||||::.:.:|||:.:..|:|:||||:|||||||.:|||||||||..|.:.:|
 Frog   413 GNIEFKNIHFSYPSRPDIQILKGLNLNVETGKTIALVGASGCGKSTTIQLLQRFYDPPKGEITVD 477

  Fly   468 DLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPES 532
            ..|||..|::|||.||.||.||||||..||.:||.||:...|..|||.|:.:|.|::||..||:.
 Frog   478 GHDIRTLNVKWLRENIGVVSQEPVLFGATIKENIQYGREDVTDAEIEQASKEANAYDFIQKLPDK 542

  Fly   533 YRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIV 597
            :.:|:||||:||||||||||||||||::|||||||||||||||.|||..||.|||.|..||||||
 Frog   543 FETMVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTQSEAIVQSALDKARAGRTTIV 607

  Fly   598 VSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---------------RAGDINMP 647
            ::||||.||.||.|...|:|.|:|:|:|::||..:|.||::|               ..|:.:..
 Frog   608 IAHRLSTIRTADVIAGFHNGVVVEQGNHNELMNQKGVYYSLVMLQSHGKHKEEDSSQSEGEESSN 672

  Fly   648 DEVEKE------DSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAE 706
            .:.|.|      :.:||....|..:....|:......:..:|:....:.   |....:||....:
 Frog   673 SDEENEGNVYENEIVEDYNNGSENISRNDFQRKSSRRKSKRKSKKSSKS---KKATDNTNKVEED 734

  Fly   707 APPEKPNFFRTFS--RILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDAL 769
            .|        |||  ::|.:.|.||.|:::|.|::...|.:||.||||||:...:....||:...
 Frog   735 LP--------TFSLGKVLAMNKPEWYYIVIGVIASAINGGIYPTFAVIFGKIIGSFQITDPDKRS 791

  Fly   770 RRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGAL 834
            ..|.:||...|.|..|:.:|..:..:.|..:|..||.|:|::.|.|::.||:|:|||..|:||.|
 Frog   792 AETVLLSLMFLVLGGLSLIVYIILGFAFGISGENLTMRLRSLCFKALIRQEIGYFDDHANAVGVL 856

  Fly   835 SARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMM 899
            ..||:.:|..::||.|..:..:..::...::::.:|..|.|:|.||.||..|.::|:..:..|.|
 Frog   857 LTRLATDASQVKGATGSRIGLITLSVCTLLAAIIIAFVYGWQLTLLILACVPFLIGANFIRMKSM 921

  Fly   900 SNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTE--EIQRVEVLIRQKLRWRGVLN 962
            :....::::.:|:|.:|:||::.|||||..|.||......|.|  .:...|.:::..|  .|...
 Frog   922 AGHASKDQKALEQAGKISTEAVGNIRTVVSLTREERFYERYNESLSVPYKETIVKAPL--YGFTY 984

  Fly   963 STMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHR 1027
            :..|...||..|....:|..|::...|.|:::..|...:::.:|.:.||.:..|.|..|.::..|
 Frog   985 AISQCMNFFVNAAVFRFGAWLIAHCYLQFENVFIVFSAIIFAAMNVGQSTSLAPDFGKARVSAQR 1049

  Fly  1028 LFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVA 1091
            :.::|:|||:|.|     .:....:|:.|:| :.:|.::|.|||||..::|.||:::|.||||:|
 Frog  1050 IMKLLERKPQIDS-----YSEDGDKLSSFDGNLEFRNVKFVYPTRPKVQVLQGLNVKVSKGQTLA 1109

  Fly  1092 LVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENI 1156
            |||.|||||||.||||:|:|||.||.:..|..|.:. |.:..:|::||||||||.||:.||||||
 Frog  1110 LVGSSGCGKSTSVQLLERFYDPMEGQVFADGIDTKL-LNIQWLRSQLGIVSQEPILFDCSIAENI 1173

  Fly  1157 AYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKI 1221
            .||...|.|:..||..|||:||.||||..|||.|:||:|.:|.||||||||||||||||:|.||:
 Frog  1174 QYGFLERQVTQEEIEEAAKAANIHSFIEGLPNKYNTRVGDKGAQLSGGQKQRIAIARALIRKPKV 1238

  Fly  1222 LLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI 1286
            |||||||||||.:||::||.|||.|..||||:||||||:|:||||:|.|||||.|:|||.|.||:
 Frog  1239 LLLDEATSALDTESEKVVQNALDNARQGRTCVVIAHRLTTIQNADIIAVIQNGIVIEQGTHGQLL 1303

  Fly  1287 SQGGIYAKLHKTQKDH 1302
            ::.|.|..|..:|..|
 Frog  1304 AKQGAYYALVNSQVAH 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	505/1234 (41%)
		ABC_membrane	108..354	CDD:279056	75/245 (31%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	141/251 (56%)
		ABC_membrane	736..1006	CDD:279056	82/271 (30%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	148/239 (62%)
LOC100494753	XP_017951387.2	PTZ00265	71..1310	CDD:240339	514/1272 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7270
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930