Protein Alignment Mdr65 and abcb1 (provisional)

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_017950348.2
• Gene: abcb1 (provisional) / 100494740
• XenbaseID: XB-GENE-950725
• Length: 1381
• Species: Xenopus tropicalis
• Alignment Length: 1379
• Identity: 551/1379 - (39%)
• Similarity: 802/1379 - (58%)
• Gaps: 123/1379 - (8%)

  Fly     8 TSSSEG--KSQEEAPMAEGLEPT-EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIY 69
            |:.:||  ||.|||......:|: |.:.||.:.||:...:|..:..|..........||.::|::
 Frog    35 TADNEGAPKSNEEARKNSSDKPSKEMVGFLDMVRFADAWDILLMITGLFCAVANGTGLPLLIIVF 99

  Fly    70 SEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFIS 134
            .:.|...|...:.....|...::|.......:|..|             .|.|.|..|   :|:.
 Frog   100 GDMTDSFVLSGINVTNVSGCGSIPGIDLEAKMTRYS-------------YYYIGLGSA---VFVL 148

  Fly   135 GIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHF 199
            .:..:..|.:.|.||:.|:|...|.:|:.||:.|.|..........:.||:..|.:|:.:|:..|
 Frog   149 SLIQIWTFLVSATRQIMRIRQIFFKAVLHQDMAWFDSNQVGTLNTRLTDDINTIHEGLGDKMCIF 213

  Fly   200 VYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEIL 264
            |..:..|:..:.:.|.:||||||.:.|..||:........|.....|.:|..:||.||.:|||||
 Frog   214 VQFLSSFVSGIVVGFVHGWKLTLVILSVSPLLGASAAIWTKLVASFTTKELHAYAKAGAVAEEIL 278

  Fly   265 SSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIID 329
            ::||||::|.|:|....:|:..|:.|:.....|...:.:|..:.:.:::.:.|.|||||..|.:|
 Frog   279 TAIRTVIAFNGQKKAQDKYDANLITAKTVGIKKAVTTNVSMGLSQFLIFGAYALAFWYGTKLTVD 343

  Fly   330 DRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDG 394
                |.:.||...::|.||.::||...:.:..|.:||.|.|||.|..::.:|:....||..|.:|
 Frog   344 ----EPETYTIGKVLIVFFSVLVGTFALGQATPNIESLANARGAAFAVYNIINKHRPIDSSSEEG 404

  Fly   395 KLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDP 459
            ...| .|:||:||:::.|.||.||:|.:..|||:::.||:|:||||.|||||||.:|||||||||
 Frog   405 HKPN-RLKGDIEFKNIHFAYPCRPDVQILSGLNLKVEAGKTIALVGMSGCGKSTTIQLLQRFYDP 468

  Fly   460 VFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHE 524
            ..|.:.||..|||..|::|||.||.||.||||||..|||:||.:|:...|..|||.||.:|.|.:
 Frog   469 SHGEITLDGHDIRTLNVKWLRENIGVVSQEPVLFGTTIAENIRFGRESVTDSEIEQAAKEANAFD 533

  Fly   525 FITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLA 589
            ||:.||:.:::|:||||:||||||||||||||||::|||||||||||||||.|||..||.|||.|
 Frog   534 FISRLPDKFKTMVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTQSEAIVQAALDKA 598

  Fly   590 SKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAGDINMPDEVE 651
            ..||||||::||||.||.||.|...|:|.|:|:|||.:||..:|.||::|   :.|:.:.|::.|
 Frog   599 RAGRTTIVIAHRLSTIRTADVIAGFHNGVVVEKGSHSELMTKKGVYYSLVMLQKQGEDSGPEDNE 663

  Fly   652 KED-SIEDTKQKSLALFEKSFETSPLN--------FE----KGQKNSVQFEEPIIKALIKDTNAQ 703
            :|: |..:|::..|.....|.|..|.:        |.    :|:.::|..::..::......|.:
 Frog   664 QEEHSFLETEETYLNEDCLSPEADPAHQAVECTDFFRRESFRGRNDTVNNKKSTLRKSKSLENIK 728

  Fly   704 SA-EAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGE------------ 755
            .| |..||.     :.:|||||.|.||.|:::|.|:|...|.:||.||||||:
 Frog   729 EAKEILPEV-----SLNRILQLNKPEWLYIVIGIIAAAISGGIYPTFAVIFGKVIGAGVHYSFIH 788

  Fly   756 -----------------FYA---------------------------------ALAEKDPEDALR 770
                             ||:                                 |..|:||....:
 Frog   789 MIHEFLFILIKSGSQQRFYSDVLLTFGLACYFISNAGNYEYVFFFYLIRCLLQAFQEQDPVKKSQ 853

  Fly   771 RTAVLSWACLGLAFLTGLVCF----LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSV 831
            |||:||.    :.|:.||:.|    ...::|..:|..||.|:|:::|.|::.||:|:|||..|:|
 Frog   854 RTALLSL----MFFVLGLISFAVHITMGFMFGKSGENLTMRLRSLSFKALLGQEIGFFDDHRNAV 914

  Fly   832 GALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEA 896
            |.|..||:.:|..|:||.|..|..:...:...::::.:|..:.|:|.||.||..|.::|:.|:..
 Frog   915 GVLLTRLATDASQIKGAAGSQLGLITMTVCTLLAAILIAFIHGWQLTLLILACIPFLIGTNIIRM 979

  Fly   897 KMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVL 961
            ..::....::::.:|||.||:||::.|||||..|.:|.....:|...:.....:...|.|..||.
 Frog   980 TSVAGHASKDQKALEEAGRISTEAVENIRTVVSLTKEEVFYEKYNASLNGPYRVALGKARMYGVT 1044

  Fly   962 NSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGH 1026
            .:..|...:|..|....:|..|::...:.|:.:..|...:::.:|.:.||.:|.|.|..|..:..
 Frog  1045 YAIAQCINYFVNAAVFRFGAWLIANCYMEFESVFVVFSAIVFAAMSVGQSNSFAPDFGKAKSSAQ 1109

  Fly  1027 RLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTV 1090
            |:|.:|||||.|.|     .:...:.||.||| :.::.::|.|||||:.::|.||:::||||||:
 Frog  1110 RMFLLLDRKPAIDS-----YSNEGETLNEFEGNLEFKNVKFVYPTRPNVQVLQGLNVKVLKGQTL 1169

  Fly  1091 ALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAEN 1155
            ||||.|||||||.:|||:|:|||.||.:..|..|.: .|.:..:|::||:|||||.||:.||.||
 Frog  1170 ALVGSSGCGKSTLIQLLERFYDPMEGNVLADGVDTK-SLNIQWLRSQLGLVSQEPILFDCSIGEN 1233

  Fly  1156 IAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPK 1220
            |.||||.|.|:..|:..|||:||.|:|:.|||.|||||:|.:|.||||||||||||||||||.||
 Frog  1234 IRYGDNNRVVTQDEVAEAAKTANIHTFVESLPQGYDTRVGDKGAQLSGGQKQRIAIARALVRKPK 1298

  Fly  1221 ILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQL 1285
            :|||||||||||.:||::||:|||.|..|||||||||||:||||||||.|||||:|||||.|.||
 Frog  1299 VLLLDEATSALDTESEKVVQKALDDARKGRTCIVIAHRLTTVQNADVIAVIQNGEVVEQGTHNQL 1363

  Fly  1286 ISQGGIYAKLHKTQ 1299
            :::.|.|..|..:|
 Frog  1364 LAKQGAYYALINSQ 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	237/525 (45%)
		MdlB	711..1299	CDD:440747	270/654 (41%)
abcb1 (provisional)	XP_017950348.2	PTZ00265	77..1371	CDD:240339	533/1329 (40%)