Protein Alignment Mdr65 and XB950724

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_017950348.2
• Gene: XB950724 / 100494740
• XenbaseID: XB-GENE-950725
• Length: 1381
• Species: Xenopus tropicalis
• Alignment Length: 1379
• Identity: 551/1379 - (39%)
• Similarity: 802/1379 - (58%)
• Gaps: 123/1379 - (8%)

  Fly     8 TSSSEG--KSQEEAPMAEGLEPT-EPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIY 69
            |:.:||  ||.|||......:|: |.:.||.:.||:...:|..:..|..........||.::|::
 Frog    35 TADNEGAPKSNEEARKNSSDKPSKEMVGFLDMVRFADAWDILLMITGLFCAVANGTGLPLLIIVF 99

  Fly    70 SEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFIS 134
            .:.|...|...:.....|...::|.......:|..|             .|.|.|..|   :|:.
 Frog   100 GDMTDSFVLSGINVTNVSGCGSIPGIDLEAKMTRYS-------------YYYIGLGSA---VFVL 148

  Fly   135 GIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHF 199
            .:..:..|.:.|.||:.|:|...|.:|:.||:.|.|..........:.||:..|.:|:.:|:..|
 Frog   149 SLIQIWTFLVSATRQIMRIRQIFFKAVLHQDMAWFDSNQVGTLNTRLTDDINTIHEGLGDKMCIF 213

  Fly   200 VYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEIL 264
            |..:..|:..:.:.|.:||||||.:.|..||:........|.....|.:|..:||.||.:|||||
 Frog   214 VQFLSSFVSGIVVGFVHGWKLTLVILSVSPLLGASAAIWTKLVASFTTKELHAYAKAGAVAEEIL 278

  Fly   265 SSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIID 329
            ::||||::|.|:|....:|:..|:.|:.....|...:.:|..:.:.:::.:.|.|||||..|.:|
 Frog   279 TAIRTVIAFNGQKKAQDKYDANLITAKTVGIKKAVTTNVSMGLSQFLIFGAYALAFWYGTKLTVD 343

  Fly   330 DRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDG 394
                |.:.||...::|.||.::||...:.:..|.:||.|.|||.|..::.:|:....||..|.:|
 Frog   344 ----EPETYTIGKVLIVFFSVLVGTFALGQATPNIESLANARGAAFAVYNIINKHRPIDSSSEEG 404

  Fly   395 KLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDP 459
            ...| .|:||:||:::.|.||.||:|.:..|||:::.||:|:||||.|||||||.:|||||||||
 Frog   405 HKPN-RLKGDIEFKNIHFAYPCRPDVQILSGLNLKVEAGKTIALVGMSGCGKSTTIQLLQRFYDP 468

  Fly   460 VFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHE 524
            ..|.:.||..|||..|::|||.||.||.||||||..|||:||.:|:...|..|||.||.:|.|.:
 Frog   469 SHGEITLDGHDIRTLNVKWLRENIGVVSQEPVLFGTTIAENIRFGRESVTDSEIEQAAKEANAFD 533

  Fly   525 FITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLA 589
            ||:.||:.:::|:||||:||||||||||||||||::|||||||||||||||.|||..||.|||.|
 Frog   534 FISRLPDKFKTMVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTQSEAIVQAALDKA 598

  Fly   590 SKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAGDINMPDEVE 651
            ..||||||::||||.||.||.|...|:|.|:|:|||.:||..:|.||::|   :.|:.:.|::.|
 Frog   599 RAGRTTIVIAHRLSTIRTADVIAGFHNGVVVEKGSHSELMTKKGVYYSLVMLQKQGEDSGPEDNE 663

  Fly   652 KED-SIEDTKQKSLALFEKSFETSPLN--------FE----KGQKNSVQFEEPIIKALIKDTNAQ 703
            :|: |..:|::..|.....|.|..|.:        |.    :|:.::|..::..::......|.:
 Frog   664 QEEHSFLETEETYLNEDCLSPEADPAHQAVECTDFFRRESFRGRNDTVNNKKSTLRKSKSLENIK 728

  Fly   704 SA-EAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGE------------ 755
            .| |..||.     :.:|||||.|.||.|:::|.|:|...|.:||.||||||:
 Frog   729 EAKEILPEV-----SLNRILQLNKPEWLYIVIGIIAAAISGGIYPTFAVIFGKVIGAGVHYSFIH 788

  Fly   756 -----------------FYA---------------------------------ALAEKDPEDALR 770
                             ||:                                 |..|:||....:
 Frog   789 MIHEFLFILIKSGSQQRFYSDVLLTFGLACYFISNAGNYEYVFFFYLIRCLLQAFQEQDPVKKSQ 853

  Fly   771 RTAVLSWACLGLAFLTGLVCF----LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSV 831
            |||:||.    :.|:.||:.|    ...::|..:|..||.|:|:::|.|::.||:|:|||..|:|
 Frog   854 RTALLSL----MFFVLGLISFAVHITMGFMFGKSGENLTMRLRSLSFKALLGQEIGFFDDHRNAV 914

  Fly   832 GALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEA 896
            |.|..||:.:|..|:||.|..|..:...:...::::.:|..:.|:|.||.||..|.::|:.|:..
 Frog   915 GVLLTRLATDASQIKGAAGSQLGLITMTVCTLLAAILIAFIHGWQLTLLILACIPFLIGTNIIRM 979

  Fly   897 KMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVL 961
            ..::....::::.:|||.||:||::.|||||..|.:|.....:|...:.....:...|.|..||.
 Frog   980 TSVAGHASKDQKALEEAGRISTEAVENIRTVVSLTKEEVFYEKYNASLNGPYRVALGKARMYGVT 1044

  Fly   962 NSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGH 1026
            .:..|...:|..|....:|..|::...:.|:.:..|...:::.:|.:.||.:|.|.|..|..:..
 Frog  1045 YAIAQCINYFVNAAVFRFGAWLIANCYMEFESVFVVFSAIVFAAMSVGQSNSFAPDFGKAKSSAQ 1109

  Fly  1027 RLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTV 1090
            |:|.:|||||.|.|     .:...:.||.||| :.::.::|.|||||:.::|.||:::||||||:
 Frog  1110 RMFLLLDRKPAIDS-----YSNEGETLNEFEGNLEFKNVKFVYPTRPNVQVLQGLNVKVLKGQTL 1169

  Fly  1091 ALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAEN 1155
            ||||.|||||||.:|||:|:|||.||.:..|..|.: .|.:..:|::||:|||||.||:.||.||
 Frog  1170 ALVGSSGCGKSTLIQLLERFYDPMEGNVLADGVDTK-SLNIQWLRSQLGLVSQEPILFDCSIGEN 1233

  Fly  1156 IAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPK 1220
            |.||||.|.|:..|:..|||:||.|:|:.|||.|||||:|.:|.||||||||||||||||||.||
 Frog  1234 IRYGDNNRVVTQDEVAEAAKTANIHTFVESLPQGYDTRVGDKGAQLSGGQKQRIAIARALVRKPK 1298

  Fly  1221 ILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQL 1285
            :|||||||||||.:||::||:|||.|..|||||||||||:||||||||.|||||:|||||.|.||
 Frog  1299 VLLLDEATSALDTESEKVVQKALDDARKGRTCIVIAHRLTTVQNADVIAVIQNGEVVEQGTHNQL 1363

  Fly  1286 ISQGGIYAKLHKTQ 1299
            :::.|.|..|..:|
 Frog  1364 LAKQGAYYALINSQ 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	529/1293 (41%)
		ABC_membrane	108..354	CDD:279056	74/245 (30%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	145/239 (61%)
		ABC_membrane	736..1006	CDD:279056	88/335 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	151/239 (63%)
XB950724	XP_017950348.2	PTZ00265	77..1371	CDD:240339	533/1329 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7270
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010