DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and abcb11.2

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:XP_004917764.1 Gene:abcb11.2 / 100489579 XenbaseID:XB-GENE-988819 Length:1349 Species:Xenopus tropicalis


Alignment Length:1370 Identity:539/1370 - (39%)
Similarity:796/1370 - (58%) Gaps:132/1370 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            :....|:...|.|.:.|..:..|        |.:||||:|..|...:.||.:...|.....|.::
 Frog    34 QNGNASSKKDESKKKPEDSIRVG--------FFQLFRFATCSETTMMLFGSLAAIIHGAAQPCML 90

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDD----SISYGIL---L 124
            :::    .:::|..:::    ::....|....||.||.:....|.:|..|    :.|.|:|   |
 Frog    91 LVF----GLMIDTFIEY----DIEMQELRDPNKTCTNNTITWTNGSLVPDKDNKTFSCGMLDIEL 147

  Fly   125 TIASVVMFISGI---------FSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQS 180
            .:.:...:.:||         ..:..:...|.||:.|:|...|..|:|.:|||.|..|.......
 Frog   148 EMTNFASYYAGIGCSVLILGYMQICFWVTAAARQIQRIRKLYFRKVMRMEIGWFDCTSVGELNTR 212

  Fly   181 MVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKL 245
            |.||:.||.|.|:::||.|:.....|:....:.|..||||||.:.:..||:.:....:|....||
 Frog   213 MSDDINKINDAIADQVGIFIQRFTTFLSGFLLGFVNGWKLTLIIIAVSPLIGVGAALMALAVAKL 277

  Fly   246 TAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKS 310
            |.||..:||.||.:|:|:||.||||.:||||..||.||:..||.|::....||...|.....:..
 Frog   278 TGRELLAYAKAGAVADEVLSGIRTVAAFGGETKEVDRYDRNLVYAQRWGIRKGIIMGFFTGYMWF 342

  Fly   311 MLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCAT 375
            :::|..|.|||||..|::     |.:||:|..|:..|.|::|||.|:.:.:|.|::||:.||.||
 Frog   343 IIFLCYALAFWYGSKLVL-----EEEEYSPGNLLQVFLGVLVGALNLGQASPCLQAFASGRGAAT 402

  Fly   376 NLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVG 440
            |:|:.||...|||.:|.:|..|: .::|::||.::.|.|||||||.:...:|:.|::|:|.|.||
 Frog   403 NIFETIDNEPKIDCMSEEGYKLD-KVKGEIEFHNISFHYPSRPEVKILDKINMVIKSGETTAFVG 466

  Fly   441 SSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGK 505
            .||.||||.|||:||||||..|.|.||..|||..|||||||.|.:|.||||||..|||:||.|||
 Frog   467 PSGAGKSTTVQLIQRFYDPDVGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFATTIAENIRYGK 531

  Fly   506 PGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
            ..||.:||..||.:|.|:.||.:||:.:.:::||.|.|:||||||||||||||::||:|||||.|
 Frog   532 ENATMEEIITAAKEANAYNFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMA 596

  Fly   571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAY 635
            |||||.:||..||:|||....|||||.::||||.|:.||.||....|:.:|:|:||:|:..:|.|
 Frog   597 TSALDNESEAIVQEALDKVRFGRTTISIAHRLSTIKNADVIVGFEHGRAVEKGTHDELLERKGVY 661

  Fly   636 YNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEP--------- 691
            :.:|               :::....|:|.           |.||..|::.:||||         
 Frog   662 FTLV---------------TLQSQGDKALH-----------NMEKKDKSNKEFEEPKLETLQPLK 700

  Fly   692 ------IIKALIKD-TNAQSAEAPPEKP------------------------NFFRT-------- 717
                  .::|.|:. :.:|.:...|:.|                        |..:|        
 Frog   701 RGSYQASLRASIRQRSRSQLSNLVPDTPLLVVGADASDPIQHSTHYDDESDNNMIKTEEIVEDIE 765

  Fly   718 ---FSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALA---EKDPEDALRRTAVLS 776
               .:|||:....||.|::.|:|.|...|.:.|.:|::|.:.....:   |::..|.:....|| 
 Frog   766 PAPVARILKYNAPEWPYMLFGSIGAAINGAVSPLYALLFSQILGIFSLPDEEEQRDQINGICVL- 829

  Fly   777 WACLG-LAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSG 840
            :..:| ::|||.   |||.|.|..:|..||.|:|.:.|.:|:.||||||||..||.|||:.||:.
 Frog   830 FVLIGVVSFLTQ---FLQGYTFAKSGELLTRRLRKLGFRSMLGQEVGWFDDPRNSPGALTTRLAT 891

  Fly   841 EAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVR 905
            :|..:|||.|..:..::.|:||...::.:|.|::|||.|:.:...|.:..|..|:|||::....:
 Frog   892 DASQVQGATGSQIGMIVNAISNIGVALIIAFYFSWKLTLVIMCFLPFLAVSGALQAKMLTGFANQ 956

  Fly   906 EKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAF 970
            :|..:|.|.||::|::.||||:||:.:|...:..|.|:::.......:|....|:.....|...|
 Frog   957 DKHAMESAGRISSEALGNIRTIAGIAKEKTFVDMYEEQLEAPYRSAIKKANVYGLCFGFAQCIVF 1021

  Fly   971 FAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRK 1035
            .|..|:..|||.||.:..|.:..:.:|..:::.....|.::.::||.::.|.|:..|.|:::||.
 Frog  1022 IANTVSYRYGGYLVDKEGLHYSFVFRVISSIVTSGTALGRASSYTPDYAKAKISAARFFKLVDRI 1086

  Fly  1036 PKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCG 1099
            |||     ::.....::...|:| :.::..:|.||||||.::|||||:.|..|||:|.||.||||
 Frog  1087 PKI-----SVYTDHGERWPDFKGSIDFQDCKFTYPTRPDIQVLNGLDVSVKPGQTLAFVGSSGCG 1146

  Fly  1100 KSTCVQLLQRYYDPDEGTIHID-HDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRR 1163
            |||.||||:|:||||:|.:.|| |:  ..::.:..:|:|:|||||||.||:.||.|||.||||.:
 Frog  1147 KSTSVQLLERFYDPDKGKVLIDGHN--SKNVNVAFLRSKIGIVSQEPVLFDCSIIENIRYGDNNQ 1209

  Fly  1164 SVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEAT 1228
            .:|..:||.|:|.|..|.|::.||:.|||.:||.|:|||.|||||||||||:||:||||||||||
 Frog  1210 ELSKDKIIEASKKAQLHDFVMGLPDKYDTNVGAHGSQLSRGQKQRIAIARAIVRDPKILLLDEAT 1274

  Fly  1229 SALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYA 1293
            ||||.:||:.||.|||.|..|||||||||||||:||:|:|.|:..|.|:|:|||.:|:.:.|.|.
 Frog  1275 SALDTESEKTVQAALDRAREGRTCIVIAHRLSTIQNSDIIAVMSRGIVIEKGNHEELMEKKGAYY 1339

  Fly  1294 KLHKT 1298
            ||..|
 Frog  1340 KLVTT 1344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 522/1281 (41%)
ABC_membrane 108..354 CDD:279056 90/261 (34%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 135/236 (57%)
ABC_membrane 736..1006 CDD:279056 89/273 (33%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 143/241 (59%)
abcb11.2XP_004917764.1 PTZ00265 159..1340 CDD:240339 506/1223 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 193 1.000 Domainoid score I3127
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.010

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