DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and LOC100485969

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_031758323.1	Gene:	LOC100485969 / 100485969	-ID:	-	Length:	1262	Species:	Xenopus tropicalis

Alignment Length:	1309	Identity:	543/1309 - (41%)
Similarity:	786/1309 - (60%)	Gaps:	67/1309 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVSTSSSE-----GKSQEEAPMAE--GLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALT 61
            |.::..::|     .|:|::..:.|  ..|..:.:..:::|||:...:|..:..|.|......|.
Frog     5 DPINMGNNEEEKCKDKAQDDTVIEEKKEREKQKAVGVIQIFRFADKLDIFLMVIGLIGAAGNGLC 69

  Fly    62 LPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTI 126
            ||.:.::|.:.|    |..:.|.:|              :.|:|.....:.|.:....:.:....
Frog    70 LPMLNLVYGQVT----DSILCFNSS--------------IQNSSECNKFKPLGEQMTIFALYYVA 116

  Fly   127 ASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDG 191
            ....:.:||...|..:.:.|.||..:||...|.||:.|::.|.|:.........:.:|:.||.||
Frog   117 IGAAVIVSGYAQVSFWVLAAARQTRKMRQAFFRSVLSQEMSWFDINKSGEINTRLNEDITKINDG 181

  Fly   192 ISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGA 256
            |.:|:||....|..||..:.::.:.||:|.|...:..||:.|...:.:|....||::|..:||.|
Frog   182 IGDKIGHLFQNVSTFIAGIIVALATGWELALVYIAASPLIALSAAFCSKMLVSLTSKELSAYAAA 246

  Fly   257 GNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFW 321
            |.:|||:||||||||:|||::.|::||.|.|..|:|....:...|.|:..::...:|.|....||
Frog   247 GAVAEEVLSSIRTVVAFGGQEREIKRYTNNLEEAKKIGIKRAIVSQLALGLVFLFIYCSYGLGFW 311

  Fly   322 YGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSK 386
            ||..:|:     :||.||....::.||.:...:..|.:.:...|:|:.|||.|..:|.|:|.|:.
Frog   312 YGTIVIL-----QNKGYTIGDALVIFFSVANSSFCIGQASSHFEAFSIARGAAYKIFNVMDQTAT 371

  Fly   387 IDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQ 451
            ||...|:|.... .::|:|||::|.|.|||||.|.:.:|||::|::||||||||.|||||||.||
Frog   372 IDNYMTEGHRPE-NMKGNVEFKNVSFSYPSRPNVQILKGLNLKIKSGQTVALVGQSGCGKSTTVQ 435

  Fly   452 LLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAA 516
            ||||.||...|:|.:|..|||..|:...|..|.||.||||||..||..||.||:...|..|||.|
Frog   436 LLQRLYDAQEGTVTVDGHDIRSLNVGHYREFIGVVSQEPVLFGTTIKNNIKYGRENVTDLEIEKA 500

  Fly   517 ATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQ 581
            ..:|.|::||..||:.|.:::||||:||||||||||||||||::|||||||||||||||.:||..
Frog   501 VKEANAYDFIMALPDKYDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESV 565

  Fly   582 VQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINM 646
            ||.||:.||.||||||::||||.:..||.||.|.:|.|.|:|:|.:||..:|.|:::|.|..|:.
Frog   566 VQDALEKASAGRTTIVIAHRLSTVWTADVIVVIENGAVAEQGTHKELMEKKGIYHSLVTAQSIDA 630

  Fly   647 PDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEK 711
            .:..::.::.::..:|...:...|.:.|        ..|...||...|..:|:      |:.| |
Frog   631 AETDKQTETAQEMNRKPSLVKRLSSKIS--------TRSEHLEEEEEKEDVKE------ESLP-K 680

  Fly   712 PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS 776
            .:||    :||.|.|.||.|:::||::|:..|..:|||.:.|.:..|..:..|||...|...:.|
Frog   681 VSFF----KILNLNKSEWPYILIGTLAAIINGGAHPAFCIFFAKVSAVFSTNDPERIQREANLYS 741

  Fly   777 --WACLG-LAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARL 838
              :|.:| ::|||   .|||.::|..:|..||.|:|.|.|.||:.||:.||||:.||.|||:.||
Frog   742 IIFAVIGVISFLT---YFLQGFMFGRSGEVLTMRVRQMAFKAMLRQEMSWFDDKKNSTGALTTRL 803

  Fly   839 SGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAV 903
            :.:|..||.|.|..|..:.:.::....||.:|..|.|:|.||.||..|.|:.:.:||...::...
Frog   804 ATDASQIQMATGSRLGLIAENVACMGLSVIIAFVYGWELTLLILAMTPFIIVTGLLETSALTGFA 868

  Fly   904 VREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQAS 968
            .|:|:.::.|.:||.|::.|||||..|.||......|.|.:|:.....:::.:..|:..:..|:.
Frog   869 NRDKKELQVAGKIAAETVDNIRTVISLTRERAFEEMYAESLQKPYRNSQKRAQVYGICFALSQSF 933

  Fly   969 AFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILD 1033
            .:|:||....:||:::..|:...:::|.|...:.||:|.:.|||:|.|.:|.|..|...||.:.:
Frog   934 IYFSYAATFRFGGLMLELGRTNSEELILVFAIVTYGAMSVGQSLSFAPDYSKAKSAASHLFALFE 998

  Fly  1034 RKPKIQS--PMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGH 1095
            |:|.|.|  ..|....|       |:| |..|.:.|.||:|||..:|.||.:::..|||||.||.
Frog   999 REPAIDSYCQQGQKPET-------FQGSVELRKVSFNYPSRPDVPVLQGLSIKIQSGQTVAFVGS 1056

  Fly  1096 SGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGD 1160
            |||||||.||||||:|||.:|.:..|:.|.: .|.:..:|:::.||||||.||:.||||||||||
Frog  1057 SGCGKSTSVQLLQRFYDPYQGDVLFDNLDAK-CLNIQWLRSQIAIVSQEPVLFDCSIAENIAYGD 1120

  Fly  1161 NRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLD 1225
            |.|:|.|.||..|||:||.||||..||..|:|::|.:||||||||||||||||||||.||:||||
Frog  1121 NSRAVPMEEIQRAAKAANIHSFIEGLPEKYNTKVGGKGTQLSGGQKQRIAIARALVRKPKLLLLD 1185

  Fly  1226 EATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGG 1290
            |||||||.:||::||||||.|..|||||:||||||||||||||.|::||:::|.|||.||:::.|
Frog  1186 EATSALDNESEKIVQQALDQARQGRTCILIAHRLSTVQNADVIVVMKNGRIIELGNHQQLLAKRG 1250

  Fly  1291 IYAKLHKTQ 1299
            .|..|...|
Frog  1251 TYFDLVNAQ 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	523/1215 (43%)
		ABC_membrane	108..354	CDD:279056	78/245 (32%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	141/236 (60%)
		ABC_membrane	736..1006	CDD:279056	93/272 (34%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	150/239 (63%)
LOC100485969	XP_031758323.1	PTZ00265	103..1252	CDD:240339	518/1184 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930