Protein Alignment Mdr65 and abcb4

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001303643.1
• Gene: abcb4 / 100136865
• ZFINID: ZDB-GENE-080204-52
• Length: 1275
• Species: Danio rerio
• Alignment Length: 1313
• Identity: 551/1313 - (41%)
• Similarity: 804/1313 - (61%)
• Gaps: 62/1313 - (4%)

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            :::|....|.|...:||....|.||...||   :|||::...:|..:..|.||.......||.:|
Zfish    13 KKEENGDVSGEKNGKEEKEEKEKLEMVGPI---ELFRYADSIDILLMMLGLIMSMANGAVLPLMV 74

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVM 131
            |::.:.|...||..: .....|:...|.|        ...|.:|..|.:...::.|..:|...|:
Zfish    75 IVFGDMTDSFVDDTL-LDNLKNITLPPNF--------TFPETSNITLGEKMTTHAIYYSIMGFVV 130

  Fly   132 FISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKV 196
            .::....|..:.:.|.|||.::|...|.|:::|:|||.|:.........:.|||.||.:||.:|:
Zfish   131 LVAAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKL 195

  Fly   197 GHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAE 261
            |..:..:..||:.:.|.|:.||||||.:.:..||:.:....:.|.....|::||.:||.||.:||
Zfish   196 GMLIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAE 260

  Fly   262 EILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNL 326
            |:|||||||.:|||:|.|::||...|..|:.....|.....::......|:|:|.|.|||||..|
Zfish   261 EVLSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTL 325

  Fly   327 IIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLS 391
            |:      ..|||..:|:..||.:::||..:.:|:|.:::|::|||.|..:|::||...||:..|
Zfish   326 IL------GGEYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFS 384

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRF 456
            .:|..|:. ::|::||:::.||||||.:|.|..|:|:::.:|||:||||||||||||.:||||||
Zfish   385 EEGYKLDV-VKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRF 448

  Fly   457 YDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAG 521
            |||..|||.:|..|||..|::.||..|.||.||||||..|||:||.||:...||.|||.||.:|.
Zfish   449 YDPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREAN 513

  Fly   522 AHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL 586
            |:.||..||:.:.:::|:||:|:||||||||||||||::|||||||||||||||.:||..||.||
Zfish   514 AYNFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAAL 578

  Fly   587 DLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINM----P 647
            |....|||||||:||||.||.||.|....:|:::|.|:||:||..:|.|:::|     ||    .
Zfish   579 DKVRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLV-----NMQMFKS 638

  Fly   648 DEVEKEDSIEDTKQKSLALFEKSFETSPLN----FEKGQKNSVQFEEPIIKALIKDTNAQSAEAP 708
            .||.:|||.|      :.:.|||...|.:|    |.:..::..:.|            .:..|.|
Zfish   639 TEVAEEDSEE------MTMDEKSPSVSSMNERTLFRQKSRSGSEKE------------LKEEEKP 685

  Fly   709 PEK---PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALR 770
            .|:   ||.  :|..:|:|...||.|:::|.:.|...|.:.|||||||.:..|..||.|.....:
Zfish   686 TEEEKVPNV--SFLTVLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAEPDQNLVRQ 748

  Fly   771 RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALS 835
            |..:.|....|:..|:....|||.:.|..||..||.|:|...||||:.|::.|:||..||||||:
Zfish   749 RCDLYSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTKNSVGALT 813

  Fly   836 ARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMS 900
            .||:.:...:|||.|..|:.:.|.::|..:::.::..|.|:|.||.|:..||:..:..::.|:::
Zfish   814 TRLAADTAQVQGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAIQMKLLA 878

  Fly   901 NAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTM 965
            ...:::|:.:|:|.:||||:|.|:|||..|.||:.....|.|.:.......::|....|:..|..
Zfish   879 GHALKDKKELEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVFGLTFSFS 943

  Fly   966 QASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQ 1030
            ||..:||||....:|..|:.:..:.|:.:..|...::||:|.:.::.:|||.::.|.::...:..
Zfish   944 QAMIYFAYAGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLM 1008

  Fly  1031 ILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVG 1094
            :::|.|.|.:     .:....:.:.||| |.:..:.|:||:|||..:|.||.|.|.||||:||||
Zfish  1009 LINRAPAIDN-----SSEDGDKPDKFEGNVGFEHVYFKYPSRPDVPVLQGLKLRVKKGQTLALVG 1068

  Fly  1095 HSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYG 1159
            .|||||||.:|||:|:|||.:|.:.:|.:|.: .|.:..:|:::|||||||.||:.|:|||||||
Zfish  1069 SSGCGKSTTIQLLERFYDPQQGRVMLDDNDAK-QLNIHWLRSQIGIVSQEPVLFDCSLAENIAYG 1132

  Fly  1160 DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLL 1224
            ||.|.|...||:.|||:||.||||.:||..|.|:.|.:|||||||||||||||||::||||:|||
Zfish  1133 DNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLL 1197

  Fly  1225 DEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG 1289
            ||||||||.:||::||.|||.|..|||||::||||||:||||.|.|:|||.|||||.|.||:||.
Zfish  1198 DEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGTHQQLLSQQ 1262

  Fly  1290 GIYAKLHKTQKDH 1302
            |.|..|..:|..|
Zfish  1263 GAYYTLVTSQMSH 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	241/522 (46%)
		MdlB	711..1299	CDD:440747	260/591 (44%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	533/1257 (42%)
		MdlB	55..635	CDD:440747	259/600 (43%)