DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr65 and abcb4

DIOPT Version :9

Sequence 1:NP_476831.1 Gene:Mdr65 / 38726 FlyBaseID:FBgn0004513 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001303643.1 Gene:abcb4 / 100136865 ZFINID:ZDB-GENE-080204-52 Length:1275 Species:Danio rerio


Alignment Length:1313 Identity:551/1313 - (41%)
Similarity:804/1313 - (61%) Gaps:62/1313 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            :::|....|.|...:||....|.||...||   :|||::...:|..:..|.||.......||.:|
Zfish    13 KKEENGDVSGEKNGKEEKEEKEKLEMVGPI---ELFRYADSIDILLMMLGLIMSMANGAVLPLMV 74

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVM 131
            |::.:.|...||..: .....|:...|.|        ...|.:|..|.:...::.|..:|...|:
Zfish    75 IVFGDMTDSFVDDTL-LDNLKNITLPPNF--------TFPETSNITLGEKMTTHAIYYSIMGFVV 130

  Fly   132 FISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKV 196
            .::....|..:.:.|.|||.::|...|.|:::|:|||.|:.........:.|||.||.:||.:|:
Zfish   131 LVAAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKL 195

  Fly   197 GHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAE 261
            |..:..:..||:.:.|.|:.||||||.:.:..||:.:....:.|.....|::||.:||.||.:||
Zfish   196 GMLIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAE 260

  Fly   262 EILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNL 326
            |:|||||||.:|||:|.|::||...|..|:.....|.....::......|:|:|.|.|||||..|
Zfish   261 EVLSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTL 325

  Fly   327 IIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLS 391
            |:      ..|||..:|:..||.:::||..:.:|:|.:::|::|||.|..:|::||...||:..|
Zfish   326 IL------GGEYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFS 384

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRF 456
            .:|..|:. ::|::||:::.||||||.:|.|..|:|:::.:|||:||||||||||||.:||||||
Zfish   385 EEGYKLDV-VKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRF 448

  Fly   457 YDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAG 521
            |||..|||.:|..|||..|::.||..|.||.||||||..|||:||.||:...||.|||.||.:|.
Zfish   449 YDPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREAN 513

  Fly   522 AHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL 586
            |:.||..||:.:.:::|:||:|:||||||||||||||::|||||||||||||||.:||..||.||
Zfish   514 AYNFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAAL 578

  Fly   587 DLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINM----P 647
            |....|||||||:||||.||.||.|....:|:::|.|:||:||..:|.|:::|     ||    .
Zfish   579 DKVRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLV-----NMQMFKS 638

  Fly   648 DEVEKEDSIEDTKQKSLALFEKSFETSPLN----FEKGQKNSVQFEEPIIKALIKDTNAQSAEAP 708
            .||.:|||.|      :.:.|||...|.:|    |.:..::..:.|            .:..|.|
Zfish   639 TEVAEEDSEE------MTMDEKSPSVSSMNERTLFRQKSRSGSEKE------------LKEEEKP 685

  Fly   709 PEK---PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALR 770
            .|:   ||.  :|..:|:|...||.|:::|.:.|...|.:.|||||||.:..|..||.|.....:
Zfish   686 TEEEKVPNV--SFLTVLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAEPDQNLVRQ 748

  Fly   771 RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALS 835
            |..:.|....|:..|:....|||.:.|..||..||.|:|...||||:.|::.|:||..||||||:
Zfish   749 RCDLYSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTKNSVGALT 813

  Fly   836 ARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMS 900
            .||:.:...:|||.|..|:.:.|.::|..:::.::..|.|:|.||.|:..||:..:..::.|:::
Zfish   814 TRLAADTAQVQGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAIQMKLLA 878

  Fly   901 NAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTM 965
            ...:::|:.:|:|.:||||:|.|:|||..|.||:.....|.|.:.......::|....|:..|..
Zfish   879 GHALKDKKELEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVFGLTFSFS 943

  Fly   966 QASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQ 1030
            ||..:||||....:|..|:.:..:.|:.:..|...::||:|.:.::.:|||.::.|.::...:..
Zfish   944 QAMIYFAYAGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLM 1008

  Fly  1031 ILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVG 1094
            :::|.|.|.:     .:....:.:.||| |.:..:.|:||:|||..:|.||.|.|.||||:||||
Zfish  1009 LINRAPAIDN-----SSEDGDKPDKFEGNVGFEHVYFKYPSRPDVPVLQGLKLRVKKGQTLALVG 1068

  Fly  1095 HSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYG 1159
            .|||||||.:|||:|:|||.:|.:.:|.:|.: .|.:..:|:::|||||||.||:.|:|||||||
Zfish  1069 SSGCGKSTTIQLLERFYDPQQGRVMLDDNDAK-QLNIHWLRSQIGIVSQEPVLFDCSLAENIAYG 1132

  Fly  1160 DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLL 1224
            ||.|.|...||:.|||:||.||||.:||..|.|:.|.:|||||||||||||||||::||||:|||
Zfish  1133 DNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLL 1197

  Fly  1225 DEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG 1289
            ||||||||.:||::||.|||.|..|||||::||||||:||||.|.|:|||.|||||.|.||:||.
Zfish  1198 DEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGTHQQLLSQQ 1262

  Fly  1290 GIYAKLHKTQKDH 1302
            |.|..|..:|..|
Zfish  1263 GAYYTLVTSQMSH 1275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr65NP_476831.1 PTZ00265 91..1300 CDD:240339 524/1220 (43%)
ABC_membrane 108..354 CDD:279056 84/245 (34%)
ABC_MTABC3_MDL1_MDL2 405..642 CDD:213216 141/236 (60%)
ABC_membrane 736..1006 CDD:279056 91/269 (34%)
ABC_MTABC3_MDL1_MDL2 1059..1299 CDD:213216 149/239 (62%)
abcb4NP_001303643.1 PTZ00265 55..1266 CDD:240339 533/1257 (42%)
ABC_membrane 60..348 CDD:279056 98/302 (32%)
ABC_MTABC3_MDL1_MDL2 397..634 CDD:213216 142/241 (59%)
ABC_membrane 714..984 CDD:279056 91/269 (34%)
ABC_MTABC3_MDL1_MDL2 1035..1272 CDD:213216 148/237 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 96 1.000 Domainoid score I7260
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.860

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