DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr65 and abcb10

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	672	Identity:	228/672 - (33%)
Similarity:	357/672 - (53%)	Gaps:	94/672 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 LALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLA-KQ 727
            :||:..|.:::..:      .||..:|...|     |.|.|...|.|      ...::|||| .|
Zfish    84 VALYSTSTDSNQTS------KSVVNQESSAK-----TTADSLPVPSE------DVKKLLQLAHPQ 131

  Fly   728 EWCYLILGTISAVAVGFLYPAFAV------IFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLT 786
            .|      .::| |||||..:..|      ..|:....:.....||.   ::.|:..||   .||
Zfish   132 RW------RLTA-AVGFLVISSTVTMSAPFFLGKVIDTIYTSPTEDF---SSSLTSLCL---MLT 183

  Fly   787 GLVCFL--------QTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAV 843
            |:  ||        :.||...:|..:..::|...|::::.||:|:||  ....|.|..|||.:..
Zfish   184 GV--FLCGGAANAARVYLMQISGQQIVRKLRESLFSSILKQELGFFD--KTRTGELINRLSADTA 244

  Fly   844 DIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQ 908
            .:...:...||..:::|:...:.|.:.:|.:..||...|...|.|....::..:.:.:...|.:.
Zfish   245 IVGRCLTDNLSDGLRSLAQAGAGVGMMLYVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQD 309

  Fly   909 VIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY 973
            .:.||.::|.|.|:|:|||....:|...:::|::::..:..|.:::         .:.::.|:..
Zfish   310 ALAEATQLAEERISNLRTVRAFGKELTEVQKYSQKVDHIFELAKKE---------AVVSAGFYGV 365

  Fly   974 A--------VALCY-GGVLVSE-----GQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALI- 1023
            .        :::.| ||:|::.     |||        |..|:| :..:..|:|...:|.:.|:
Zfish   366 TGLSGNVIILSVLYKGGLLMASEAMTVGQL--------SSFLMY-AFWVGISIAGFSSFYSELMK 421

  Fly  1024 ---AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEV 1084
               ||.||::::||||:.....|.:..:     .|.:| :.:|.:.|.||||.|:.|...|.|.|
Zfish   422 GLGAGTRLWELIDRKPEFPLNEGLVLTS-----ELLKGELEFRNVSFAYPTRKDSPIFQDLSLHV 481

  Fly  1085 LKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFE 1149
            ..|..:|:||.||.|||:.|.||.|.||||.|.:.:|..||: ||....:|:.:|.|||||.||.
Zfish   482 PAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVDGHDIR-DLNPYWLRSHIGTVSQEPVLFS 545

  Fly  1150 RSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
            .||||||||| .:...|::.:|..||:.||||.||...|.||||.:|.:|..||||||||:||||
Zfish   546 CSIAENIAYGAPDPSQVTVEDIYRAAQIANAHDFIQEFPKGYDTVVGEKGVLLSGGQKQRVAIAR 610

  Fly  1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVE 1278
            ||::|||||||||||||||.::|.|||:||:....|||.::|||||||:|:||.:.|:...:|:|
Zfish   611 ALLKNPKILLLDEATSALDAENEFLVQEALERLMDGRTVLIIAHRLSTIQSADSVAVLDQHRVME 675

  Fly  1279 QGNHMQLISQG-GIYAKLHKTQ 1299
            .|:|.||::.. |::.||.:.|
Zfish   676 IGSHSQLLANDQGLFRKLMEKQ 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	228/672 (34%)
		ABC_membrane	108..354	CDD:279056
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216
		ABC_membrane	736..1006	CDD:279056	67/297 (23%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	127/241 (53%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	215/614 (35%)
		ABC_membrane	141..402	CDD:279056	63/288 (22%)
		P-loop_NTPase	457..697	CDD:304359	127/240 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910