Protein Alignment CG10226 and ABCC3

DIOPT Version :9

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_003777.2
• Gene: ABCC3 / 8714
• HGNCID: 54
• Length: 1527
• Species: Homo sapiens
• Alignment Length: 1370
• Identity: 315/1370 - (22%)
• Similarity: 568/1370 - (41%)
• Gaps: 256/1370 - (18%)

  Fly    33 QPMVSYTE------LFRYIAG------WDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERT 85
            |.::|:..      |.|:|:.      |.:||....|:.:.:|||:    :..|...:  |:.
Human   321 QDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLI----LQHYYHYI--FVT-- 377

  Fly    86 LGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRL 150
                            |.|..|                  ||:           ||.|     |.
Human   378 ----------------GVKFRT------------------GIM-----------GVIY-----RK 392

  Fly   151 ALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISV 215
            ||.:|..::|   .:|:.:.:..  |:.|   |.|..|            |..::.::....:.:
Human   393 ALVITNSVKR---ASTVGEIVNL--MSVD---AQRFMD------------LAPFLNLLWSAPLQI 437

  Fly   216 VLSFIYGWK----LALAIVFYIPLTLVVNSAVA----HYQGKLTGQEQSSYVRASSVVEEVIGAI 272
            :|:..:.|:    ..||.|.::.|.:.:|.|||    .:|.|....:.|..    .::.|::..|
Human   438 ILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRI----KLMSEILNGI 498

  Fly   273 RTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRD 337
            :.:..:..|.|...:.:.:.:..|:..:........:........|:....:.|     :..|.|
Human   499 KVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLW-----VYVYVD 558

  Fly   338 PSIPIDEREYTPAVVMIVISGII-VSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSK 401
            |:..:|..:   |.|.:.:..|: :..|.:.:   .:.....|..|...|...:.:..| ||.|.
Human   559 PNNVLDAEK---AFVSVSLFNILRLPLNMLPQ---LISNLTQASVSLKRIQQFLSQEEL-DPQSV 616

  Fly   402 AGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFY 466
            ..|.::.|.  |:......|.: |::....|..|::.|.:|..||:|||.|||||:.:..|....
Human   617 ERKTISPGY--AITIHSGTFTW-AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEM 678

  Fly   467 DPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGK---PEATQKEVEDAAKA 528
            :.:.|:|.:.|             ::|.|.|:..:...::.||:..||   |:..|:.:|..|..
Human   679 EKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL 730

  Fly   529 ANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLV-- 591
            |:    :..|..|..|:|.|||:.||||||||:::|||:.....|.|||:..||:|.|..|.:
Human   731 AD----LEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFD 791

  Fly   592 -QAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDD 655
             ....:....|:|.::|:|.:|.:.....|:.:.:|:..|.|.:..|::..|.:...:..::.|:
Human   792 HVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE 856

  Fly   656 SAEELLNELE--EVAEIKERKMSYE-VEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEID 717
            ....|.:...  |.||.||..:..: :..:...|.|..|:.....:| |:.|:.|::....|...
Human   857 DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQF-MRQLSALSSDGEGQGRP 920

  Fly   718 DPR---VPSANFISTFFRILGWARPE-------------WSFL-IIG-----AICAGLYGVTMPV 760
            .||   .||.....|..:..|....|             |.:. .:|     |||....|.:.
Human   921 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-- 983

  Fly   761 FSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLA-------GVWLTT 818
             :.:.|.::  |:..|::.:.:...:...:.|.:..|.|:   :|.|...||       |:....
Human   984 -AAIGANVW--LSAWTNDAMADSRQNNTSLRLGVYAALGI---LQGFLVMLAAMAMAAGGIQAAR 1042

  Fly   819 RMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAF 883
            .:........:.....:||...:  |.:....|.|...|...:...:..::.:|.|.|.:
Human  1043 VLHQALLHNKIRSPQSFFDTTPS--GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST----- 1100

  Fly   884 PYSWELALICLSTSPFMVASI------VFEARFGEKSALKEKEVLEETSRIA-----TETITQIR 937
                 |.:|..||..|.|..:      ....||...::.:.|. ||..||..     :||:|...
Human  1101 -----LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKR-LESVSRSPIYSHFSETVTGAS 1159

  Fly   938 TVAGLRREEELIKIYDKEVERYRHQ----ILSRLKWRGL-VNSLGKSLMFFGYAVTLTYGGHMCA 997
            .:....|..:...|.|.:|:..:..    |:|. :|..: |..:|..::.|.
Human  1160 VIRAYNRSRDFEIISDTKVDANQRSCYPYIISN-RWLSIGVEFVGNCVVLFA------------- 1210

  Fly   998 DGKIKFETIMKIS-NTMLYGLFILAQSLAFTPAFN----------AALLSANRMYEIIDRKPQIQ 1051
               ..|..|.:.| |..|.||.: :.||..|.|.|          :.:::..|:.|.  .|.:.:
Human  1211 ---ALFAVIGRSSLNPGLVGLSV-SYSLQVTFALNWMIRMMSDLESNIVAVERVKEY--SKTETE 1269

  Fly  1052 SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIK-VLQNFNLDINQGQTVALVGASGS 1115
            :|...|..:...|...:..     |.:|  |:|...||.:. ||::.:|.::.|:.|.:||.:|:
Human  1270 APWVVEGSRPPEGWPPRGE-----VEFR--NYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGA 1327

  Fly  1116 GKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIG-YGDTS 1179
            |||:....|.|..:..:|:|.||..:: .|:.|..||.:|.|:.|:|.||..::..|:. :|..|
Human  1328 GKSSMTLCLFRILEAAKGEIRIDGLNV-ADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1391

  Fly  1180 RQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEA 1244
            .    :.|..|.::::.|.|:.|.||..|......|..||.||:|.:.:|||::|..:||:||||
Human  1392 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEA 1452

  Fly  1245 TSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIY 1309
            |:|:|.:::.::|..:.:.....|.:.|||||:||.:...:.|:..|.:.|..|.:.|:|..||:
Human  1453 TAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517

  Fly  1310 SKLYR 1314
            ..:.|
Human  1518 YGMAR 1522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	301/1305 (23%)
		ABC_membrane	<147..333	CDD:279056	32/193 (17%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	70/240 (29%)
		ABC_membrane	749..1019	CDD:279056	56/293 (19%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	81/241 (34%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	315/1370 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	910..932		6/21 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910