DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10226 and ABCB11

DIOPT Version :9

Sequence 1:NP_648040.1 Gene:CG10226 / 38725 FlyBaseID:FBgn0035695 Length:1320 Species:Drosophila melanogaster
Sequence 2:XP_011510379.1 Gene:ABCB11 / 8647 HGNCID:42 Length:1355 Species:Homo sapiens


Alignment Length:1320 Identity:498/1320 - (37%)
Similarity:777/1320 - (58%) Gaps:67/1320 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KKKKTKEKAQ---PMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERT 85
            ||.:.:::.:   ..|.:.:|||:.:..|..::..|.:.|||..:..|..::::..:..:||:..
Human    64 KKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYD 128

  Fly    86 L--------GQGTSSVTIGLSLFGGGKILTNASYEENMQ--------ELRKDSVSFGILMTLNTL 134
            :        |:...:.||         :.||:|..:||.        .:..:.:.|........:
Human   129 VELQELQIPGKACVNNTI---------VWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAV 184

  Fly   135 LMLFSGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAE 199
            .:|.:|...:..:...|.:...:||:.:|:..:|.||||.|.........|.:|::.||...||:
Human   185 AVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIAD 249

  Fly   200 NLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSV 264
            .:..:::.|...|...:|.|..||||.|.|:...||..:..:.:.....|.|..|..:|.:|..|
Human   250 QMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVV 314

  Fly   265 VEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGA 329
            .:|||.::|||.|||||:.|..||:..|..|.:.|..||...|.....:..::|:..|.:||||:
Human   315 ADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGS 379

  Fly   330 NLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTS 394
            .|:|         ||.||||..::.:...:||.|..:...||.||.||..|.:|::|.:.|||..
Human   380 TLVL---------DEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKP 435

  Fly   395 LIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCI 459
            :||.:|:.|..|: .:||.:||.:|.|.||:|.:|.:|..||:|::.|:..|||||||.||||.:
Human   436 IIDCMSEDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTAL 499

  Fly   460 QLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVED 524
            ||:||||||..|.|.:||.|:|..||:|||..|.:|.||||||..:|.||||:|:.:||.:::..
Human   500 QLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQ 564

  Fly   525 AAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEK 589
            |||.|||::||:.|.:.:||.:.|.|.|:||||:||:|||||||:.|||||||.||||||..||.
Human   565 AAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEA 629

  Fly   590 LVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYD 654
            :||..|.|...|.|.:.|:||||.:|.|..|:..|:|.|||:||||||::.:|.|..:||:.|..
Human   630 MVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG 694

  Fly   655 DSAEELLNELEEVAEIKERKM---SYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANI----TM 712
            :.|   ||| |::.:..|..|   ::....||...|.||....|:....:.:...||.:    |.
Human   695 NQA---LNE-EDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTY 755

  Fly   713 NQEIDDPRVPSANFI--STFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKP 775
            .::..|..:|....:  :...|||.::.|||.::::|::.|.:.|...|:::.:.:::.|:.:.|
Human   756 EEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIP 820

  Fly   776 TDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKE 840
            ..||...|...:.::.:.:|..:....::|.:.|..:|..||.|:|...||.::.|::.|||...
Human   821 DKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLR 885

  Fly   841 NSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIV 905
            ||.|||:.||:.||:.||||.|..:..|:.:|||...::.|||.:||:|:|:.|...||:..|..
Human   886 NSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGA 950

  Fly   906 FEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWR 970
            .:.|.....|.::|:.||...:|..|.::.||||||:.:|...|:..:.|:|:.....:.:....
Human   951 TQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIY 1015

  Fly   971 GLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALL 1035
            |...:..:.:||...:.:..|||::.::..:.|..:.::.:.::.....|.::.::||::..|.:
Human  1016 GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKI 1080

  Fly  1036 SANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLD 1100
            ||.|.::::||:|.|..         .|....|.:..|..:.:....|:|||||..:||...::.
Human  1081 SAARFFQLLDRQPPISV---------YNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1136

  Fly  1101 INQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHD---MDLKTLRRRLGIVSQEP 1162
            |:.|||:|.||:||.||||.:|||.|:||||:||::||    .||   ::::.||..:|||||||
Human  1137 ISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID----GHDSKKVNVQFLRSNIGIVSQEP 1197

  Fly  1163 SLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIA 1227
            .||..||.|||.|||.::::||:::|.|||.|..|:|:||||.:|:|.:||:|:|||.|:|||||
Human  1198 VLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIA 1262

  Fly  1228 IARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGK 1292
            ||||:||:||||||||||||||.:||:.||.|||.|..|||||||||||||||||::|.|:..|.
Human  1263 IARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGV 1327

  Fly  1293 IVEQGSHSQLLAKNGIYSKL 1312
            ::|:|:|.:|:|:.|.|.||
Human  1328 VIEKGTHEELMAQKGAYYKL 1347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10226NP_648040.1 PTZ00265 81..1311 CDD:240339 484/1257 (39%)
ABC_membrane <147..333 CDD:279056 61/185 (33%)
ABC_MTABC3_MDL1_MDL2 414..649 CDD:213216 128/234 (55%)
ABC_membrane 749..1019 CDD:279056 75/269 (28%)
ABC_MTABC3_MDL1_MDL2 1076..1316 CDD:213216 138/240 (58%)
ABCB11XP_011510379.1 PTZ00265 52..1348 CDD:240339 498/1320 (38%)
ABC_membrane 101..405 CDD:279056 87/321 (27%)
ABC_MTABC3_MDL1_MDL2 454..691 CDD:213216 130/236 (55%)
ABC_membrane 794..1043 CDD:279056 74/248 (30%)
ABC_MTABC3_MDL1_MDL2 1112..1351 CDD:213216 138/240 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 207 1.000 Domainoid score I2881
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2081
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.780

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