DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and STE6

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_012713.1	Gene:	STE6 / 853671	SGDID:	S000001692	Length:	1290	Species:	Saccharomyces cerevisiae

Alignment Length:	1371	Identity:	357/1371 - (26%)
Similarity:	614/1371 - (44%)	Gaps:	187/1371 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KKTKEKAQPMVSYTELFRYI-AGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQG 89
            |.||        :..:|||: ...||.:|:...:......||..|..::
Yeast     7 KTTK--------HYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSIL---------------- 47

  Fly    90 TSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKL 154
            |..|...||:|     :.|.|::....:|.:.|::...|...:..:|..|    :.::..:..:.
Yeast    48 TGRVFDLLSVF-----VANGSHQGLYSQLVQRSMAVMALGAASVPVMWLS----LTSWMHIGERQ 103

  Fly   155 TVRMRREFFKATLRQE-IGWHD-MAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVL 217
            ..|:|.:..:|.|.:: :.|:| ..|......:|...:|::||..||......:.:..:...:..
Yeast   104 GFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGT 168

  Fly   218 SFIYGWKLALAIVFYIPLT---LVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFG 279
            ||.|.|.|.|.|:...|:.   .||.|.:.|...:   :|.|...:|:.::...:.|.:.|..:.
Yeast   169 SFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSE---KENSETSKAAQLLTWSMNAAQLVRLYC 230

  Fly   280 GERSESLRYDSLLKPA----LKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSI 340
            .:|.|..::..::...    :|:..:..|.:|:. ..:...:|:.|   ||:|:.:|   :...:
Yeast   231 TQRLERKKFKEIILNCNTFFIKSCFFVAANAGIL-RFLTLTMFVQG---FWFGSAMI---KKGKL 288

  Fly   341 PIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSK--AG 403
            .|::       |:......|:..:.::.|...:........:...|:.::...|..:||:|  |.
Yeast   289 NIND-------VITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKTVAH 346

  Fly   404 KI-LNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYD 467
            :. |:|.... :.|.:|.|.||:|....||:.:::....||...:||.||.||||...||.||||
Yeast   347 QFPLDYATSD-LTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYD 410

  Fly   468 PVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKE----------V 522
            ...|.:.::|.:::..:.|.|..||.||.|...||..::.:||..|..::.:..          :
Yeast   411 GYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLI 475

  Fly   523 EDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHS 587
            :||.:.|....||:.|..|.:|.|...||.|||||:||:|||||.|:...||.||||.||||...
Yeast   476 KDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVH 540

  Fly   588 EKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELM-----KLEGFYHKM 647
            ..|:..|:....||:||::::|.||.|.....:..::.|:.||.||..||:     ....:||..
Yeast   541 RNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQ 605

  Fly   648 VTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLG--------------------------- 685
               :.|.|:...:..|.||.:.......:.::|..:||
Yeast   606 ---NDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNV 667

  Fly   686 -TRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAI 749
             ||...|. |:|..:.:|......:.|..|.:        :.|....|::...|.: ..||:|.:
Yeast   668 RTRRVKVE-EENIGYALKQQKNTESSTGPQLL--------SIIQIIKRMIKSIRYK-KILILGLL 722

  Fly   750 CAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAA--GVVCYIQTFFFNLA 812
            |:.:.|.|.||||...:.|...:...||.:............||:|:||  |:..:.:.|..:..
Yeast   723 CSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCC 787

  Fly   813 GVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFIC 877
            ..:....:|::....:..:.|.||..:.|....:||.:..|...::..:    |..:.|.|:|:.
Yeast   788 SEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLV----SEFLSAMTSFVT 848

  Fly   878 SIAI----AFPYSWELALICLSTSPFMVASIVFEARFG---EKSALKEKEVLEETSRIATETITQ 935
            ...|    |....|:|:|:|:|..|.:   |:|.|.:|   :|.....|..:.:......:.:|.
Yeast   849 VSTIGLIWALVSGWKLSLVCISMFPLI---IIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTN 910

  Fly   936 IRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGK 1000
            |:|:..|:.|......|        |.:  ::|.:.:.:   |..:..|:.:::|....||....
Yeast   911 IKTIKCLQAEFHFQLTY--------HDL--KIKMQQIAS---KRAIATGFGISMTNMIVMCIQAI 962

  Fly  1001 I-----KFETIMKISNTMLYGLFILAQSLAFT-----------PAFNAALLSANRMYEIIDRKPQ 1049
            |     |...|.:.::..::..|.|   |.||           |..:....:|:.:|.|:|.|
Yeast   963 IYYYGLKLVMIHEYTSKEMFTTFTL---LLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEK-- 1022

  Fly  1050 IQSPESFEIQQNG------NGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVA 1108
               ..:.|::.|.      .|..|.....:..||.:.|.|:|||.|...|.:|.|.|:..|||:.
Yeast  1023 ---HNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLG 1084

  Fly  1109 LVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNI 1173
            ::|.||:||||.|.||.:.|:.:.|||.||...: :|.:|.:||:.:.:|.|:|.||..:|.||:
Yeast  1085 IIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDV-NDWNLTSLRKEISVVEQKPLLFNGTIRDNL 1148

  Fly  1174 GYG--DTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNP 1236
            .||  |...::.|   .:|.|....|:|::|.|...||.:.:  |.|||||.||:.||||::|..
Yeast  1149 TYGLQDEILEIEM---YDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQRLCIARALLRKS 1208

  Fly  1237 KILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQ 1301
            |||:|||.|||||..|..::.:.:.........:||.|....:::.|.|.|::.||:||:|:...
Yeast  1209 KILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDT 1273

  Fly  1302 LLAKNG 1307
            |....|
Yeast  1274 LYNNRG 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	345/1315 (26%)
		ABC_membrane	<147..333	CDD:279056	40/194 (21%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	91/249 (37%)
		ABC_membrane	749..1019	CDD:279056	59/283 (21%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	93/234 (40%)
STE6	NP_012713.1	MdlB	24..605	CDD:224055	161/623 (26%)
STE6	NP_012713.1	MdlB	702..1289	CDD:224055	172/613 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm46468
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
TreeFam	1	0.960	-	-
	9	8.720