DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCC11

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1430	Identity:	337/1430 - (23%)
Similarity:	576/1430 - (40%)	Gaps:	334/1430 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVT 94
            |||..::......|....:|.|:.:...:|:.|..::....|:.||       |..||.....|.
Human   147 EKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS-------EEQLGNVVHGVG 204

  Fly    95 IGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLML-FSGVYYVDAFNRL-----ALK 153
            :..:||              :.|..| |:||.....:|....: |.......||.:|     .:.
Human   205 LCFALF--------------LSECVK-SLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH 254

  Fly   154 LTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCD--VIISVV 216
            :|......||                       |.::..:..|:.  .|..|.|.|.  ||.|:.
Human   255 ITSGEAISFF-----------------------TGDVNYLFEGVC--YGPLVLITCASLVICSIS 294

  Fly   217 LSFIYGWKLALAIVFYI---PLTLVVNSAVA---HYQGKLTGQEQSSYVRASSVVEEVIGAIRTV 275
            ..||.|:...:||:.|:   ||.:.:.....   |:..:::.|.    :|.:|   ||:..|:.:
Human   295 SYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQR----IRVTS---EVLTCIKLI 352

  Fly   276 VAFGGERS-----ESLRYD--SLLKPALKAGKWKGAFSGLSDTVMKAMLFI--TGAGSFWYGANL 331
            ..:..|:.     |.||..  .||:..           ||..::....|||  |.|.:.|
Human   353 KMYTWEKPFAKIIEDLRRKERKLLEKC-----------GLVQSLTSITLFIIPTVATAVW----- 401

  Fly   332 ILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAM--ARGSASAIL------- 387
            :|.:....:.:     |.::...:::.:     .:.|.|.|....|:  ...|.||::
Human   402 VLIHTSLKLKL-----TASMAFSMLASL-----NLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFL 456

  Fly   388 ---DVIDRTSLIDPLSKA--------------GKILNYGL---------KGAVEFRDVFFRYPAR 426
               .|....:|.|| |||              ..|:|..|         :|....||..  .|..
Human   457 QESPVFYVQTLQDP-SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL--GPEE 518

  Fly   427 EDVIV---LRGLNVVVEEGQTVALVGPSGCGKSTCIQ-LLQRFYDPVFGQVLLDGEDVRKYNIKW 487
            |...:   |..:|:||.:|..:.:.|.:|.|||:.:. :|:..:       ||:|.       ..
Human   519 EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH-------LLEGS-------VG 569

  Fly   488 LRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHD---FIIALH---------- 539
            ::.::|.|.|:..:..|:|.|||..|                .|:|   ::..||
Human   570 VQGSLAYVPQQAWIVSGNIRENILMG----------------GAYDKARYLQVLHCCSLNRDLEL 618

  Fly   540 --KGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEK-LVQAALDKACKG 601
              .|..|:|.|:|:.|||||:|||::|||:....:|.|||:..||:|.|..| :.:..:.|..:|
Human   619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683

  Fly   602 RTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMV-TVHSYDDSAEELLNELE 665
            :|.::|:|:|..:....:|:.:||||..|.|||.|||:.:|.|.::: .:|.     |...:.|:
Human   684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHK-----EATSDMLQ 743

  Fly   666 EVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLA------NITMNQEIDDPRVPSA 724
            :.|:|.|:.   :||...|.|     |||       ::|||.|      .:|..:|:::..
Human   744 DTAKIAEKP---KVESQALAT-----SLE-------ESLNGNAGNVPEHQLTQEEEMEEGS---- 789

  Fly   725 NFISTFFRILGWARPEWSFLIIGAI---CAGLYGVTMPVFSVVLA------------------EL 768
                     |.|..........|..   |...:.|.:.||..:.:                  |.
Human   790 ---------LSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRES 845

  Fly   769 YGSLAKPTDEEVLEQSASMAIISLVIGI-AAGVVCY------IQTFFFNLAGVWLTTRMRSKTFR 826
            .|::|   |...:..:..::...||.|: |..::|.      |.|.....|...|..::.:|.||
Human   846 NGTMA---DLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFR 907

  Fly   827 CIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTN-----------FICSIA 880
            |    .|.:||  ...||.|....:||...        |..::..|:.           .:..::
Human   908 C----PMSFFD--TIPIGRLLNCFAGDLEQ--------LDQLLPIFSEQFLVLSLMVIAVLLIVS 958

  Fly   881 IAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSR--IATETITQIRTVAGLR 943
            :..||      |.|..:..||...::...|  |.|:...:.||..||  :.:..:..::.::.:.
Human   959 VLSPY------ILLMGAIIMVICFIYYMMF--KKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1015

  Fly   944 ---REEELIKIYDKEVE---RYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIK 1002
               :.|:.|..:.:..:   .|....||..:|..|...:..:|:....|:.:.:|
Human  1016 VYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFG---------- 1070

  Fly  1003 FETIMKISNTMLYGLFILAQS--LAFTPAFNAAL---LSANRMYEIIDRKPQIQSPESFEIQQNG 1062
                  ||:|. |...::|.:  |....:|.|..   |.....:..::|..|.......|...:.
Human  1071 ------ISSTP-YSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1128

  Fly  1063 NGTAYKTNVVQQG-VSYRGLNFSY-PSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLM 1125
            .||:......|.| :.::..:..| .:.|  .||...||.|...:.|.:||.:|||||:....|.
Human  1129 EGTSCPQGWPQHGEIIFQDYHMKYRDNTP--TVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALF 1191

  Fly  1126 RYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEA 1190
            |..:|..|:||||...| ..:.|:.||.:|.::.|:|.|...:|..|:...|....   |||.:|
Human  1192 RLVEPMAGRILIDGVDI-CSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTD---QQIWDA 1252

  Fly  1191 AKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERV 1255
            .:.....:.|...|.:..|.:...|...|.|::|.:.||||::||.||:|:||||:::|.:::.:
Human  1253 LERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1317

  Fly  1256 VQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNG-IYSKLYRCQTKA 1319
            :|:.:..|..|.|.:|||||::|:.|.:.|.|:..||:||......|..|.| :::.|....|.:
Human  1318 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1382

Fly 1320 1319
Human 1383 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	324/1369 (24%)
		ABC_membrane	<147..333	CDD:279056	43/207 (21%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	76/255 (30%)
		ABC_membrane	749..1019	CDD:279056	58/316 (18%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	80/241 (33%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	335/1419 (24%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910