DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB11

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001322407.1	Gene:	ABCB11 / 839353	AraportID:	AT1G02520	Length:	1278	Species:	Arabidopsis thaliana

Alignment Length:	1328	Identity:	480/1328 - (36%)
Similarity:	740/1328 - (55%)	Gaps:	109/1328 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87
            :|::|::|||. .|.:.:||.:....|.|:::.|.:.|....:..|...:::.:|:..|
plant    29 KKEEKSEEKAN-TVPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGDLIDSF------ 86

  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLAL 152
                           ||   |.:.::.:..:.|..:.| :.:.|.||     |.    ||.::|.
plant    87 ---------------GK---NQNNKDIVDVVSKVCLKF-VYLGLGTL-----GA----AFLQVAC 123

  Fly   153 ------KLTVRMRREFFKATLRQEIGWHDMAKDQNFAV-RITDNMEKIRSGIAENLGHYVEIMCD 210
                  :...|:|..:.|..|||:||:.|:..:....| |::.:...|:..:.|.:|.:::::..
plant   124 WMITGERQAARIRSTYLKTILRQDIGFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVST 188

  Fly   211 VIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTV 275
            .:...||:||.||.|.|.::..|||..:..:|:|....:.:.:.|::|.:|::|||:.||:||||
plant   189 FVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATVVEQTIGSIRTV 253

  Fly   276 VAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSI 340
            .:|.||:.....|...:..|.|:...:|..:||...||..:.|.:.|.:.|:|..:||
plant   254 ASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGGKMIL------- 311

  Fly   341 PIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKI 405
               |:.||...|:.||..::..:..:.:|||.:..||..:.:|..:.:.|.|..|||.....||:
plant   312 ---EKGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKV 373

  Fly   406 LNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVF 470
            |. .::|.:|.:||.|.||||.|..:..|.::.:..|.|.||||.||.||||.|.|::|||||..
plant   374 LE-DIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIERFYDPKS 437

  Fly   471 GQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFI 535
            |.||:||.:::::.:||:||.|.:|.||||||..||.|||.:||..||.:|::.|.:.|||..||
plant   438 GAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELANAAKFI 502

  Fly   536 IALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACK 600
            ..|.:|.||.:.|.|.||||||:||||||||:::.|:||||||||||||..||::||.|||:...
plant   503 DKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMV 567

  Fly   601 GRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMK-LEGFYHKMVTVHSYDDSAEELLNEL 664
            .|||::|:||||.:|:|..|..|..||.||:|:|.||:| .||.|.:::.:...:...:  .:||
plant   568 NRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVK--TSEL 630

  Fly   665 EEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLA----------------NITMN 713
            ...:..:...:...:|    ||.    |:..::.....|:.||.                ..|.:
plant   631 SSGSSFRNSNLKKSME----GTS----SVGNSSRHHSLNVLGLTTGLDLGSHSQRAGQDETGTAS 687

  Fly   714 QEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDE 778
            || ..|:|       :..||....:||...|::|.:.|.:.|...|:|.::::.:..:..||. .
plant   688 QE-PLPKV-------SLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFFKPA-H 743

  Fly   779 EVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSI 843
            |:...|...|||.:.:|:.:.:|...|.:.|.:||..|..|:||..|...::.|:.|||..:||.
plant   744 ELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNSS 808

  Fly   844 GALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEA 908
            |.:.||||.||..::..:|..||..:|...:....:.|||..|||||||.|...|.:..:...:.
plant   809 GTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGINGFVQV 873

  Fly   909 RFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLV 973
            :|.:..:...|...||.|::|.:.:..|||||....||:::::|.|:.|   ..|...:| :|.:
plant   874 KFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCE---GPIKDGIK-QGFI 934

  Fly   974 NSLGKSLMFF----GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAAL 1034
            :.||....||    .||.:...|..:..|||..|..:.::...:......::||..|.|..:.|.
plant   935 SGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGISQSSTFAPDSSKAK 999

  Fly  1035 LSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNL 1099
            ::|..::.|||||.:|.|.:.       .||..:.  |:..:..|.|:|:||:||.|::.::..|
plant  1000 VAAASIFAIIDRKSKIDSSDE-------TGTVLEN--VKGDIELRHLSFTYPARPDIQIFRDLCL 1055

  Fly  1100 DINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSL 1164
            .|..|:||||||.|||||||.:.||.|:||||.|.|.:|...: ..:.||.||:::|:|.|||.|
plant  1056 TIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVEL-KKLQLKWLRQQMGLVGQEPVL 1119

  Fly  1165 FEKSIADNIGYGDTSRQVPMQ-QIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAI 1228
            |..:|..||.||..|.:...: :||.||::||||:||.|:...||||:|.:|.|||||||||:||
plant  1120 FNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQKQRVAI 1184

  Fly  1229 ARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKI 1293
            |||:|:.||||||||||||||.:||||||.|||.....||.||:|||||||:||:||.|::.|.|
plant  1185 ARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVI 1249

  Fly  1294 VEQGSHSQLL-AKNGIYSKLYRCQTKAS 1320
            .|:|:|..|: .:.|:|:.|.:....||
plant  1250 AEKGTHETLIKIEGGVYASLVQLHMTAS 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	463/1259 (37%)
		ABC_membrane	<147..333	CDD:279056	56/192 (29%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	126/235 (54%)
		ABC_membrane	749..1019	CDD:279056	81/273 (30%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	131/241 (54%)
ABCB11	NP_001322407.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790