DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB12

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_171754.1	Gene:	ABCB12 / 839282	AraportID:	AT1G02530	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1328	Identity:	467/1328 - (35%)
Similarity:	731/1328 - (55%)	Gaps:	109/1328 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTS 91
            ||.|||:.:..| :||.:...:|..:::.|.:.|....:..|:..:::.:|:..|
plant    20 KTDEKAKTVPLY-KLFAFADSFDVFLMICGSLGAIGNGVCLPLMTLLFGDLIDSF---------- 73

  Fly    92 SVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGV-YYVDAFNRLALKLT 155
                       ||   |.:.::.:..:.|..:.| :.:.|..|...|..| .::....|.|.|:
plant    74 -----------GK---NQNNKDIVDVVSKVCLKF-VYLGLGRLGAAFLQVACWMITGERQAAKI- 122

  Fly   156 VRMRREFFKATLRQEIGWHDMAKDQNFAV-RITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSF 219
               |..:.|..|||:||:.|:..:....| |::.:...|:..:.|.:|.:::::...:....|:|
plant   123 ---RSNYLKTILRQDIGFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAF 184

  Fly   220 IYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSE 284
            ..||.|.|.::..||...:..:|:|....:.:.:.|::|.:|::|||:.||:||||.:|.||:..
plant   185 AKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQA 249

  Fly   285 SLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREYTP 349
            ...|...:..|.|:...:|..:||...||..:.|.:.|.:.|:|..:||          |:.||.
plant   250 INSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMIL----------EKGYTG 304

  Fly   350 AVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAV 414
            ..|:.||..::..:..:.:|||.:..||..:.:|..:.:.|.|..|||.....||:|. .::|.:
plant   305 GSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLG-DIRGDI 368

  Fly   415 EFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGED 479
            |.:||.|.||||.|..:..|.::.:..|.|.||||.||.||||.|.|::|||||..|:||:||.:
plant   369 ELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGIN 433

  Fly   480 VRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDT 544
            ::::.:||:||.|.:|.||||||..||.|||.:||..||.:|::.|.:.|||..||..|.:|.||
plant   434 LKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDT 498

  Fly   545 DISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSH 609
            .:.|.|.||||||:||||||||:::.|::|||||||||||..||::||.|||:....|||:||:|
plant   499 KVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAH 563

  Fly   610 RLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERK 674
            |||.:|:|..|..|.:||.||:|:|.||:|               ||    :....::...:|..
plant   564 RLSTVRNADMIAVIHSGKMVEKGSHSELLK---------------DS----VGAYSQLIRCQEIN 609

  Fly   675 MSYEVEPYQLGT----RNSIVSLEKNAEFQMKNLNGLANITMNQEID-------------DPRVP 722
            ..::.:|..:.:    |||.:::.:.........:...|.:.:..::             ..||.
plant   610 KGHDAKPSDMASGSSFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLGLFAGLDLGSGSQRVG 674

  Fly   723 SANFIST---------FFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDE 778
            .....:|         ..||....:||...|::|.:.|.:.|...|:|.::::.:..:..||.|
plant   675 QEETGTTSQEPLRKVSLTRIAALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAFFKPAD- 738

  Fly   779 EVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSI 843
            ::.:.|...|||.:.:|:.:.:|...|.:.|.:||..|..|::|..|...::.|:.|||..|||.
plant   739 QLKKDSRFWAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSS 803

  Fly   844 GALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEA 908
            |.:.||||.|||.::..:|..||..:|...:....:.|||..|||||||.|...|.:..:...:.
plant   804 GTMGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQV 868

  Fly   909 RFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLV 973
            :|.:..:...|...||.|::|.:.:..|||||....||:::::|:|:.|   ..|...:| :|.:
plant   869 KFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYNKQCE---GPIKDGVK-QGFI 929

  Fly   974 NSLGKSLMFF----GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAAL 1034
            :.||....||    .||.:......:..|||..|..:.::...:......::||..|.|..:.|.
plant   930 SGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAPDSSKAK 994

  Fly  1035 LSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNL 1099
            ::|..::.|||||.:|.|.:.       .||..:.  |:..:..|.|:|:||:||.|::.::..|
plant   995 VAAASIFAIIDRKSKIDSSDE-------TGTVLEN--VKGDIELRHLSFTYPARPGIQIFRDLCL 1050

  Fly  1100 DINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSL 1164
            .|..|:||||||.|||||||.:.||.|:||||.|:|.:|...: ..:.||.||:::|:|.|||.|
plant  1051 TIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVEL-KKLQLKWLRQQMGLVGQEPVL 1114

  Fly  1165 FEKSIADNIGYGDTSRQVPMQ-QIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAI 1228
            |..:|..||.||..|.:...: :||.||::||||:||.|:...||||:|.||.|||||||||:||
plant  1115 FNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAI 1179

  Fly  1229 ARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKI 1293
            |||:|:.||||||||||||||.:|||:||.|||.....||.:|:|||||||:||:||.:::.|.|
plant  1180 ARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAHRLSTIKNADVIAIVKNGVI 1244

  Fly  1294 VEQGSHSQLL-AKNGIYSKLYRCQTKAS 1320
            .|.|:|..|: ...|:|:.|.:....||
plant  1245 AENGTHETLIKIDGGVYASLVQLHMTAS 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	451/1263 (36%)
		ABC_membrane	<147..333	CDD:279056	53/186 (28%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	123/234 (53%)
		ABC_membrane	749..1019	CDD:279056	81/273 (30%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	129/241 (54%)
ABCB12	NP_171754.1	PTZ00265	3..1267	CDD:240339	465/1321 (35%)
		ABC_membrane	50..303	CDD:279056	69/291 (24%)
		ABC_MTABC3_MDL1_MDL2	368..606	CDD:213216	125/256 (49%)
		ABC_membrane	709..978	CDD:279056	81/273 (30%)
		ABC_MTABC3_MDL1_MDL2	1027..1267	CDD:213216	129/240 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790