DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and Abcb11

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_113948.1	Gene:	Abcb11 / 83569	RGDID:	619930	Length:	1321	Species:	Rattus norvegicus

Alignment Length:	1323	Identity:	498/1323 - (37%)
Similarity:	775/1323 - (58%)	Gaps:	73/1323 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KKKKTKEKAQP---MVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERT 85
            ||.:.::|.:.   .|.:.||||:.:..|..::|.|.|.|.|..:..|..::::..:..:||:..
  Rat    30 KKSRLQDKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYD 94

  Fly    86 LGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVY-----YVD 145
            :.:....:. |.:......:..|:|:.:||    .:....| |:.:.:.::.|||:|     .|.
  Rat    95 IERQELEIP-GKACVNNTIVWINSSFHQNM----TNGTVCG-LVDIESEMIKFSGIYAGVGMTVL 153

  Fly   146 AFNRLALKLTV--------RMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLG 202
            ......::|.|        |||:.:|:..:|.||||.|.........|..|::|||...||:.|.
  Rat   154 ILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLA 218

  Fly   203 HYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEE 267
            |:::.|...:..::|.|..||||.|.|:...||..:..:.:.....|.|..|..:|.:|.|:.:|
  Rat   219 HFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADE 283

  Fly   268 VIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLI 332
            |:.:||||.|||||..|..||:..|..|.:.|.|||...|.....|..::|...|.:||||:.|:
  Rat   284 VLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLV 348

  Fly   333 LYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLID 397
            |         ||.||||..::.:...:|::|..|...|..||.|:....:|:.|...|||..:||
  Rat   349 L---------DEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVID 404

  Fly   398 PLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLL 462
            .:|..|..|: .:||.:||.:|.|.||:|.||.:|..|::|::.|:|.||||.||.||||.:||:
  Rat   405 CMSGDGYKLD-RIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLI 468

  Fly   463 QRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAK 527
            ||||||..|.|.|||.|:|..||:|||..|.:|.||||||..:|.||||.|:.:||.:::..|||
  Rat   469 QRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAK 533

  Fly   528 AANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQ 592
            .|||::||:||.:.:||.:.|.|.|:||||:||:|||||||:.|||||||.||||||..||..||
  Rat   534 DANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEARVQ 598

  Fly   593 AALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSA 657
            .||:|...|.|.:.|:||||.:|.|..|:..|:|.|||:||||||::.:|.|..:||:.|..|:|
  Rat   599 EALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTLQSQGDNA 663

  Fly   658 EELLNEL-EEVAEIKERKMSYEVEPYQLGTRNSIVSLEKN-------------AEFQMKNLNGLA 708
            .:..:.: ::..|....:.::....|:...|.||....|:             |:.:....:...
  Rat   664 HKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKD 728

  Fly   709 NITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLA 773
            |..:.:|::...|.         |||.:..|||.::::|::.|.:.|...|::|::.::|.|:.:
  Rat   729 NDVLVEEVEPAPVR---------RILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFS 784

  Fly   774 KPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDR 838
            ....|:...:..||.:..:::|..:....::|.:.|..:|..||.|:|...|:.::.|::||||.
  Rat   785 LLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDD 849

  Fly   839 KENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVAS 903
            ..|:.|.|:.||:.||:.||||.|..:..::.:|||.|.::.|||.:||:|:||.....||:..|
  Rat   850 LRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALS 914

  Fly   904 IVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLK 968
            ...:.:.....|.::|:.||:..:|.:|.::.||||||:..|...||.::.|::......:.:..
  Rat   915 GAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKAN 979

  Fly   969 WRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAA 1033
            ..||..:..:.:.|...:....|||::.|...:.|..:.::.:::......:.::.::||::..|
  Rat   980 IYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKA 1044

  Fly  1034 LLSANRMYEIIDRKPQIQ-SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNF 1097
            .:||.|.::::||||.|. ..|:.|...|..|.          :.:....|:|||||.|:||...
  Rat  1045 KISAARFFQLLDRKPPINVYSEAGEKWDNFQGK----------IDFIDCKFTYPSRPDIQVLNGL 1099

  Fly  1098 NLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHD---MDLKTLRRRLGIVS 1159
            ::.:|.|||:|.||:||.||||.:|||.|:||||:|.::||    .||   ::::.||..:||||
  Rat  1100 SVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMID----GHDSKKVNIQFLRSNIGIVS 1160

  Fly  1160 QEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQ 1224
            |||.||:.||.|||.|||.::::.:::.|.|||.|..|:|:||||.:|:|.:|.:|:|||.|:||
  Rat  1161 QEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQ 1225

  Fly  1225 RIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQ 1289
            |||||||:||:||||||||||||||.:||:.||.|||.|..||||||||||||||||:::|.|:.
  Rat  1226 RIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVS 1290

  Fly  1290 AGKIVEQGSHSQLLAKNGIYSKL 1312
            .|.::|:|:|.:|:|:.|.|.||
  Rat  1291 QGVVIEKGTHEKLMAQKGAYYKL 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	481/1260 (38%)
		ABC_membrane	<147..333	CDD:279056	67/193 (35%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	131/234 (56%)
		ABC_membrane	749..1019	CDD:279056	74/269 (28%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	134/240 (56%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	470/1197 (39%)
Abcb11	NP_113948.1	Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	651..674		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2784
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730