DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB9

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001328203.1	Gene:	ABCB9 / 827530	AraportID:	AT4G18050	Length:	1246	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	477/1332 - (35%)
Similarity:	726/1332 - (54%)	Gaps:	132/1332 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87
            :|..|..:.....||:.:||.:....|.:::..|.:||....|..|...:::.:|:..|
plant    13 EKSSKKNDGGNQKVSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLIFGQLINAF------ 71

  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVY-YVDAFNRLA 151
             ||:..                  :..::|:.|.:|.|           ::..|| .|.||.:::
plant    72 -GTTDP------------------DHMVREVWKVAVKF-----------IYLAVYSCVVAFLQVS 106

  Fly   152 L------KLTVRMRREFFKATLRQEIGWHDMAKDQNFAV-RITDNMEKIRSGIAENLGHYVEIMC 209
            .      :.:..:|..:.|..|||:||:.|...:....: |::.:...|:..:.|.:|.:.:::|
plant   107 CWMVTGERQSATIRGLYLKTILRQDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVGKFTQLLC 171

  Fly   210 DVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRT 274
            ..:....::|..|..||..:...|||.::..:|::....|:.|:.|.:|..|.:|||:.:|||||
plant   172 TFLGGFAIAFYKGPLLAGVLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQTVGAIRT 236

  Fly   275 VVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPS 339
            ||||.||:..:.:|:|.|:.|.|....:|..||.....|.|::|.:...:.||||.||:
plant   237 VVAFTGEKQATEKYESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLIM------ 295

  Fly   340 IPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGK 404
                |:.|....|:.||..::.....:.:|||.|..||..|.:|..:.:.|.|:..||....:|.
plant   296 ----EKGYNGGQVINVIFAVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDMSGS 356

  Fly   405 ILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPV 469
            :|. .::|.:|.:||:||||||.||.:..|.::.|..|:||||||.||.||||.|.|::|||||.
plant   357 VLE-DIRGDIELKDVYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFYDPE 420

  Fly   470 FGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDF 534
            .||||:|..|::|..:||:||.|.:|.||||||..:|.|||.:||.:||.:|:..|.:.|||..|
plant   421 SGQVLIDNIDLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANAAKF 485

  Fly   535 IIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKAC 599
            |..|.:|.||.:.|.|.|:||||:||:|||||:::.||||||||||||||..||::||.||....
plant   486 IDKLPQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALVNLM 550

  Fly   600 KGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMK-LEGFYHKMVTVHSYDDSAEELLNE 663
            ..|||:||:|||:.||.|..|..:..||.||:|||:|::: .||.|.::|.:..         ..
plant   551 SNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRLQE---------GS 606

  Fly   664 LEEVAEIKERKMSYEVE---PYQLG-------TRNS-----IVSLEKNAEFQMKNLNGLANITMN 713
            .||..|.:..:.|.:||   ..:|.       :|||     ..||..|..|...|:|      ..
plant   607 KEEATESERPETSLDVERSGSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVN------QT 665

  Fly   714 QEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDE 778
            .|::|......:...:..|:....:||...|::|:|.|.::|...|:|.::|:.......:|.
plant   666 DEMEDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINMFYEPA-- 728

  Fly   779 EVLEQSASM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENS 842
            ::|::.:.. |:|.:.:|:...|:..:|.:||.:||..|..|:||..|..:::||:.|||
plant   729 KILKKDSHFWALIYIALGLTNFVMIPVQNYFFGIAGGKLIKRIRSMCFDKVVHQEISWFD----- 788

  Fly   843 IGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFE 907
                      |.|:.:..:|..|:.|:|........:.|||..:|.||||.|:.|||:|.....:
plant   789 ----------DTANSRSLVGDALALIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQGYAQ 843

  Fly   908 ARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGL 972
            .:|....:...|.:.||.|::|.:.::.|||||....||:::.:|.::.:..:...: ||   ||
plant   844 TKFLTGFSADAKAMYEEASQVANDAVSSIRTVASFCAEEKVMDLYQQKCDGPKKNGV-RL---GL 904

  Fly   973 VNSLGKSLMFFGY----AVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILA----QSLAFTPA 1029
            ::..|....||..    .|....|..:...||..|..:.|:    .:.|.|:|    |:.|..|.
plant   905 LSGAGFGFSFFFLYCINCVCFVSGAGLIQIGKATFGEVFKV----FFALTIMAIGVSQTSAMAPD 965

  Fly  1030 FNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVL 1094
            .|.|..||..:::|:|..|:|.|       .:..||..:.  |...:.:|.::|.||.||.:::.
plant   966 SNKAKDSAASIFDILDSTPKIDS-------SSDEGTTLQN--VNGDIEFRHVSFRYPMRPDVQIF 1021

  Fly  1095 QNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVS 1159
            ::..|.|..|:||||||.|||||||.:.::.|:|:||.|||||||..| ....|..||:::|:||
plant  1022 RDLCLTIPSGKTVALVGESGSGKSTVISMIERFYNPDSGKILIDQVEI-QTFKLSWLRQQMGLVS 1085

  Fly  1160 QEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQ 1224
            |||.||.::|..||.||.|..... ::||.|||.||||.||.|||..|||.:|.:|.||||||||
plant  1086 QEPILFNETIRSNIAYGKTGGATE-EEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGGQKQ 1149

  Fly  1225 RIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQ 1289
            |||||||::::||||||||||||||.:||||||.|||.....||.:|:||||:||:||:||.|::
plant  1150 RIAIARAILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLTTIKNADVIAVVK 1214

  Fly  1290 AGKIVEQGSHSQLL-AKNGIYSKLYRCQTKAS 1320
            .|.|.|:|.|..|: ...|.|:.|......|:
plant  1215 NGVIAEKGRHETLMKISGGAYASLVTLHMSAN 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	462/1263 (37%)
		ABC_membrane	<147..333	CDD:279056	57/192 (30%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	128/235 (54%)
		ABC_membrane	749..1019	CDD:279056	74/274 (27%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	131/240 (55%)
ABCB9	NP_001328203.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790