DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB21

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001327192.1	Gene:	ABCB21 / 825388	AraportID:	AT3G62150	Length:	1296	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	485/1332 - (36%)
Similarity:	759/1332 - (56%)	Gaps:	100/1332 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSEL 77
            :|..|.....:|.|:.:::....|.:.:||.:...:|.::::.|.:.|....|.|||..:::.::
plant    40 SDLKEEKKKTEKNKQEEDEKTKTVPFHKLFAFADSFDIILMILGTIGAVGNGLGFPIMTILFGDV 104

  Fly    78 VAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVY 142
            :.:|     ||..:|..:.                   .::.|.::.| :.:.|.||:   :.:.
plant   105 IDVF-----GQNQNSSDVS-------------------DKIAKVALKF-VYLGLGTLV---AALL 141

  Fly   143 YVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAV-RITDNMEKIRSGIAENLGHYVE 206
            .|..:.....:...|:|..:.:..|||:|.:.|:..:....| |::.:...|:..:.|.:|..::
plant   142 QVSGWMISGERQAGRIRSLYLQTILRQDIAFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKAIQ 206

  Fly   207 IMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGA 271
            ::...|...|::|..||.|.|.:|..|||.::..:|:|....|:..:.|:||.:|:.|||:.:|:
plant   207 LVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMSGAALAIVISKMASRGQTSYAKAAVVVEQTVGS 271

  Fly   272 IRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYR 336
            ||||.:|.||:.....|:..|..|.:||.::||.:||....:..::|.|.|.:.|||..:||
plant   272 IRTVASFTGEKQAISNYNKHLVSAYRAGVFEGASTGLGLGTLNIVIFCTYALAVWYGGKMIL--- 333

  Fly   337 DPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSK 401
                   |:.||...|:|:|..::..:..:.:.||.|..||..:.:|..:.:.|.|...||....
plant   334 -------EKGYTGGQVLIIIFAVLTGSMSLGQASPCLSAFAAGQAAAYKMFEAIKRKPEIDASDT 391

  Fly   402 AGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFY 466
            .||:|: .::|.:|..:|.|.||||.:..:.||.::.:..|.||||||.||.||||.:.|::|||
plant   392 TGKVLD-DIRGDIELNNVNFSYPARPEEQIFRGFSLSISSGSTVALVGQSGSGKSTVVSLIERFY 455

  Fly   467 DPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANA 531
            ||..|:|.:||.:::::.:||:||.|.:|.||||||..||.|||.:||..||.:|:..|.:.|||
plant   456 DPQSGEVRIDGINLKEFQLKWIRSKIGLVSQEPVLFTSSIKENIAYGKENATVEEIRKATELANA 520

  Fly   532 HDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALD 596
            ..||..|.:|.||.:.|.|.||||||:||||:|||:::.|:||||||||||||..||::||.|||
plant   521 SKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERIVQEALD 585

  Fly   597 KACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMK-LEGFYHKMVTVH----SYDDS 656
            :....|||:||:||||.:|:|..|..|..||.||:|:|.||:: .||.|.:::.:.    ..:||
plant   586 RIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQEDTKQTEDS 650

  Fly   657 AEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRV 721
            .:|....:|.:.....||.|..   ..|..|:|..|:          ....|.|..|.|    .:
plant   651 TDEQKLSMESMKRSSLRKSSLS---RSLSKRSSSFSM----------FGFPAGIDTNNE----AI 698

  Fly   722 PSANF-IST--------FFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTD 777
            |..:. :||        |||:....:||...||:|:|.|.|.||.:|:|.::::.:..:..|| .
plant   699 PEKDIKVSTPIKEKKVSFFRVAALNKPEIPMLILGSIAAVLNGVILPIFGILISSVIKAFFKP-P 762

  Fly   778 EEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENS 842
            |::...:...|||.:::|:|:.||...||.||::||..|..|:||..|..::..|:||||..|||
plant   763 EQLKSDTRFWAIIFMLLGVASMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETENS 827

  Fly   843 IGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFE 907
            .||:.||||.|||:|:|.:|..|:..:|...:....:.|||..||:||.|.|:..|.:..:....
plant   828 SGAIGARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIGLNGYIY 892

  Fly   908 ARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGL 972
            .:|....:...|.:.||.|::|.:.:..|||||....||:::|:|.|:.|......:.    :|:
plant   893 MKFMVGFSADAKRMYEEASQVANDAVGSIRTVASFCAEEKVMKMYKKKCEGPMRTGIR----QGI 953

  Fly   973 VNSLGKSLMFF----GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAA 1033
            |:.:|..:.||    .||.:...|..:..|||..|:::.::...:......::||.:.:|..:.|
plant   954 VSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVAISQSSSLSPDSSKA 1018

  Fly  1034 LLSANRMYEIIDRKPQIQ-SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNF 1097
            ..:|..::.:|||:.:|. |.||..:..|          |:..:..|.::|.|||||.:::.|:.
plant  1019 SNAAASIFAVIDRESKIDPSDESGRVLDN----------VKGDIELRHISFKYPSRPDVQIFQDL 1073

  Fly  1098 NLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEP 1162
            .|.|..|:|:||||.|||||||.:.||.|:||||.|:|.:|...| ..:.||.||::.|:|||||
plant  1074 CLSIRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEI-KTLQLKWLRQQTGLVSQEP 1137

  Fly  1163 SLFEKSIADNIGY---GDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQ 1224
            .||.::|..||.|   ||.:.    .:|:.||:::|||.||..|...|||::|.:|.||||||||
plant  1138 VLFNETIRANIAYGKGGDATE----TEIVSAAELSNAHGFISGLQQGYDTMVGERGVQLSGGQKQ 1198

  Fly  1225 RIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQ 1289
            |:|||||:|::||:|||||||||||.:||||||.|||.....||.:|:|||||||:||:||.|::
plant  1199 RVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLSTIKNADVIAVVK 1263

  Fly  1290 AGKIVEQGSHSQLL-AKNGIYSKLYRCQTKAS 1320
            .|.|||:|.|..|: .|:|:|:.|.:....||
plant  1264 NGVIVEKGKHETLINIKDGVYASLVQLHLSAS 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	468/1253 (37%)
		ABC_membrane	<147..333	CDD:279056	56/186 (30%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	123/235 (52%)
		ABC_membrane	749..1019	CDD:279056	89/273 (33%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	129/243 (53%)
ABCB21	NP_001327192.1	PTZ00265	16..1290	CDD:240339	483/1325 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790